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Protein

Holliday junction ATP-dependent DNA helicase RuvB

Gene

ruvB

Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 69ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
Biological processDNA damage, DNA recombination, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFJOH376686:G1G8T-1715-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvBUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvBUniRule annotation
Ordered Locus Names:Fjoh_1642
OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Taxonomic identifieri376686 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
Proteomesi
  • UP000006694 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000740841 – 340Holliday junction ATP-dependent DNA helicase RuvBAdd BLAST340

Proteomic databases

PRIDEiA5FJE5

Interactioni

Subunit structurei

Forms a complex with RuvA.UniRule annotation

Protein-protein interaction databases

STRINGi376686.Fjoh_1642

Structurei

3D structure databases

ProteinModelPortaliA5FJE5
SMRiA5FJE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKJ Bacteria
COG2255 LUCA
HOGENOMiHOG000218623
KOiK03551
OMAiDEIHRMS
OrthoDBiPOG091H00GH

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00016 DNA_helic_RuvB, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR004605 DNA_helicase_Holl-junc_RuvB
IPR008823 DNA_helicase_Holl-junc_RuvB_C
IPR027417 P-loop_NTPase
IPR008824 RuvB_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR42848 PTHR42848, 1 hit
PfamiView protein in Pfam
PF05491 RuvB_C, 1 hit
PF05496 RuvB_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005323 DNA_helicase_Holl-junc_RuvB_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00635 ruvB, 1 hit

Sequencei

Sequence statusi: Complete.

A5FJE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNENLDPTTK GYNSEELDLE KRLRPLSFDD FAGQDQVLEN LKVFVAAANQ
60 70 80 90 100
RGEALDHALF HGPPGLGKTT LANILANELE VGIKITSGPV LDKPGDLAGL
110 120 130 140 150
LTNLDERDVL FIDEIHRLSP IVEEYLYSAM EDFKIDIMIE SGPNARTVQI
160 170 180 190 200
NLNPFTLIGA TTRSGLLTAP MRARFGISSR LQYYSTELLT TIVERSAGIL
210 220 230 240 250
KMPIDLEAAI EIAGRSRGTP RIANALLRRV RDFAQIKGNG TIDLEISKYA
260 270 280 290 300
LKALNVDAHG LDEMDNKILL TIINKFKGGP VGLSTLATAV SESSETIEEV
310 320 330 340
YEPFLIQEGF IMRTPRGREV TEKAYKHLGK INTNIQGGLF
Length:340
Mass (Da):37,438
Last modified:June 12, 2007 - v1
Checksum:i621B9E4E06A79C96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000685 Genomic DNA Translation: ABQ04674.1
RefSeqiWP_012023718.1, NZ_MUGZ01000017.1

Genome annotation databases

EnsemblBacteriaiABQ04674; ABQ04674; Fjoh_1642
GeneIDi31764523
KEGGifjo:Fjoh_1642

Similar proteinsi

Entry informationi

Entry nameiRUVB_FLAJ1
AccessioniPrimary (citable) accession number: A5FJE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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