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Protein

Thymidine kinase

Gene

tdk

Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28ATPUniRule annotation8
Nucleotide bindingi93 – 96ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciFJOH376686:G1G8T-614-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Fjoh_0586Imported
OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)Imported
Taxonomic identifieri376686 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
Proteomesi
  • UP000006694 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi376686.Fjoh_0586

Structurei

3D structure databases

ProteinModelPortaliA5FME9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T8J Bacteria
COG1435 LUCA
HOGENOMiHOG000076390
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

A5FME9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLENTVNHK EQFGWIEVIC GSMFSGKTEE LIRRLKRAQF AKQRVEIFKP
60 70 80 90 100
AIDTRYHDEM VVSHDANEIR STPVPAAANI SILAQGCDVV GIDEAQFFDD
110 120 130 140 150
EIVTVCNDLA NRGVRVIVAG LDMDFKGNPF GPMPALMATA EYVTKVHAVC
160 170 180 190
TRTGNLANYS FRKTDNDKLV MLGETEEYEP LSRAAYFNAM KKNQ
Length:194
Mass (Da):21,788
Last modified:June 12, 2007 - v1
Checksum:i7751DD4FCD837FEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000685 Genomic DNA Translation: ABQ03621.1
RefSeqiWP_012022677.1, NZ_MUGZ01000026.1

Genome annotation databases

EnsemblBacteriaiABQ03621; ABQ03621; Fjoh_0586
GeneIDi31763458
KEGGifjo:Fjoh_0586

Similar proteinsi

Entry informationi

Entry nameiA5FME9_FLAJ1
AccessioniPrimary (citable) accession number: A5FME9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health