SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A5FJ95

- PDXJ_FLAJ1

UniProt

A5FJ95 - PDXJ_FLAJ1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Pyridoxine 5'-phosphate synthase

Gene
pdxJ, Fjoh_1695
Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate By similarity.UniRule annotation

Catalytic activityi

1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 713-amino-2-oxopropyl phosphate By similarity
Binding sitei18 – 1813-amino-2-oxopropyl phosphate By similarity
Active sitei43 – 431Proton acceptor By similarity
Binding sitei45 – 4511-deoxy-D-xylulose 5-phosphate By similarity
Binding sitei50 – 5011-deoxy-D-xylulose 5-phosphate By similarity
Active sitei70 – 701Proton acceptor By similarity
Binding sitei100 – 10011-deoxy-D-xylulose 5-phosphate By similarity
Sitei151 – 1511Transition state stabilizer By similarity
Active sitei190 – 1901Proton donor By similarity
Binding sitei191 – 19113-amino-2-oxopropyl phosphate; via amide nitrogen By similarity

GO - Molecular functioni

  1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyridoxine biosynthesis

Enzyme and pathway databases

BioCyciFJOH376686:GIXN-1728-MONOMER.
UniPathwayiUPA00244; UER00313.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxine 5'-phosphate synthase (EC:2.6.99.2)
Short name:
PNP synthase
Gene namesi
Name:pdxJ
Ordered Locus Names:Fjoh_1695
OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Taxonomic identifieri376686 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
ProteomesiUP000006694: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Pyridoxine 5'-phosphate synthaseUniRule annotationPRO_1000078818Add
BLAST

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi376686.Fjoh_1695.

Structurei

3D structure databases

ProteinModelPortaliA5FJ95.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni213 – 21423-amino-2-oxopropyl phosphate binding By similarity

Sequence similaritiesi

Belongs to the PNP synthase family.

Phylogenomic databases

eggNOGiCOG0854.
HOGENOMiHOG000258095.
KOiK03474.
OMAiVPETRQE.
OrthoDBiEOG6M9F0H.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00279. PdxJ.
InterProiIPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view]
PfamiPF03740. PdxJ. 1 hit.
[Graphical view]
SUPFAMiSSF63892. SSF63892. 1 hit.
TIGRFAMsiTIGR00559. pdxJ. 1 hit.

Sequencei

Sequence statusi: Complete.

A5FJ95-1 [UniParc]FASTAAdd to Basket

« Hide

MTKLSVNINK IATLRNARGG NVPDLLKVAA DIQRFGGQGI TIHPRPDERH    50
IRYQDARDLK AIVTTEYNIE GNPQHNFIDL VLECKPDQVT LVPDAIGAIT 100
SSAGWDTIKN QEYLKEVIQE FQRNGIRTSI FVDPVLEMIE GAKKTGTDRI 150
ELYTEAFAHQ YDLGNKNGID PYVKAAELAN ELGLGINAGH DLSLDNIQFF 200
KQNIPGLLEV SIGHALISEA LYLGLDNVVN MYLKKLK 237
Length:237
Mass (Da):26,351
Last modified:June 12, 2007 - v1
Checksum:iC7A6869CEF1EC6F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000685 Genomic DNA. Translation: ABQ04727.1.
RefSeqiYP_001194046.1. NC_009441.1.

Genome annotation databases

EnsemblBacteriaiABQ04727; ABQ04727; Fjoh_1695.
GeneIDi5091154.
KEGGifjo:Fjoh_1695.
PATRICi21897737. VBIFlaJoh53613_1742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000685 Genomic DNA. Translation: ABQ04727.1 .
RefSeqi YP_001194046.1. NC_009441.1.

3D structure databases

ProteinModelPortali A5FJ95.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 376686.Fjoh_1695.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ04727 ; ABQ04727 ; Fjoh_1695 .
GeneIDi 5091154.
KEGGi fjo:Fjoh_1695.
PATRICi 21897737. VBIFlaJoh53613_1742.

Phylogenomic databases

eggNOGi COG0854.
HOGENOMi HOG000258095.
KOi K03474.
OMAi VPETRQE.
OrthoDBi EOG6M9F0H.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00313 .
BioCyci FJOH376686:GIXN-1728-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00279. PdxJ.
InterProi IPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view ]
Pfami PF03740. PdxJ. 1 hit.
[Graphical view ]
SUPFAMi SSF63892. SSF63892. 1 hit.
TIGRFAMsi TIGR00559. pdxJ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Novel features of the polysaccharide-digesting gliding bacterium Flavobacterium johnsoniae as revealed by genome sequence analysis."
    McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G., Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R., Cheng Y.Q., Stein J.L.
    Appl. Environ. Microbiol. 75:6864-6875(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17061 / DSM 2064 / UW101.

Entry informationi

Entry nameiPDXJ_FLAJ1
AccessioniPrimary (citable) accession number: A5FJ95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi