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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei732ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFJOH376686:G1G8T-593-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Fjoh_0565
OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Taxonomic identifieri376686 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
Proteomesi
  • UP000006694 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000748331 – 954Leucine--tRNA ligaseAdd BLAST954

Proteomic databases

PRIDEiA5FMG2

Interactioni

Protein-protein interaction databases

STRINGi376686.Fjoh_0565

Structurei

3D structure databases

ProteinModelPortaliA5FMG2
SMRiA5FMG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi729 – 733"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A5FMG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYNPNEIEA KWQKYWAENQ TFAAKNNSEK PKHYVLDMFP YPSGAGLHVG
60 70 80 90 100
HPLGYIASDV YSRFKRHQGF NVLHPMGYDS FGLPAEQYAI QTGQRPEDTT
110 120 130 140 150
RVNIDGGVDK EGKQIAGYRK QLDKIGFSFD WAREVRTSNP DYYKHTQWIF
160 170 180 190 200
IQLFNSWYCR KQGKAFDISE LVTVFEESGN ALVEAVCDDN VTIFTADEWK
210 220 230 240 250
SYSDDQKEKI LLQYRMTYLA ETEVNWCPGL GTVLANDEIV NGVSERGGFP
260 270 280 290 300
VIRKKMTQWS MRISAYAERL LQGLNDIDWS ESIKESQRNW IGKSVGALVT
310 320 330 340 350
FNVKNHDEVI EVFTTRPDTI FGVTFMTLAP EHDLVAKITT PEQKEAVEAY
360 370 380 390 400
IEKTAKRSER ERMADVKTIS GVFTGAYAEH PFTKEAIPVW IGDYVLAGYG
410 420 430 440 450
TGAVMAVPCG DERDYAFANF FKGQNGMQEI KNIFANVDIS EAAYGSKDNV
460 470 480 490 500
EIAASDFLNG LNYKDATAKA IYKLEEIGQG KGKTNYRLRD AVFSRQRYWG
510 520 530 540 550
EPFPVYYVNG LPKMIDTQHL PIILPEVEKY LPTEDGLPPL GNAAVWAWDI
560 570 580 590 600
KENKVVNTDL VDNVSIFPLE LNTMPGWAGS SWYWMRYMDA HNENEFASKE
610 620 630 640 650
ALAYWENVDL YIGGSEHATG HLLYSRFWNK FLKDKGFAPT EEPFKKLINQ
660 670 680 690 700
GMILGTTAYV YRLEGTNTFV SKNKIKGQNV QPIRVDVHFV NSSDELNIEK
710 720 730 740 750
FKAWREDFNT AEFIFDENGK YIVGREVEKM SKSYYNVVTP DDICAEYGAD
760 770 780 790 800
TLRLYEMFLG PLEQAKPWNT AGISGVFGFL KKLWRLYFDD NGLIVNNDEP
810 820 830 840 850
TKDNLKSLHK TIKKVAEDIE NFSFNTSVSQ FMICVNELSS QNCHSRAILE
860 870 880 890 900
PLAILVSPYA PHIAEELWAQ LGHKTSISEV AFPVFDAKHL VETNKEYPVS
910 920 930 940 950
FNGKMRFTIE LPLDLTAAQI EEIVMKDERT QKQLDGRIPN KVIIVPGKII

NLVG
Length:954
Mass (Da):108,655
Last modified:June 12, 2007 - v1
Checksum:iD29CBF67221F04B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000685 Genomic DNA Translation: ABQ03600.1
RefSeqiWP_012022656.1, NZ_MUGZ01000026.1

Genome annotation databases

EnsemblBacteriaiABQ03600; ABQ03600; Fjoh_0565
GeneIDi31763437
KEGGifjo:Fjoh_0565

Similar proteinsi

Entry informationi

Entry nameiSYL_FLAJ1
AccessioniPrimary (citable) accession number: A5FMG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
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