Skip Header

Contribute Send feedback
Read comments (?) or add your own

A5FM42 (A5FM42_FLAJ1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Lipoprotein signal peptidase HAMAP MF_00161
EC=3.4.23.36 HAMAP MF_00161
Alternative name(s):
Prolipoprotein signal peptidase HAMAP MF_00161
Signal peptidase II HAMAP MF_00161
Gene names
Name:lspA HAMAP MF_00161
Ordered Locus Names:Fjoh_0700
OrganismFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae) [Complete proteome] [HAMAP]
Taxonomic identifier376686 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity. HAMAP MF_00161 SAAS SAAS001872

Catalytic activity

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. HAMAP MF_00161 SAAS SAAS001872

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage). HAMAP MF_00161 SAAS SAAS001872

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00161.

Sequence similarities

Belongs to the peptidase A8 family. HAMAP MF_00161

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Transmembrane6 – 2621Helical; By similarity HAMAP MF_00161
Transmembrane61 – 8121Helical; By similarity HAMAP MF_00161
Transmembrane92 – 11221Helical; By similarity HAMAP MF_00161
Transmembrane168 – 18821Helical; By similarity HAMAP MF_00161

Sites

Active site1091 By similarity HAMAP MF_00161
Active site1771 By similarity HAMAP MF_00161

Sequences

Sequence LengthMass (Da)Tools
A5FM42 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 73660D863014D677

FASTA19922,619
        10         20         30         40         50         60 
MSLRKAYFLI FLVLIVDQLS KIYVKTNFVL GDEVVIFDWF RIHFIENEGM AWGTRIPGEY 

        70         80         90        100        110        120 
GKLILTVFRI FAVCGIGYWL ADSVKKRHST YLIVSIALIF AGAAGNIIDS VFYGVIFDDS 

       130        140        150        160        170        180 
THNLATIFSP HPYGTWFHGL VVDMFYFPIW EGDLPAWLPI FGGKHFMFFN AIFNVADMAI 

       190 
STGVGILLVF NKRAFPKHA

« Hide

References

[1]"Complete sequence of Flavobacterium johnsoniae UW101."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Xie G., McBride M., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17061 / DSM 2064 / UW101.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000685 Genomic DNA. Translation: ABQ03735.1.
RefSeqYP_001193054.1. NC_009441.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA5FM42.

Protein family/group databases

MEROPSA08.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5090734.
GenomeReviewsGene locus Fjoh_0700 in contig CP000685_GR.
KEGGfjo:Fjoh_0700.
PATRIC21895671. VBIFlaJoh53613_0720.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG78647.
HOGENOMHBG724422.
OMAHGKVVDM.
ProtClustDBPRK14788.

Family and domain databases

HAMAPMF_00161. LspA.
[Tree]
InterProIPR001872. Peptidase_A8.
[Graphical view]
KOK03101.
PfamPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSPR00781. LIPOSIGPTASE.
ProtoNetSearch...

Entry information

Entry nameA5FM42_FLAJ1
AccessionPrimary (citable) accession number: A5FM42
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info