A5FPC2 (ARGC_DEHSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	DehaBAV1_1371

Organism

Dehalococcoides sp. (strain BAV1) [Complete proteome] [HAMAP]

Taxonomic identifier

216389 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Dehalococcoidetes › Dehalococcoides

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000118057
Sites
	Active site	147	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5FPC2 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: BEE69BD1D191A885	FASTA	341	37,152
	10 20 30 40 50 60 MKKYKAGIIN VTGYAGLELA RILESHPSVE LCSVTGRSLA GKKLSDVFPY LHRLDLPITE 70 80 90 100 110 120 NLEGQVDVAF LALPHKEGAA LVPALLEKGM RVIDISADFR LKDPALYQAW YGFEHPCPGL 130 140 150 160 170 180 LEEAVYGLPE LKRKDIAGAR LVANPGCYPT SAILGLVPAF KSDLIEPSAI IDAKSGLSGS 190 200 210 220 230 240 GRTPTVKTIF CEADEDVCAY SIGTHRHQPE IAQELCRASG GVIPRVTFCP HLVPMSRGIL 250 260 270 280 290 300 STAYARLKQP VTDEEVKEIY RQFYKDEPFV KVTAEPPHTR YTRGTNMCFI YPVVDALNEQ 310 320 330 340 LIVISCIDNL VKGAAGQAVQ NMNIMLGLAE TEGLEAMATL P

References

[1]

"Complete sequence of Dehalococcoides sp. BAV1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Lowry S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Ritalahti K.M., Loeffler F., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BAV1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000688 Genomic DNA. Translation: ABQ17948.1.
RefSeq	YP_001214826.1. NC_009455.1.
3D structure databases
ProteinModelPortal	A5FPC2.
ModBase	Search...
Protein-protein interaction databases
STRING	A5FPC2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5131790.
GenomeReviews	Gene locus DehaBAV1_1371 in contig CP000688_GR.
KEGG	deb:DehaBAV1_1371.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	TAEDCTT.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	DSP216389:DEHABAV1_1371-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_DEHSB

Accession

Primary (citable) accession number: A5FPC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	June 12, 2007
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program