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A5FJ95

- PDXJ_FLAJ1

UniProt

A5FJ95 - PDXJ_FLAJ1

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Protein

Pyridoxine 5'-phosphate synthase

Gene

pdxJ

Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.UniRule annotation

Catalytic activityi

1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 713-amino-2-oxopropyl phosphateUniRule annotation
Binding sitei18 – 1813-amino-2-oxopropyl phosphateUniRule annotation
Active sitei43 – 431Proton acceptorUniRule annotation
Binding sitei45 – 4511-deoxy-D-xylulose 5-phosphateUniRule annotation
Binding sitei50 – 5011-deoxy-D-xylulose 5-phosphateUniRule annotation
Active sitei70 – 701Proton acceptorUniRule annotation
Binding sitei100 – 10011-deoxy-D-xylulose 5-phosphateUniRule annotation
Sitei151 – 1511Transition state stabilizerUniRule annotation
Active sitei190 – 1901Proton donorUniRule annotation
Binding sitei191 – 19113-amino-2-oxopropyl phosphate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyridoxine biosynthesis

Enzyme and pathway databases

BioCyciFJOH376686:GIXN-1728-MONOMER.
UniPathwayiUPA00244; UER00313.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxine 5'-phosphate synthaseUniRule annotation (EC:2.6.99.2UniRule annotation)
Short name:
PNP synthaseUniRule annotation
Gene namesi
Name:pdxJUniRule annotation
Ordered Locus Names:Fjoh_1695
OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Taxonomic identifieri376686 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
ProteomesiUP000006694: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Pyridoxine 5'-phosphate synthasePRO_1000078818Add
BLAST

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi376686.Fjoh_1695.

Structurei

3D structure databases

ProteinModelPortaliA5FJ95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni213 – 21423-amino-2-oxopropyl phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PNP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0854.
HOGENOMiHOG000258095.
KOiK03474.
OMAiVPETRQE.
OrthoDBiEOG6M9F0H.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00279. PdxJ.
InterProiIPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view]
PfamiPF03740. PdxJ. 1 hit.
[Graphical view]
SUPFAMiSSF63892. SSF63892. 1 hit.
TIGRFAMsiTIGR00559. pdxJ. 1 hit.

Sequencei

Sequence statusi: Complete.

A5FJ95-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKLSVNINK IATLRNARGG NVPDLLKVAA DIQRFGGQGI TIHPRPDERH
60 70 80 90 100
IRYQDARDLK AIVTTEYNIE GNPQHNFIDL VLECKPDQVT LVPDAIGAIT
110 120 130 140 150
SSAGWDTIKN QEYLKEVIQE FQRNGIRTSI FVDPVLEMIE GAKKTGTDRI
160 170 180 190 200
ELYTEAFAHQ YDLGNKNGID PYVKAAELAN ELGLGINAGH DLSLDNIQFF
210 220 230
KQNIPGLLEV SIGHALISEA LYLGLDNVVN MYLKKLK
Length:237
Mass (Da):26,351
Last modified:June 12, 2007 - v1
Checksum:iC7A6869CEF1EC6F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000685 Genomic DNA. Translation: ABQ04727.1.
RefSeqiWP_012023771.1. NC_009441.1.
YP_001194046.1. NC_009441.1.

Genome annotation databases

EnsemblBacteriaiABQ04727; ABQ04727; Fjoh_1695.
GeneIDi5091154.
KEGGifjo:Fjoh_1695.
PATRICi21897737. VBIFlaJoh53613_1742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000685 Genomic DNA. Translation: ABQ04727.1 .
RefSeqi WP_012023771.1. NC_009441.1.
YP_001194046.1. NC_009441.1.

3D structure databases

ProteinModelPortali A5FJ95.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 376686.Fjoh_1695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ04727 ; ABQ04727 ; Fjoh_1695 .
GeneIDi 5091154.
KEGGi fjo:Fjoh_1695.
PATRICi 21897737. VBIFlaJoh53613_1742.

Phylogenomic databases

eggNOGi COG0854.
HOGENOMi HOG000258095.
KOi K03474.
OMAi VPETRQE.
OrthoDBi EOG6M9F0H.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00313 .
BioCyci FJOH376686:GIXN-1728-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00279. PdxJ.
InterProi IPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view ]
Pfami PF03740. PdxJ. 1 hit.
[Graphical view ]
SUPFAMi SSF63892. SSF63892. 1 hit.
TIGRFAMsi TIGR00559. pdxJ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Novel features of the polysaccharide-digesting gliding bacterium Flavobacterium johnsoniae as revealed by genome sequence analysis."
    McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G., Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R., Cheng Y.Q., Stein J.L.
    Appl. Environ. Microbiol. 75:6864-6875(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17061 / DSM 2064 / UW101.

Entry informationi

Entry nameiPDXJ_FLAJ1
AccessioniPrimary (citable) accession number: A5FJ95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3