Reviewed, UniProtKB/Swiss-Prot A5FMP6 (KMO_FLAJ1)

Names and origin

Protein names

Recommended name:
    Kynurenine 3-monooxygenase
    EC=1.14.13.9
Alternative name(s):
    Kynurenine 3-hydroxylase

Gene names

Name:	kmo
Ordered Locus Names:	Fjoh_0495

Organism

Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae) [Complete proteome] [HAMAP]

Taxonomic identifier

376686 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteria › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Kynurenine 3-monooxygenase		PRO_0000361936

Sequences

	Sequence		Length	Mass (Da)
	A5FMP6-1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 81BDC6008A8800E8	FASTA	446	51,241
	10 20 30 40 50 60 MQTSLKIAVV GSGLVGSLLA IYLKKAGHTV HVYDRSPDIR KINFSGRSIN LAMSNRGWKA 70 80 90 100 110 120 LDGVGVGDAV REIAIPMDKR AIHLVDKLNF QNYGQEGESI YSISRGTLNR KMIDLAENAG 130 140 150 160 170 180 AEFYFEQKIW DVTLSDATLH IGESERGEWE ERKYDMVFGA DGAFSRIRHR MQRQSMFNYS 190 200 210 220 230 240 QEFLNMGYKE LNIPANADRT HKLDKNSFHI WPRGEYMLIA LPNLDGSFTC TLFMPFEGEN 250 260 270 280 290 300 SFESLTDRKM VEDFFEKNFP DSIEVIPELA NDFFKNPTST LVTMKCFPWT YEDKIALIGD 310 320 330 340 350 360 ACHAIVPFYG QGMNAGFEDI TVLNEMIEKF GDDWKKIFTE YQISRKPNAD AIAELSYRNF 370 380 390 400 410 420 MEMSTKTADE KFLLQKKIEK VFSDKHPDKW IPLYSRVTFS DRPYAEALAI GDFQNGIMEE 430 440 VLKLDNIENI WNTPEVENKI LELLQK

References

[1]

"Complete sequence of Flavobacterium johnsoniae UW101." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Xie G., McBride M., Richardson P. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000685 Genomic DNA. Translation: ABQ03530.1.
RefSeq	YP_001192849.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A5FMP6.
Genome annotation databases
GeneID	5089808.
GenomeReviews	Gene locus Fjoh_0495 in contig CP000685_GR.
KEGG	fjo:Fjoh_0495.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HTDVLAD.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. IPR003042. Rng_hydrolase-like. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_FLAJ1

Accession

Primary (citable) accession number: A5FMP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 12, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)