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A5FJ95

- PDXJ_FLAJ1

UniProt

A5FJ95 - PDXJ_FLAJ1

Protein

Pyridoxine 5'-phosphate synthase

Gene

pdxJ

Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.UniRule annotation

    Catalytic activityi

    1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei7 – 713-amino-2-oxopropyl phosphateUniRule annotation
    Binding sitei18 – 1813-amino-2-oxopropyl phosphateUniRule annotation
    Active sitei43 – 431Proton acceptorUniRule annotation
    Binding sitei45 – 4511-deoxy-D-xylulose 5-phosphateUniRule annotation
    Binding sitei50 – 5011-deoxy-D-xylulose 5-phosphateUniRule annotation
    Active sitei70 – 701Proton acceptorUniRule annotation
    Binding sitei100 – 10011-deoxy-D-xylulose 5-phosphateUniRule annotation
    Sitei151 – 1511Transition state stabilizerUniRule annotation
    Active sitei190 – 1901Proton donorUniRule annotation
    Binding sitei191 – 19113-amino-2-oxopropyl phosphate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Enzyme and pathway databases

    BioCyciFJOH376686:GIXN-1728-MONOMER.
    UniPathwayiUPA00244; UER00313.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyridoxine 5'-phosphate synthaseUniRule annotation (EC:2.6.99.2UniRule annotation)
    Short name:
    PNP synthaseUniRule annotation
    Gene namesi
    Name:pdxJUniRule annotation
    Ordered Locus Names:Fjoh_1695
    OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
    Taxonomic identifieri376686 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
    ProteomesiUP000006694: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 237237Pyridoxine 5'-phosphate synthasePRO_1000078818Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer; tetramer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi376686.Fjoh_1695.

    Structurei

    3D structure databases

    ProteinModelPortaliA5FJ95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni213 – 21423-amino-2-oxopropyl phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0854.
    HOGENOMiHOG000258095.
    KOiK03474.
    OMAiVPETRQE.
    OrthoDBiEOG6M9F0H.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00279. PdxJ.
    InterProiIPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view]
    PfamiPF03740. PdxJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF63892. SSF63892. 1 hit.
    TIGRFAMsiTIGR00559. pdxJ. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5FJ95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKLSVNINK IATLRNARGG NVPDLLKVAA DIQRFGGQGI TIHPRPDERH    50
    IRYQDARDLK AIVTTEYNIE GNPQHNFIDL VLECKPDQVT LVPDAIGAIT 100
    SSAGWDTIKN QEYLKEVIQE FQRNGIRTSI FVDPVLEMIE GAKKTGTDRI 150
    ELYTEAFAHQ YDLGNKNGID PYVKAAELAN ELGLGINAGH DLSLDNIQFF 200
    KQNIPGLLEV SIGHALISEA LYLGLDNVVN MYLKKLK 237
    Length:237
    Mass (Da):26,351
    Last modified:June 12, 2007 - v1
    Checksum:iC7A6869CEF1EC6F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000685 Genomic DNA. Translation: ABQ04727.1.
    RefSeqiYP_001194046.1. NC_009441.1.

    Genome annotation databases

    EnsemblBacteriaiABQ04727; ABQ04727; Fjoh_1695.
    GeneIDi5091154.
    KEGGifjo:Fjoh_1695.
    PATRICi21897737. VBIFlaJoh53613_1742.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000685 Genomic DNA. Translation: ABQ04727.1 .
    RefSeqi YP_001194046.1. NC_009441.1.

    3D structure databases

    ProteinModelPortali A5FJ95.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 376686.Fjoh_1695.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ04727 ; ABQ04727 ; Fjoh_1695 .
    GeneIDi 5091154.
    KEGGi fjo:Fjoh_1695.
    PATRICi 21897737. VBIFlaJoh53613_1742.

    Phylogenomic databases

    eggNOGi COG0854.
    HOGENOMi HOG000258095.
    KOi K03474.
    OMAi VPETRQE.
    OrthoDBi EOG6M9F0H.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00313 .
    BioCyci FJOH376686:GIXN-1728-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00279. PdxJ.
    InterProi IPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view ]
    Pfami PF03740. PdxJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63892. SSF63892. 1 hit.
    TIGRFAMsi TIGR00559. pdxJ. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Novel features of the polysaccharide-digesting gliding bacterium Flavobacterium johnsoniae as revealed by genome sequence analysis."
      McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G., Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R., Cheng Y.Q., Stein J.L.
      Appl. Environ. Microbiol. 75:6864-6875(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17061 / DSM 2064 / UW101.

    Entry informationi

    Entry nameiPDXJ_FLAJ1
    AccessioniPrimary (citable) accession number: A5FJ95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3