Skip Header

Contribute Send feedback
Read comments (?) or add your own

A5FJK3 (SAHH_FLAJ1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosylhomocysteinase
EC=3.3.1.1
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name=AdoHcyase
Gene names
Name:ahcY
Ordered Locus Names:Fjoh_1579
OrganismFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae) [Complete proteome] [HAMAP]
Taxonomic identifier376686 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine By similarity. HAMAP MF_00563

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563

Cofactor

Binds 1 NAD per subunit By similarity. HAMAP MF_00563

Pathway

Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563

Subcellular location

Cytoplasm By similarity HAMAP MF_00563.

Sequence similarities

Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Adenosylhomocysteinase HAMAP MF_00563
PRO_1000082278

Regions

Nucleotide binding163 – 1653NAD By similarity
Nucleotide binding226 – 2316NAD By similarity
Nucleotide binding305 – 3073NAD By similarity

Sites

Binding site611Substrate By similarity
Binding site1371Substrate By similarity
Binding site1621Substrate By similarity
Binding site1921Substrate By similarity
Binding site1961Substrate By similarity
Binding site1971NAD By similarity
Binding site2491NAD By similarity
Binding site2841NAD By similarity
Binding site3521NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A5FJK3 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 35E5C39F5927BB05

FASTA43848,002
        10         20         30         40         50         60 
MSTTTTPYVA FKVKDISLAA WGRKEIELAE AEMPGLMALR AEYKDEQPLK GARIAGCLHM 

        70         80         90        100        110        120 
TIQTAVLIET LIALGAEVTW SSCNIFSTQD QAAAAIAAAG ISVYAWKGLD EESFDWCIEQ 

       130        140        150        160        170        180 
TLFFGEERKP LNMILDDGGD LTNMVIDRYP ELVAGIKGLS EETTTGVHRL YERVKAGTLP 

       190        200        210        220        230        240 
MPAININDSV TKSKFDNKYG CKESAVDAVR RATDLMLAGK RVVVCGYGDV GKGTAASFRG 

       250        260        270        280        290        300 
AGSIVTVTEI DPICALQAAM DGYEVKKLNT VIANADIIIT TTGNKDIVLG EHFEQMKDKT 

       310        320        330        340        350        360 
VVCNIGHFDN EIDMAWLNKN HGASKIEIKP QVDKYNINGK DIIILAEGRL VNLGCATGHP 

       370        380        390        400        410        420 
SFVMSNSFTN QTLAQIELWN NSAAYKNEVY MLPKHLDEKV AALHLAKLGV ELEVLREDQA 

       430 
AYIGVEVQGP FKPEYYRY

« Hide

References

[1]"Complete sequence of Flavobacterium johnsoniae UW101."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Xie G., McBride M., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17061 / DSM 2064 / UW101.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000685 Genomic DNA. Translation: ABQ04611.1.
RefSeqYP_001193930.1. NC_009441.1.

3D structure databases

ProteinModelPortalA5FJK3.
SMRA5FJK3. Positions 11-438.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5FJK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5092683.
GenomeReviewsGene locus Fjoh_1579 in contig CP000685_GR.
KEGGfjo:Fjoh_1579.
PATRIC21897497. VBIFlaJoh53613_1624.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0499.
HOGENOMHBG352029.
OMASAQVWVT.
ProtClustDBPRK05476.

Enzyme and pathway databases

BioCycFJOH376686:FJOH_1579-MONOMER.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSAHH_FLAJ1
AccessionPrimary (citable) accession number: A5FJK3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents