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Protein

Holliday junction ATP-dependent DNA helicase RuvB

Gene

ruvB

Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 69ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
Biological processDNA damage, DNA recombination, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvBUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvBUniRule annotation
Ordered Locus Names:Fjoh_1642
OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Taxonomic identifieri376686 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
Proteomesi
  • UP000006694 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000740841 – 340Holliday junction ATP-dependent DNA helicase RuvBAdd BLAST340

Interactioni

Subunit structurei

Forms a complex with RuvA.UniRule annotation

Protein-protein interaction databases

STRINGi376686.Fjoh_1642.

Structurei

3D structure databases

ProteinModelPortaliA5FJE5.
SMRiA5FJE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKJ. Bacteria.
COG2255. LUCA.
HOGENOMiHOG000218623.
KOiK03551.
OMAiDEIHRMS.
OrthoDBiPOG091H00GH.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00016. DNA_helic_RuvB. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR004605. DNA_helicase_Holl-junc_RuvB.
IPR008823. DNA_helicase_Holl-junc_RuvB_C.
IPR027417. P-loop_NTPase.
IPR008824. RuvB_N.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR42848. PTHR42848. 1 hit.
PfamiView protein in Pfam
PF05491. RuvB_C. 1 hit.
PF05496. RuvB_N. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00635. ruvB. 1 hit.

Sequencei

Sequence statusi: Complete.

A5FJE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNENLDPTTK GYNSEELDLE KRLRPLSFDD FAGQDQVLEN LKVFVAAANQ
60 70 80 90 100
RGEALDHALF HGPPGLGKTT LANILANELE VGIKITSGPV LDKPGDLAGL
110 120 130 140 150
LTNLDERDVL FIDEIHRLSP IVEEYLYSAM EDFKIDIMIE SGPNARTVQI
160 170 180 190 200
NLNPFTLIGA TTRSGLLTAP MRARFGISSR LQYYSTELLT TIVERSAGIL
210 220 230 240 250
KMPIDLEAAI EIAGRSRGTP RIANALLRRV RDFAQIKGNG TIDLEISKYA
260 270 280 290 300
LKALNVDAHG LDEMDNKILL TIINKFKGGP VGLSTLATAV SESSETIEEV
310 320 330 340
YEPFLIQEGF IMRTPRGREV TEKAYKHLGK INTNIQGGLF
Length:340
Mass (Da):37,438
Last modified:June 12, 2007 - v1
Checksum:i621B9E4E06A79C96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000685 Genomic DNA. Translation: ABQ04674.1.
RefSeqiWP_012023718.1. NC_009441.1.

Genome annotation databases

EnsemblBacteriaiABQ04674; ABQ04674; Fjoh_1642.
GeneIDi31764523.
KEGGifjo:Fjoh_1642.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRUVB_FLAJ1
AccessioniPrimary (citable) accession number: A5FJE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: June 7, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families