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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Dehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciDMCC216389:G1G8W-1445-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:DehaBAV1_1386
OrganismiDehalococcoides mccartyi (strain ATCC BAA-2100 / JCM 16839 / KCTC 5957 / BAV1)
Taxonomic identifieri216389 [NCBI]
Taxonomic lineageiBacteriaChloroflexiDehalococcoidiaDehalococcoidalesDehalococcoidaceaeDehalococcoides

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000772971 – 315Methionyl-tRNA formyltransferaseAdd BLAST315

Structurei

3D structure databases

ProteinModelPortaliA5FPB5
SMRiA5FPB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 118Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

A5FPB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMNELKIV FMGSPEFALT PLKMLLAEGY DICGVYTQPD RPAGRGRELC
60 70 80 90 100
PPPVKTLALE HGLAVYQPQS LKKPEEQAFL KELKPDVIVV AAYGLILPQA
110 120 130 140 150
VLDIPVYGVL NIHPSLLPRY RGATPVAATL LGGDEWAGVS LMKLEAGLDT
160 170 180 190 200
GPVYSRSMVA IRPEDTTPIL ADKLAFIGGC MLLELLSQIP SLPEPQVQDN
210 220 230 240 250
TQASYFGMVT KEMGLINWQT SAVEIERRVR AFFPWPGVFT TFNQKTLKIL
260 270 280 290 300
EAKPRNLGLG LKPSEVRVYE QSRVMVGSAS GELEIIRLQL EGKAGCSAAD
310
FVRGQRNFDG VNLGV
Length:315
Mass (Da):34,393
Last modified:June 12, 2007 - v1
Checksum:i17BC986E195D752A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000688 Genomic DNA Translation: ABQ17963.1
RefSeqiWP_012034267.1, NC_009455.1

Genome annotation databases

EnsemblBacteriaiABQ17963; ABQ17963; DehaBAV1_1386
KEGGideb:DehaBAV1_1386
PATRICifig|216389.18.peg.1459

Similar proteinsi

Entry informationi

Entry nameiFMT_DEHMB
AccessioniPrimary (citable) accession number: A5FPB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: March 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health