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A5FMT0 (GCSP_FLAJ1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Fjoh_0445
OrganismFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae) [Complete proteome] [HAMAP]
Taxonomic identifier376686 [NCBI]
Taxonomic lineageBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium

Protein attributes

Sequence length949 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 949949Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000083207

Amino acid modifications

Modified residue7001N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A5FMT0 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 8CE513D8C3C2F7E9

FASTA949103,684
        10         20         30         40         50         60 
MKTDAFALRH IGPRETDLQH MLQTIGVDSI EQLVYETLPD DIRLKAPLNL DPAMTEYEFA 

        70         80         90        100        110        120 
NHIQELGKKN KVFKSYIGLG YHPTIVPAPI QRNIFENPGW YTAYTPYQAE IAQGRLEAIL 

       130        140        150        160        170        180 
NFQTTVIELT GMEIANASLL DEGTAAAEAM ALLFDVRTRD QKKNNTHKFF VSEEILPQTL 

       190        200        210        220        230        240 
SVLQTRSTPI GIELVVGNHE TFDFSTEFFG AILQYPGKYG QVNDYGAFVA KAKENEIKVA 

       250        260        270        280        290        300 
FAADILSLAA LTSPGEMGAA VVVGTTQRFG VPMGYGGPHA AYFATKDEYK RSMPGRIIGV 

       310        320        330        340        350        360 
SVDANGNRAL RMALGTREQH IKREKATSNI CTAQVLLAVM AGMYAVYHGP KGLKYIANKV 

       370        380        390        400        410        420 
HASAVTTAEA LNKLGVFQTN TAFFDTILVK ADAQKVKAIA EKNEVNFFYP DAESVSISLN 

       430        440        450        460        470        480 
ETTSVSDINQ IIAIFAEALG KEAVTVSELT TASQLPASLE RTSSFLTHDV FNNHHSESQL 

       490        500        510        520        530        540 
MRYIKKLERK DLSLNHSMIS LGSCTMKLNA ASEMLPLSMP NWNSIHPFAP VEQAEGYITM 

       550        560        570        580        590        600 
LKKLEQQLNV ITGFAGTTLQ PNSGAQGEYA GLMAIRAYHL SRNEGHRNVC LIPSSAHGTN 

       610        620        630        640        650        660 
PASAAMAGMK IIVTKTTPEG NIDVEDLREK AIEHKDDLSC LMVTYPSTHG VFESSIIEIT 

       670        680        690        700        710        720 
KLIHENGGLV YMDGANMNAQ VGLTNPATIG ADVCHLNLHK TFAIPHGGGG PGVGPICVNE 

       730        740        750        760        770        780 
KLVPFLPTNP ILKVGGEQAI TAISSAPYGS ALVCLISYGY ITMMGAEGLK SATEHAILNA 

       790        800        810        820        830        840 
NYMKSRFEGH YPILYTGECG RAAHEMILDC RAFKENGIEV GDIAKRLMDY GFHAPTVSFP 

       850        860        870        880        890        900 
VAGTLMIEPT ESEDLAELDR FCDALISIRK EIEAATADDK NNVLKNAPHT LAMLTSDSWD 

       910        920        930        940 
FPYSREKAAY PLEYIADNKF WPSVRRVDDA YGDRNLVCSC APIEAYMEN 

« Hide

References

[1]"Complete sequence of Flavobacterium johnsoniae UW101."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Xie G., McBride M., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17061 / DSM 2064 / UW101.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000685 Genomic DNA. Translation: ABQ03481.1.
RefSeqYP_001192800.1. NC_009441.1.

3D structure databases

ProteinModelPortalA5FMT0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING376686.Fjoh_0445.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ03481; ABQ03481; Fjoh_0445.
GeneID5089959.
KEGGfjo:Fjoh_0445.
PATRIC21895133. VBIFlaJoh53613_0458.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycFJOH376686:GIXN-458-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_FLAJ1
AccessionPrimary (citable) accession number: A5FMT0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families