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A5FMT0

- GCSP_FLAJ1

UniProt

A5FMT0 - GCSP_FLAJ1

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciFJOH376686:GIXN-458-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Fjoh_0445
    OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
    Taxonomic identifieri376686 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
    ProteomesiUP000006694: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 949949Glycine dehydrogenase (decarboxylating)PRO_1000083207Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei700 – 7001N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi376686.Fjoh_0445.

    Structurei

    3D structure databases

    ProteinModelPortaliA5FMT0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5FMT0-1 [UniParc]FASTAAdd to Basket

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    MKTDAFALRH IGPRETDLQH MLQTIGVDSI EQLVYETLPD DIRLKAPLNL    50
    DPAMTEYEFA NHIQELGKKN KVFKSYIGLG YHPTIVPAPI QRNIFENPGW 100
    YTAYTPYQAE IAQGRLEAIL NFQTTVIELT GMEIANASLL DEGTAAAEAM 150
    ALLFDVRTRD QKKNNTHKFF VSEEILPQTL SVLQTRSTPI GIELVVGNHE 200
    TFDFSTEFFG AILQYPGKYG QVNDYGAFVA KAKENEIKVA FAADILSLAA 250
    LTSPGEMGAA VVVGTTQRFG VPMGYGGPHA AYFATKDEYK RSMPGRIIGV 300
    SVDANGNRAL RMALGTREQH IKREKATSNI CTAQVLLAVM AGMYAVYHGP 350
    KGLKYIANKV HASAVTTAEA LNKLGVFQTN TAFFDTILVK ADAQKVKAIA 400
    EKNEVNFFYP DAESVSISLN ETTSVSDINQ IIAIFAEALG KEAVTVSELT 450
    TASQLPASLE RTSSFLTHDV FNNHHSESQL MRYIKKLERK DLSLNHSMIS 500
    LGSCTMKLNA ASEMLPLSMP NWNSIHPFAP VEQAEGYITM LKKLEQQLNV 550
    ITGFAGTTLQ PNSGAQGEYA GLMAIRAYHL SRNEGHRNVC LIPSSAHGTN 600
    PASAAMAGMK IIVTKTTPEG NIDVEDLREK AIEHKDDLSC LMVTYPSTHG 650
    VFESSIIEIT KLIHENGGLV YMDGANMNAQ VGLTNPATIG ADVCHLNLHK 700
    TFAIPHGGGG PGVGPICVNE KLVPFLPTNP ILKVGGEQAI TAISSAPYGS 750
    ALVCLISYGY ITMMGAEGLK SATEHAILNA NYMKSRFEGH YPILYTGECG 800
    RAAHEMILDC RAFKENGIEV GDIAKRLMDY GFHAPTVSFP VAGTLMIEPT 850
    ESEDLAELDR FCDALISIRK EIEAATADDK NNVLKNAPHT LAMLTSDSWD 900
    FPYSREKAAY PLEYIADNKF WPSVRRVDDA YGDRNLVCSC APIEAYMEN 949
    Length:949
    Mass (Da):103,684
    Last modified:June 12, 2007 - v1
    Checksum:i8CE513D8C3C2F7E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000685 Genomic DNA. Translation: ABQ03481.1.
    RefSeqiYP_001192800.1. NC_009441.1.

    Genome annotation databases

    EnsemblBacteriaiABQ03481; ABQ03481; Fjoh_0445.
    GeneIDi5089959.
    KEGGifjo:Fjoh_0445.
    PATRICi21895133. VBIFlaJoh53613_0458.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000685 Genomic DNA. Translation: ABQ03481.1 .
    RefSeqi YP_001192800.1. NC_009441.1.

    3D structure databases

    ProteinModelPortali A5FMT0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 376686.Fjoh_0445.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ03481 ; ABQ03481 ; Fjoh_0445 .
    GeneIDi 5089959.
    KEGGi fjo:Fjoh_0445.
    PATRICi 21895133. VBIFlaJoh53613_0458.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci FJOH376686:GIXN-458-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Novel features of the polysaccharide-digesting gliding bacterium Flavobacterium johnsoniae as revealed by genome sequence analysis."
      McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G., Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R., Cheng Y.Q., Stein J.L.
      Appl. Environ. Microbiol. 75:6864-6875(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17061 / DSM 2064 / UW101.

    Entry informationi

    Entry nameiGCSP_FLAJ1
    AccessioniPrimary (citable) accession number: A5FMT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3