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A5FMP6 (KMO_FLAJ1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Kynurenine 3-monooxygenase
EC=1.14.13.9
Alternative name(s):
Kynurenine 3-hydroxylase
Gene names
Name:kmo
Ordered Locus Names:Fjoh_0495
OrganismFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae) [Complete proteome] [HAMAP]
Taxonomic identifier376686 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.

Catalytic activity

L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.

Cofactor

FAD By similarity.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.

Sequence similarities

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   LigandFAD
Flavoprotein
NADP
   Molecular functionMonooxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpyridine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionkynurenine 3-monooxygenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Kynurenine 3-monooxygenase
PRO_0000361936

Sequences

Sequence LengthMass (Da)Tools
A5FMP6 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 81BDC6008A8800E8

FASTA44651,241
        10         20         30         40         50         60 
MQTSLKIAVV GSGLVGSLLA IYLKKAGHTV HVYDRSPDIR KINFSGRSIN LAMSNRGWKA 

        70         80         90        100        110        120 
LDGVGVGDAV REIAIPMDKR AIHLVDKLNF QNYGQEGESI YSISRGTLNR KMIDLAENAG 

       130        140        150        160        170        180 
AEFYFEQKIW DVTLSDATLH IGESERGEWE ERKYDMVFGA DGAFSRIRHR MQRQSMFNYS 

       190        200        210        220        230        240 
QEFLNMGYKE LNIPANADRT HKLDKNSFHI WPRGEYMLIA LPNLDGSFTC TLFMPFEGEN 

       250        260        270        280        290        300 
SFESLTDRKM VEDFFEKNFP DSIEVIPELA NDFFKNPTST LVTMKCFPWT YEDKIALIGD 

       310        320        330        340        350        360 
ACHAIVPFYG QGMNAGFEDI TVLNEMIEKF GDDWKKIFTE YQISRKPNAD AIAELSYRNF 

       370        380        390        400        410        420 
MEMSTKTADE KFLLQKKIEK VFSDKHPDKW IPLYSRVTFS DRPYAEALAI GDFQNGIMEE 

       430        440 
VLKLDNIENI WNTPEVENKI LELLQK

« Hide

References

[1]"Complete sequence of Flavobacterium johnsoniae UW101."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Xie G., McBride M., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17061 / DSM 2064 / UW101.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000685 Genomic DNA. Translation: ABQ03530.1.
RefSeqYP_001192849.1. NC_009441.1.

3D structure databases

ProteinModelPortalA5FMP6.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5FMP6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5089808.
GenomeReviewsGene locus Fjoh_0495 in contig CP000685_GR.
KEGGfjo:Fjoh_0495.
PATRIC21895251. VBIFlaJoh53613_0512.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0654.
HOGENOMHBG430104.
OMAWGYKELT.
ProtClustDBCLSK903475.

Enzyme and pathway databases

BioCycFJOH376686:FJOH_0495-MONOMER.

Family and domain databases

InterProIPR002938. mOase_FAD-bd.
IPR003042. Rng_hydrolase-like.
[Graphical view]
KOK00486.
PfamPF01494. FAD_binding_3. 1 hit.
[Graphical view]
PRINTSPR00420. RNGMNOXGNASE.
ProtoNetSearch...

Entry information

Entry nameKMO_FLAJ1
AccessionPrimary (citable) accession number: A5FMP6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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