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A5FUK7 (MRAY_ACICJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:Acry_0060
OrganismAcidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]
Taxonomic identifier349163 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_0000332523

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane75 – 9521Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane136 – 15621Helical; Potential
Transmembrane170 – 19021Helical; Potential
Transmembrane201 – 22121Helical; Potential
Transmembrane247 – 26721Helical; Potential
Transmembrane290 – 31021Helical; Potential
Transmembrane339 – 35921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A5FUK7 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 1201B95D4AA18706

FASTA36239,023
        10         20         30         40         50         60 
MLYALLLPHV AAFHAFNLIR YITFRAGGAC LTALVVSFLL GPRLIRWLKS LQKQGQPIRA 

        70         80         90        100        110        120 
DGPERHLIEK KGTPTMGGFL ILIALTVSTL LWADLRNGYV WAVLMITIGY GALGFADDFL 

       130        140        150        160        170        180 
KLTKRNTKGV PGRIKLVVQA VLGLGAAVWI TQLMPGSIAD SLAVPVFKHL MIPFGPLFPL 

       190        200        210        220        230        240 
VAMFVMMGAS NAVNLTDGLD GLAIVPTIIA AGVFTLIAYL VGNRIFSHYL EINFVPGTGE 

       250        260        270        280        290        300 
LAVFCSALIG AGMGFLWFNA PPAAVFMGDT GSLALGGALG SVAVATKNEI VLAITGGLFV 

       310        320        330        340        350        360 
VETVSVIVQV FWYKRTGRRV FLMAPLHHHF EKKGWAEPTV VIRFWIVAMI LALLGLATLK 


IR

« Hide

References

[1]"Complete sequence of chromosome of Acidiphilium cryptum JF-5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000697 Genomic DNA. Translation: ABQ29289.1.
RefSeqYP_001233208.1. NC_009484.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA5FUK7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5160779.
GenomeReviewsGene locus Acry_0060 in contig CP000697_GR.
KEGGacr:Acry_0060.
PATRIC20645062. VBIAciCry6074_0538.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycACRY349163:ACRY_0060-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. False negative.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ACICJ
AccessionPrimary (citable) accession number: A5FUK7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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