A5FPM3 (TRPC_DEHSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	DehaBAV1_1274

Organism

Dehalococcoides sp. (strain BAV1) [Complete proteome] [HAMAP]

Taxonomic identifier

216389 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000076418

Sequences

	Sequence		Length	Mass (Da)
	A5FPM3 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 6D94BECB7848CA8F	FASTA	259	28,980
	10 20 30 40 50 60 MILERIVTDN LPDLERRKMR LPLAKLQELV LDIPYPPIDM AMKLKGRQVR LIAEVKKASP 70 80 90 100 110 120 SKGIIRPDFD PVDIAGIYAR NGASAISVLT EEHHFMGSLD NLKKIRESGV ASKLPLLRKD 130 140 150 160 170 180 FIHDPYQVYE SRLYGADAIL LIVAMLSPER LQELLSLSHK LGMKCLVEVH TRSELEIALE 190 200 210 220 230 240 SNARIIGLNN RDLHTFKIDL TVTERLRPLI PPECIVVSES GIQTRADISR LEELGVDAVL 250 VGEALTASVD IAAKMRKLL

References

[1]

"Complete sequence of Dehalococcoides sp. BAV1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ritalahti K.M., Loeffler F., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BAV1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000688 Genomic DNA. Translation: ABQ17853.1.
RefSeq	YP_001214731.1. NC_009455.1.
3D structure databases
ProteinModelPortal	A5FPM3.
ModBase	Search...
Protein-protein interaction databases
STRING	A5FPM3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5131580.
GenomeReviews	Gene locus DehaBAV1_1274 in contig CP000688_GR.
KEGG	deb:DehaBAV1_1274.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
HOGENOM	HBG540956.
OMA	VESLGMT.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	DSP216389:DEHABAV1_1274-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_DEHSB

Accession

Primary (citable) accession number: A5FPM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	June 12, 2007
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program