A5FQ84 (ARGB_DEHSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	DehaBAV1_1068

Organism

Dehalococcoides sp. (strain BAV1) [Complete proteome] [HAMAP]

Taxonomic identifier

216389 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000335625
Regions
	Region	46 – 47	2	Substrate binding By similarity
Sites
	Binding site	68	1	Substrate By similarity
	Binding site	166	1	Substrate By similarity
	Site	14	1	Transition state stabilizer By similarity
	Site	226	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5FQ84 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 376D9018D19FA094	FASTA	272	28,143
	10 20 30 40 50 60 MEMTQSSNHI VVIKLGGSVL DSKDTSLKDI ATLKQLGLKP VLIHGGASTV SAWSAKLGLE 70 80 90 100 110 120 TRLVNGERVT DDATLDVVAA ILAGLVNKEI VAALLDMGIK AAGISGVDSA TITGQIRATE 130 140 150 160 170 180 TGYLGDVVQV NTELITALLD ANITPVISPV SFHQTNRPSG SRRLLNINGD PVAGEIASAL 190 200 210 220 230 240 QAERLVFLTD VPAVKGKNGE ALGEISADHA AELLASGTAS GGMIPKLRSC LKATLAGSSA 250 260 270 CIIDGRKPHM LIRELTEGNC GTTVTGQHLR RS

References

[1]

"Complete sequence of Dehalococcoides sp. BAV1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ritalahti K.M., Loeffler F., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BAV1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000688 Genomic DNA. Translation: ABQ17648.1.
RefSeq	YP_001214526.1. NC_009455.1.
3D structure databases
ProteinModelPortal	A5FQ84.
ModBase	Search...
Protein-protein interaction databases
STRING	A5FQ84.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5131960.
GenomeReviews	Gene locus DehaBAV1_1068 in contig CP000688_GR.
KEGG	deb:DehaBAV1_1068.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	GGCLVDD.
ProtClustDB	CLSK837031.
Enzyme and pathway databases
BioCyc	DSP216389:DEHABAV1_1068-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR001057. Glu/AcGlu_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_DEHSB

Accession

Primary (citable) accession number: A5FQ84

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	June 12, 2007
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program