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A5FUH8 (AROA_ACICJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS
Gene names
Name:aroA
Ordered Locus Names:Acry_0031
OrganismAcidiphilium cryptum (strain JF-5) [Complete proteome] [HAMAP]
Taxonomic identifier349163 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Acidiphilium

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4454453-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
PRO_1000058592

Sequences

Sequence LengthMass (Da)Tools
A5FUH8 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 16104C7D825F7565

FASTA44545,982
        10         20         30         40         50         60 
MEHAATLPQT SRRPATPLTG TITVPGDKSI SHRALMFAGL AVGETRISGL LEGEDVLRTA 

        70         80         90        100        110        120 
AAMRALGATV ERTGPGAWRA SGPGIGGLQS PDDVLDMGNS GTAARLLCGI LASHDIFAVM 

       130        140        150        160        170        180 
TGDASLRRRP MRRVIDPLGA TGAVFAAREG GRLPLSVRGA AEAMPLSYRL PVASAQVKSA 

       190        200        210        220        230        240 
LLLAGLNARG ITEIEEPEPT RDHSENMLRH FGAEVEVAAH GTGKLIRLRG QPELRGADVV 

       250        260        270        280        290        300 
VPGDPSSAAF PIVAALIVPG SRVTIGGVGL NPLRTGLFLT LREMGAAIEI VNAREAGGEP 

       310        320        330        340        350        360 
VGDLIVTASD LRAVDVPAER APSMIDEYPI LAVACAMARG SSRLRGLAEL RVKESDRLAA 

       370        380        390        400        410        420 
TLAMITANGV KAQVDGDDLI IEGGGARGGA TVATHMDHRL AMSALVMGLA TETPVTIDDA 

       430        440 
RFIDTSFPGF LPLMRGIGAA IEAAA

« Hide

References

[1]"Complete sequence of chromosome of Acidiphilium cryptum JF-5."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Kim E., Magnuson T., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JF-5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000697 Genomic DNA. Translation: ABQ29260.1.
RefSeqYP_001233179.1. NC_009484.1.

3D structure databases

ProteinModelPortalA5FUH8.
SMRA5FUH8. Positions 12-443.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5FUH8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5161081.
GenomeReviewsGene locus Acry_0031 in contig CP000697_GR.
KEGGacr:Acry_0031.
PATRIC20644998. VBIAciCry6074_0508.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0128.
HOGENOMHBG646626.
OMALECANIS.
ProtClustDBPRK02427.

Enzyme and pathway databases

BioCycACRY349163:ACRY_0031-MONOMER.

Family and domain databases

HAMAPMF_00210. EPSP_synth.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00800.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA_ACICJ
AccessionPrimary (citable) accession number: A5FUH8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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