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A5FRZ7 (AROB_DEHSB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:DehaBAV1_0444
OrganismDehalococcoides sp. (strain BAV1) [Complete proteome] [HAMAP]
Taxonomic identifier216389 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3593593-dehydroquinate synthase HAMAP MF_00110
PRO_1000094502

Sequences

Sequence LengthMass (Da)Tools
A5FRZ7 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 2BE3E9E71097FB14

FASTA35939,007
        10         20         30         40         50         60 
MKSIGLNLSG REYKILIGSD LLSETATLLR EAIPCDRVVV ITNIDINRIY GKKLKKHLES 

        70         80         90        100        110        120 
KGIESLFLEL PEGEIHKTLD MAAHIYPQLI NHFAERNTPI LALGGGVIGD LSGFVAATYQ 

       130        140        150        160        170        180 
RGVPLIHLPT SLLSQVDSSI GGKVAVNHGG VKNIVGSFYQ PRLVIADTGC LKTLPEKEFA 

       190        200        210        220        230        240 
CGMAEIIKSA AIGSSELFRM LETNTQAVKD RSPEVMEDII SQTAAIKAGI VCQDETDRGI 

       250        260        270        280        290        300 
RNILNFGHTL GHALESTSSF SQSHGAAVAI GMCFAARLSV RLGLCENETA LRLEKLIADF 

       310        320        330        340        350 
GLPTNPKDID PDKIIEAMHH DKKVSDGRIR FILLKRPGEA LIAENILKPD VLSVLEEMK

« Hide

References

[1]"Complete sequence of Dehalococcoides sp. BAV1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ritalahti K.M., Loeffler F., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BAV1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000688 Genomic DNA. Translation: ABQ17029.1.
RefSeqYP_001213907.1. NC_009455.1.

3D structure databases

ProteinModelPortalA5FRZ7.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5FRZ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5131196.
GenomeReviewsGene locus DehaBAV1_0444 in contig CP000688_GR.
KEGGdeb:DehaBAV1_0444.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycDSP216389:DEHABAV1_0444-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_DEHSB
AccessionPrimary (citable) accession number: A5FRZ7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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