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A5FR69

- PANC_DEHMB

UniProt

A5FR69 - PANC_DEHMB

Protein

Pantothenate synthetase

Gene

panC

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei34 – 341Proton donorUniRule annotation
    Binding sitei58 – 581Beta-alanineUniRule annotation
    Binding sitei58 – 581PantoateUniRule annotation
    Binding sitei150 – 1501PantoateUniRule annotation
    Binding sitei173 – 1731ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi27 – 348ATPUniRule annotation
    Nucleotide bindingi144 – 1474ATPUniRule annotation
    Nucleotide bindingi181 – 1844ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDSP216389:GH6D-746-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:DehaBAV1_0728
    OrganismiDehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1)
    Taxonomic identifieri216389 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides
    ProteomesiUP000002607: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 277277Pantothenate synthetasePRO_1000076853Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi216389.DehaBAV1_0728.

    Structurei

    3D structure databases

    ProteinModelPortaliA5FR69.
    SMRiA5FR69. Positions 1-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OMAiEIDYVEV.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5FR69-1 [UniParc]FASTAAdd to Basket

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    MRIIRTVDEM KKLHREICGP VGLVPTMGYL HEGHLSLVRA SKKQDINTVA    50
    SIFVNPTQFG PHEDFKKYPR DEKRDMAMLE NAGVDYVFAP SVEDMYPAGF 100
    DSWVEPGILQ QCLEGAIRPG HFRGVCTVVA KLFTIIRPDR AYFGQKDYQQ 150
    YLIIKRMASD LNLDVSVEML PIIRENDGLA LSSRNTYLSP AERQAALVLY 200
    RSLLTARSLF DEKEHRAEVI RKKMTDVIQH ESMAEIDYVS LSHQDTLCES 250
    DEVSAKTIAL VAARFGKTRL IDNMFLA 277
    Length:277
    Mass (Da):31,456
    Last modified:June 12, 2007 - v1
    Checksum:i25D411BF57C6880F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000688 Genomic DNA. Translation: ABQ17312.1.
    RefSeqiYP_001214190.1. NC_009455.1.

    Genome annotation databases

    EnsemblBacteriaiABQ17312; ABQ17312; DehaBAV1_0728.
    GeneIDi5131465.
    KEGGideb:DehaBAV1_0728.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000688 Genomic DNA. Translation: ABQ17312.1 .
    RefSeqi YP_001214190.1. NC_009455.1.

    3D structure databases

    ProteinModelPortali A5FR69.
    SMRi A5FR69. Positions 1-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 216389.DehaBAV1_0728.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ17312 ; ABQ17312 ; DehaBAV1_0728 .
    GeneIDi 5131465.
    KEGGi deb:DehaBAV1_0728.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OMAi EIDYVEV.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci DSP216389:GH6D-746-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1.

    Entry informationi

    Entry nameiPANC_DEHMB
    AccessioniPrimary (citable) accession number: A5FR69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3