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A5FQ74 (ARLY_DEHSB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:DehaBAV1_1072
OrganismDehalococcoides sp. (strain BAV1) [Complete proteome] [HAMAP]
Taxonomic identifier216389 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoidales › Dehalococcoidaceae › Dehalococcoides ›

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP-Rule MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP-Rule MF_00006

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461Argininosuccinate lyase HAMAP-Rule MF_00006
PRO_1000073845

Sequences

Sequence LengthMass (Da)Tools
A5FQ74 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 33DA79ED5593A19D

FASTA46151,271
        10         20         30         40         50         60 
MSHIRSRFSK PADELVVRYT TSLPFDWRLY KEDIKCSTAH ARMLSKQGII STEDSQSIIN 

        70         80         90        100        110        120 
GLNAILTEIE TGSFVFKPEM EDIHMAIEGR LFELIGEAAG RLHTARSRND QVATDVHLFV 

       130        140        150        160        170        180 
KNACDKTINK IRTLQGTLLE QAEAHPQTAL PGYTHMQIAQ PVLLPHHLLA YFEMLERDCG 

       190        200        210        220        230        240 
RFTDARKRAD VMPLGSGALA GVPYPLDREM VAKELGFSAI SQNSLDAVSE RDFILEYLSD 

       250        260        270        280        290        300 
AAICQMHLSR LSEEMVIWSS AEYAFVELDD AYTTGSSIMP QKKNPDVAEL CRGKTGRVYG 

       310        320        330        340        350        360 
SLNTMLTVMK GLPLSYNRDL QEDKEPLFDC VDTLGDSLEV FAGMIKTAKF KPERMLRALE 

       370        380        390        400        410        420 
KGYVLATDIA DYLVGKGESF RNSHGIVARL VSYAVAQNKT FGELSLAEYR QFSNLFEKDI 

       430        440        450        460 
YAVDIKSALN ARNLPGGTAP KQIAQAIARA KKILAEAGVK N

« Hide

References

[1]"Complete sequence of Dehalococcoides sp. BAV1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ritalahti K.M., Loeffler F., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BAV1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000688 Genomic DNA. Translation: ABQ17652.1.
RefSeqYP_001214530.1. NC_009455.1.

3D structure databases

ProteinModelPortalA5FQ74.
ModBaseSearch...

Protein-protein interaction databases

STRING216389.DehaBAV1_1072.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ17652; ABQ17652; DehaBAV1_1072.
GeneID5132025.
KEGGdeb:DehaBAV1_1072.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHOG000242744.
KOK01755.
OMAKEGIFDA.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycDSP216389:GH6D-1123-MONOMER.
UniPathwayUPA00068; UER00114.

Family and domain databases

Gene3D1.10.275.10. 1 hit.
HAMAPMF_00006. Arg_succ_lyase.
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR024083. Fumarase/histidase_N.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERPTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. argH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_DEHSB
AccessionPrimary (citable) accession number: A5FQ74
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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