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A5FMT0

- GCSP_FLAJ1

UniProt

A5FMT0 - GCSP_FLAJ1

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Fjoh_0445
Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciFJOH376686:GIXN-458-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Fjoh_0445
OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Taxonomic identifieri376686 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
ProteomesiUP000006694: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000083207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei700 – 7001N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi376686.Fjoh_0445.

Structurei

3D structure databases

ProteinModelPortaliA5FMT0.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A5FMT0-1 [UniParc]FASTAAdd to Basket

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MKTDAFALRH IGPRETDLQH MLQTIGVDSI EQLVYETLPD DIRLKAPLNL    50
DPAMTEYEFA NHIQELGKKN KVFKSYIGLG YHPTIVPAPI QRNIFENPGW 100
YTAYTPYQAE IAQGRLEAIL NFQTTVIELT GMEIANASLL DEGTAAAEAM 150
ALLFDVRTRD QKKNNTHKFF VSEEILPQTL SVLQTRSTPI GIELVVGNHE 200
TFDFSTEFFG AILQYPGKYG QVNDYGAFVA KAKENEIKVA FAADILSLAA 250
LTSPGEMGAA VVVGTTQRFG VPMGYGGPHA AYFATKDEYK RSMPGRIIGV 300
SVDANGNRAL RMALGTREQH IKREKATSNI CTAQVLLAVM AGMYAVYHGP 350
KGLKYIANKV HASAVTTAEA LNKLGVFQTN TAFFDTILVK ADAQKVKAIA 400
EKNEVNFFYP DAESVSISLN ETTSVSDINQ IIAIFAEALG KEAVTVSELT 450
TASQLPASLE RTSSFLTHDV FNNHHSESQL MRYIKKLERK DLSLNHSMIS 500
LGSCTMKLNA ASEMLPLSMP NWNSIHPFAP VEQAEGYITM LKKLEQQLNV 550
ITGFAGTTLQ PNSGAQGEYA GLMAIRAYHL SRNEGHRNVC LIPSSAHGTN 600
PASAAMAGMK IIVTKTTPEG NIDVEDLREK AIEHKDDLSC LMVTYPSTHG 650
VFESSIIEIT KLIHENGGLV YMDGANMNAQ VGLTNPATIG ADVCHLNLHK 700
TFAIPHGGGG PGVGPICVNE KLVPFLPTNP ILKVGGEQAI TAISSAPYGS 750
ALVCLISYGY ITMMGAEGLK SATEHAILNA NYMKSRFEGH YPILYTGECG 800
RAAHEMILDC RAFKENGIEV GDIAKRLMDY GFHAPTVSFP VAGTLMIEPT 850
ESEDLAELDR FCDALISIRK EIEAATADDK NNVLKNAPHT LAMLTSDSWD 900
FPYSREKAAY PLEYIADNKF WPSVRRVDDA YGDRNLVCSC APIEAYMEN 949
Length:949
Mass (Da):103,684
Last modified:June 12, 2007 - v1
Checksum:i8CE513D8C3C2F7E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000685 Genomic DNA. Translation: ABQ03481.1.
RefSeqiYP_001192800.1. NC_009441.1.

Genome annotation databases

EnsemblBacteriaiABQ03481; ABQ03481; Fjoh_0445.
GeneIDi5089959.
KEGGifjo:Fjoh_0445.
PATRICi21895133. VBIFlaJoh53613_0458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000685 Genomic DNA. Translation: ABQ03481.1 .
RefSeqi YP_001192800.1. NC_009441.1.

3D structure databases

ProteinModelPortali A5FMT0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 376686.Fjoh_0445.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ03481 ; ABQ03481 ; Fjoh_0445 .
GeneIDi 5089959.
KEGGi fjo:Fjoh_0445.
PATRICi 21895133. VBIFlaJoh53613_0458.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci FJOH376686:GIXN-458-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Novel features of the polysaccharide-digesting gliding bacterium Flavobacterium johnsoniae as revealed by genome sequence analysis."
    McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G., Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R., Cheng Y.Q., Stein J.L.
    Appl. Environ. Microbiol. 75:6864-6875(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17061 / DSM 2064 / UW101.

Entry informationi

Entry nameiGCSP_FLAJ1
AccessioniPrimary (citable) accession number: A5FMT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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