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A5FS02

- NAK_DEHMB

UniProt

A5FS02 - NAK_DEHMB

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Protein
NAD kinase
Gene
nadK, DehaBAV1_0435
Organism
Dehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Proton acceptor By similarity
Binding sitei66 – 661NAD By similarity
Binding sitei147 – 1471NAD By similarity
Binding sitei164 – 1641NAD By similarity
Binding sitei166 – 1661NAD By similarity
Binding sitei201 – 2011NAD; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 622NAD By similarity
Nucleotide bindingi136 – 1372NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciDSP216389:GH6D-443-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:DehaBAV1_0435
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1)
Taxonomic identifieri216389 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
ProteomesiUP000002607: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284NAD kinaseUniRule annotation
PRO_1000079488Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi216389.DehaBAV1_0435.

Structurei

3D structure databases

ProteinModelPortaliA5FS02.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiHPSIPGW.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A5FS02-1 [UniParc]FASTAAdd to Basket

« Hide

MYKKIGIIYH PLNPAACDLA IKLAAKLDSL GIENWSDSAW QADKLTPKMQ    50
NTQLILTTGG DGTILRTAHA ILPLEIPILS VNLGKVGFMT ELSPEDAISG 100
LEKVLAGDGW IDERSLLEAE YLPHDSAQSR QFFVMNDAVV ARGQVARVIC 150
VSVDINSQPF TTYKADGAIV STATGSTGYS YAAGGPVLQP NSADIILTPI 200
LPHLGRGYSL VLPSDSIVDL KVNTWHEATL SIDGFINMQV SSGDTLRLRQ 250
SSKKIQFIRL RPENYFYKGL DTKLKGNNES VYDR 284
Length:284
Mass (Da):30,966
Last modified:June 12, 2007 - v1
Checksum:iEF5AC03F57C9C7AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000688 Genomic DNA. Translation: ABQ17020.1.
RefSeqiYP_001213898.1. NC_009455.1.

Genome annotation databases

EnsemblBacteriaiABQ17020; ABQ17020; DehaBAV1_0435.
GeneIDi5131830.
KEGGideb:DehaBAV1_0435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000688 Genomic DNA. Translation: ABQ17020.1 .
RefSeqi YP_001213898.1. NC_009455.1.

3D structure databases

ProteinModelPortali A5FS02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 216389.DehaBAV1_0435.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ17020 ; ABQ17020 ; DehaBAV1_0435 .
GeneIDi 5131830.
KEGGi deb:DehaBAV1_0435.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi HPSIPGW.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci DSP216389:GH6D-443-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1.

Entry informationi

Entry nameiNAK_DEHMB
AccessioniPrimary (citable) accession number: A5FS02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: July 9, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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