Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endonuclease V

Gene

nfi

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451MagnesiumUniRule annotation
Metal bindingi113 – 1131MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciDSP216389:GH6D-551-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease VUniRule annotation (EC:3.1.21.7UniRule annotation)
Alternative name(s):
Deoxyinosine 3'endonucleaseUniRule annotation
Deoxyribonuclease VUniRule annotation
Short name:
DNase VUniRule annotation
Gene namesi
Name:nfiUniRule annotation
Ordered Locus Names:DehaBAV1_0543
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1)
Taxonomic identifieri216389 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Endonuclease VPRO_1000212971Add
BLAST

Interactioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei83 – 831Interaction with target DNAUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA5FRP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endonuclease V family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229135.
KOiK05982.
OMAiHAHRLVN.

Family and domain databases

CDDicd06559. Endonuclease_V. 1 hit.
HAMAPiMF_00801. Endonuclease_5. 1 hit.
InterProiIPR007581. Endonuclease-V.
[Graphical view]
PfamiPF04493. Endonuclease_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5FRP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVKIKKLHN WDMTPTEAIL LQRELAQKVS ACGTLSSISL VAGADVWHSR
60 70 80 90 100
TSGMGRAAVV VLSYPDMNLV EVSRSEGDCH IPYIPGLLSF REMPLLLSAF
110 120 130 140 150
EGLESMPDLI LMDGQGLAHP RRLGIASHLG LFLNKPVIGC AKSRLVGEYT
160 170 180 190 200
PLADEAGSYS DLYHNSQLVG RVLRTRRGVN PLFISVGHKI CLEEACSRVA
210 220
DCCRGYRLPE PLRHAHLAAA ELI
Length:223
Mass (Da):24,396
Last modified:June 12, 2007 - v1
Checksum:i0F95EB45398F96C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000688 Genomic DNA. Translation: ABQ17128.1.
RefSeqiWP_011928919.1. NC_009455.1.

Genome annotation databases

EnsemblBacteriaiABQ17128; ABQ17128; DehaBAV1_0543.
KEGGideb:DehaBAV1_0543.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000688 Genomic DNA. Translation: ABQ17128.1.
RefSeqiWP_011928919.1. NC_009455.1.

3D structure databases

ProteinModelPortaliA5FRP8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ17128; ABQ17128; DehaBAV1_0543.
KEGGideb:DehaBAV1_0543.

Phylogenomic databases

HOGENOMiHOG000229135.
KOiK05982.
OMAiHAHRLVN.

Enzyme and pathway databases

BioCyciDSP216389:GH6D-551-MONOMER.

Family and domain databases

CDDicd06559. Endonuclease_V. 1 hit.
HAMAPiMF_00801. Endonuclease_5. 1 hit.
InterProiIPR007581. Endonuclease-V.
[Graphical view]
PfamiPF04493. Endonuclease_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNFI_DEHMB
AccessioniPrimary (citable) accession number: A5FRP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 12, 2007
Last modified: September 7, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.