A5FQT3 (DAPB_DEHSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	DehaBAV1_0862

Organism

Dehalococcoides sp. (strain BAV1) [Complete proteome] [HAMAP]

Taxonomic identifier

216389 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_1000075675

Sequences

	Sequence		Length	Mass (Da)
	A5FQT3 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 0A92D62638086317	FASTA	263	28,076
	10 20 30 40 50 60 MTPIKVVVHG ASGKMGQEVL KTLCQENNLH PVGAVDIRAE NPAMALPDGS GSIPYSADLS 70 80 90 100 110 120 SILSQTKPDV MVDFTVAKAS MPAVRIAAAH KVNLVIGTTG FSPEEISEIE QLAKTNDIGI 130 140 150 160 170 180 ILAPNFALGA IIMVHLAQVA SRFLSSAEVI ELHHDKKLDS PSGTALVTVA SMLEARGEAF 190 200 210 220 230 240 NKPPKENLTD ARGQEHDGIR VHSVRLPGLL AHQEVIFGAA GQTLTIRHDA FSRECYMPGV 250 260 LLAIKEIVHT KGFVFGLDKL LKL

References

[1]

"Complete sequence of Dehalococcoides sp. BAV1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ritalahti K.M., Loeffler F., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BAV1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000688 Genomic DNA. Translation: ABQ17444.1.
RefSeq	YP_001214322.1. NC_009455.1.
3D structure databases
ProteinModelPortal	A5FQT3.
ModBase	Search...
Protein-protein interaction databases
STRING	A5FQT3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5131683.
GenomeReviews	Gene locus DehaBAV1_0862 in contig CP000688_GR.
KEGG	deb:DehaBAV1_0862.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0289.
HOGENOM	HBG594002.
OMA	DRASFMP.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	DSP216389:DEHABAV1_0862-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_DEHSB

Accession

Primary (citable) accession number: A5FQT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	June 12, 2007
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program