A5FRF4 (A5FRF4_DEHSB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543
Ordered Locus Names:	DehaBAV1_0640

Organism

Dehalococcoides sp. (strain BAV1) [Complete proteome] [HAMAP]

Taxonomic identifier

216389 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	605 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS020628
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS020628
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS020628
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS020628 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS020628 EMBL ABQ17225.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	92 – 99	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	A5FRF4 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 94592473C1B0807D	FASTA	605	65,490
	10 20 30 40 50 60 MKVLRGNILA VNDREFHLKE LDPVLMKDWE IAEKAEDFLK PVKVLAMELG LTEDEIIPHG 70 80 90 100 110 120 KYIAKVDFAG VLARLKDRPN GKYIDVTAIT PTPLGEGKST TTMGLVQGLG KLGKKVTGAI 130 140 150 160 170 180 RQPSSGPTFN IKGSAAGGGL SQCLPLSPFS LGLTGDIDAV TNSHNLAMVA LQARLQHEAN 190 200 210 220 230 240 NTDEFLSSRH LTRLDIDPSR VEMKWAMDFC AQSLREIIMG IGSKTDGYRM PSGFGISVSS 250 260 270 280 290 300 EVMAILSVFT SLSDLRERMG KIIVAYRKND EPVTTADLEV DGAMTALLLR AVNPNLLQTI 310 320 330 340 350 360 EGQPVFVHAG PFANIAIGQS SIVADRLALK LADYHVTESG FGADIGFEKF WNIKCRLSGL 370 380 390 400 410 420 KPDCAVIVVT ARALKMHGGG PKVTPGTPLD PAYTTPNTKL VEKGCQNMLA HIQTVKTAGI 430 440 450 460 470 480 NPVVCINHFA ADTHEEIDII RRTAEQAEAR VAVSHHWAKG GDGATELAEA VTDACNEPNN 490 500 510 520 530 540 FHFLYPENMP LKKRIETIAR KVYGANGVSY TPIAMEKLAR IESMGDTQFM PTCMVKTHLS 550 560 570 580 590 600 LSHDPALKGR PSGFTLPIRD ILTYMGAGLV VPVAGDIKLM PGTSSDPNFR RIDIDTQTGK VKGLF

References

[1]

"Complete sequence of Dehalococcoides sp. BAV1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ritalahti K.M., Loeffler F., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BAV1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000688 Genomic DNA. Translation: ABQ17225.1.
RefSeq	YP_001214103.1. NC_009455.1.
3D structure databases
ProteinModelPortal	A5FRF4.
ModBase	Search...
Protein-protein interaction databases
STRING	A5FRF4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5131863.
GenomeReviews	Gene locus DehaBAV1_0640 in contig CP000688_GR.
KEGG	deb:DehaBAV1_0640.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HBG677721.
OMA	EIMAVLC.
ProtClustDB	PRK13507.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5FRF4_DEHSB

Accession

Primary (citable) accession number: A5FRF4

Entry history

Integrated into UniProtKB/TrEMBL:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	November 16, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)