ID   AROE_DEHSB              Reviewed;         286 AA.
AC   A5FRZ5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=DehaBAV1_0442;
OS   Dehalococcoides sp. (strain BAV1).
OC   Bacteria; Chloroflexi; Dehalococcoidetes; Dehalococcoides.
OX   NCBI_TaxID=216389;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Lowry S.,
RA   Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Kim E., Ritalahti K.M., Loeffler F., Richardson P.;
RT   "Complete sequence of Dehalococcoides sp. BAV1.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; CP000688; ABQ17027.1; -; Genomic_DNA.
DR   RefSeq; YP_001213905.1; -.
DR   GeneID; 5131197; -.
DR   GenomeReviews; CP000688_GR; DehaBAV1_0442.
DR   KEGG; deb:DehaBAV1_0442; -.
DR   OMA; A5FRZ5; ATAIQVQ.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    286       Shikimate dehydrogenase.
FT                                /FTId=PRO_1000078119.
FT   NP_BIND     130    134       NADP (By similarity).
FT   ACT_SITE     70     70       Proton acceptor (Potential).
SQ   SEQUENCE   286 AA;  31321 MW;  E42021D763509617 CRC64;
     MQTIPDALFG IIGYPVSHSV SPAMQNAAFK HCKLNYLYLT IAAKPEDLQN VIASMRPLNI
     RGLNVTIPHK IEVIKYIDTL DPAAKKIGAV NTIVNENGQM KGYNTDFGGF VRLLEHNRIA
     PAKHRFALLG AGGSAHAISL AICTLGGHLT VLARQEEKAK DLAAKMCLRF KGKAQGLELN
     EANLEETLAE SDIIVNCTPI GMGNLAGQSL ISPRLLRPDL TVIDAIYNPC KTRLLEDAEK
     KGAKIINGLE MLVWQGAMSF EIWTSQKAPF RVMMKEAEMA LDENEK
//