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A5FMT0

- GCSP_FLAJ1

UniProt

A5FMT0 - GCSP_FLAJ1

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciFJOH376686:GIXN-458-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Fjoh_0445
OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Taxonomic identifieri376686 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
ProteomesiUP000006694: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949Glycine dehydrogenase (decarboxylating)PRO_1000083207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei700 – 7001N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi376686.Fjoh_0445.

Structurei

3D structure databases

ProteinModelPortaliA5FMT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A5FMT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTDAFALRH IGPRETDLQH MLQTIGVDSI EQLVYETLPD DIRLKAPLNL
60 70 80 90 100
DPAMTEYEFA NHIQELGKKN KVFKSYIGLG YHPTIVPAPI QRNIFENPGW
110 120 130 140 150
YTAYTPYQAE IAQGRLEAIL NFQTTVIELT GMEIANASLL DEGTAAAEAM
160 170 180 190 200
ALLFDVRTRD QKKNNTHKFF VSEEILPQTL SVLQTRSTPI GIELVVGNHE
210 220 230 240 250
TFDFSTEFFG AILQYPGKYG QVNDYGAFVA KAKENEIKVA FAADILSLAA
260 270 280 290 300
LTSPGEMGAA VVVGTTQRFG VPMGYGGPHA AYFATKDEYK RSMPGRIIGV
310 320 330 340 350
SVDANGNRAL RMALGTREQH IKREKATSNI CTAQVLLAVM AGMYAVYHGP
360 370 380 390 400
KGLKYIANKV HASAVTTAEA LNKLGVFQTN TAFFDTILVK ADAQKVKAIA
410 420 430 440 450
EKNEVNFFYP DAESVSISLN ETTSVSDINQ IIAIFAEALG KEAVTVSELT
460 470 480 490 500
TASQLPASLE RTSSFLTHDV FNNHHSESQL MRYIKKLERK DLSLNHSMIS
510 520 530 540 550
LGSCTMKLNA ASEMLPLSMP NWNSIHPFAP VEQAEGYITM LKKLEQQLNV
560 570 580 590 600
ITGFAGTTLQ PNSGAQGEYA GLMAIRAYHL SRNEGHRNVC LIPSSAHGTN
610 620 630 640 650
PASAAMAGMK IIVTKTTPEG NIDVEDLREK AIEHKDDLSC LMVTYPSTHG
660 670 680 690 700
VFESSIIEIT KLIHENGGLV YMDGANMNAQ VGLTNPATIG ADVCHLNLHK
710 720 730 740 750
TFAIPHGGGG PGVGPICVNE KLVPFLPTNP ILKVGGEQAI TAISSAPYGS
760 770 780 790 800
ALVCLISYGY ITMMGAEGLK SATEHAILNA NYMKSRFEGH YPILYTGECG
810 820 830 840 850
RAAHEMILDC RAFKENGIEV GDIAKRLMDY GFHAPTVSFP VAGTLMIEPT
860 870 880 890 900
ESEDLAELDR FCDALISIRK EIEAATADDK NNVLKNAPHT LAMLTSDSWD
910 920 930 940
FPYSREKAAY PLEYIADNKF WPSVRRVDDA YGDRNLVCSC APIEAYMEN
Length:949
Mass (Da):103,684
Last modified:June 12, 2007 - v1
Checksum:i8CE513D8C3C2F7E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000685 Genomic DNA. Translation: ABQ03481.1.
RefSeqiWP_012022537.1. NC_009441.1.
YP_001192800.1. NC_009441.1.

Genome annotation databases

EnsemblBacteriaiABQ03481; ABQ03481; Fjoh_0445.
GeneIDi5089959.
KEGGifjo:Fjoh_0445.
PATRICi21895133. VBIFlaJoh53613_0458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000685 Genomic DNA. Translation: ABQ03481.1 .
RefSeqi WP_012022537.1. NC_009441.1.
YP_001192800.1. NC_009441.1.

3D structure databases

ProteinModelPortali A5FMT0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 376686.Fjoh_0445.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ03481 ; ABQ03481 ; Fjoh_0445 .
GeneIDi 5089959.
KEGGi fjo:Fjoh_0445.
PATRICi 21895133. VBIFlaJoh53613_0458.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci FJOH376686:GIXN-458-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Novel features of the polysaccharide-digesting gliding bacterium Flavobacterium johnsoniae as revealed by genome sequence analysis."
    McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G., Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R., Cheng Y.Q., Stein J.L.
    Appl. Environ. Microbiol. 75:6864-6875(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17061 / DSM 2064 / UW101.

Entry informationi

Entry nameiGCSP_FLAJ1
AccessioniPrimary (citable) accession number: A5FMT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3