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Protein

Endonuclease V

Gene

nfi

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45MagnesiumUniRule annotation1
Metal bindingi113MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciDMCC216389:G1G8W-571-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease VUniRule annotation (EC:3.1.21.7UniRule annotation)
Alternative name(s):
Deoxyinosine 3'endonucleaseUniRule annotation
Deoxyribonuclease VUniRule annotation
Short name:
DNase VUniRule annotation
Gene namesi
Name:nfiUniRule annotation
Ordered Locus Names:DehaBAV1_0543
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1)
Taxonomic identifieri216389 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002129711 – 223Endonuclease VAdd BLAST223

Proteomic databases

PRIDEiA5FRP8

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei83Interaction with target DNAUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliA5FRP8
SMRiA5FRP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endonuclease V family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229135
KOiK05982
OMAiCKYRVPE

Family and domain databases

CDDicd06559 Endonuclease_V, 1 hit
HAMAPiMF_00801 Endonuclease_5, 1 hit
InterProiView protein in InterPro
IPR007581 Endonuclease-V
PANTHERiPTHR28511 PTHR28511, 1 hit
PfamiView protein in Pfam
PF04493 Endonuclease_5, 1 hit

Sequencei

Sequence statusi: Complete.

A5FRP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVKIKKLHN WDMTPTEAIL LQRELAQKVS ACGTLSSISL VAGADVWHSR
60 70 80 90 100
TSGMGRAAVV VLSYPDMNLV EVSRSEGDCH IPYIPGLLSF REMPLLLSAF
110 120 130 140 150
EGLESMPDLI LMDGQGLAHP RRLGIASHLG LFLNKPVIGC AKSRLVGEYT
160 170 180 190 200
PLADEAGSYS DLYHNSQLVG RVLRTRRGVN PLFISVGHKI CLEEACSRVA
210 220
DCCRGYRLPE PLRHAHLAAA ELI
Length:223
Mass (Da):24,396
Last modified:June 12, 2007 - v1
Checksum:i0F95EB45398F96C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000688 Genomic DNA Translation: ABQ17128.1
RefSeqiWP_011928919.1, NC_009455.1

Genome annotation databases

EnsemblBacteriaiABQ17128; ABQ17128; DehaBAV1_0543
KEGGideb:DehaBAV1_0543
PATRICifig|216389.18.peg.588

Similar proteinsi

Entry informationi

Entry nameiNFI_DEHMB
AccessioniPrimary (citable) accession number: A5FRP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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