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Protein

Thymidine kinase

Gene

tdk

Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28ATPUniRule annotation8
Nucleotide bindingi93 – 96ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Fjoh_0586Imported
ORF Names:B0A63_23040Imported
OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)Imported
Taxonomic identifieri376686 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
Proteomesi
  • UP000006694 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi376686.Fjoh_0586.

Structurei

3D structure databases

ProteinModelPortaliA5FME9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T8J. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiKEQFGWI.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A5FME9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLENTVNHK EQFGWIEVIC GSMFSGKTEE LIRRLKRAQF AKQRVEIFKP
60 70 80 90 100
AIDTRYHDEM VVSHDANEIR STPVPAAANI SILAQGCDVV GIDEAQFFDD
110 120 130 140 150
EIVTVCNDLA NRGVRVIVAG LDMDFKGNPF GPMPALMATA EYVTKVHAVC
160 170 180 190
TRTGNLANYS FRKTDNDKLV MLGETEEYEP LSRAAYFNAM KKNQ
Length:194
Mass (Da):21,788
Last modified:June 12, 2007 - v1
Checksum:i7751DD4FCD837FEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000685 Genomic DNA. Translation: ABQ03621.1.
MUGZ01000026 Genomic DNA. Translation: OXE96040.1.
RefSeqiWP_012022677.1. NZ_MUGZ01000026.1.

Genome annotation databases

EnsemblBacteriaiABQ03621; ABQ03621; Fjoh_0586.
GeneIDi31763458.
KEGGifjo:Fjoh_0586.

Similar proteinsi

Entry informationi

Entry nameiA5FME9_FLAJ1
AccessioniPrimary (citable) accession number: A5FME9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: November 22, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported