Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Malate dehydrogenase

Gene

mdh

Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32NAD1
Binding sitei82Substrate1
Binding sitei88Substrate1
Binding sitei95NAD1
Binding sitei120Substrate1
Binding sitei151Substrate1
Active sitei175Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 12NAD6
Nucleotide bindingi118 – 120NAD3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:Fjoh_2255
OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Taxonomic identifieri376686 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
Proteomesi
  • UP000006694 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000813601 – 311Malate dehydrogenaseAdd BLAST311

Interactioni

Protein-protein interaction databases

STRINGi376686.Fjoh_2255.

Structurei

3D structure databases

ProteinModelPortaliA5FHP3.
SMRiA5FHP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiMDLMQTA.
OrthoDBiPOG091H02N6.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A5FHP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVTIVGAGN VGATCADVIS YRGIASEVVL LDIKEGFAEG KALDITQCAT
60 70 80 90 100
NTGFNTKVSG VTNDYSKTAG SDVVVITSGI PRKPGMTREE LIGINAGIVK
110 120 130 140 150
TVAENVLKYS PNTIIVVVSN PMDTMTYLAL KATGLPKNRI IGMGGALDSS
160 170 180 190 200
RFRTYLSLAL DKPANDISAM VIGGHGDTTM IPLTRLASYN GIPVSQFLSE
210 220 230 240 250
DVLQKVAADT MVGGATLTGL LGTSAWYAPG ASVAYLVDSI LNDQKKMIAC
260 270 280 290 300
SVFVEGEYGQ NDICIGVPCI IGKNGVEEIV NINLNDQEKA LFAKSADAVR
310
GMNDALKSIL V
Length:311
Mass (Da):32,562
Last modified:June 12, 2007 - v1
Checksum:iC227E247EEB41128
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000685 Genomic DNA. Translation: ABQ05283.1.
RefSeqiWP_012024322.1. NZ_MUGZ01000022.1.

Genome annotation databases

EnsemblBacteriaiABQ05283; ABQ05283; Fjoh_2255.
GeneIDi31765164.
KEGGifjo:Fjoh_2255.

Similar proteinsi

Entry informationi

Entry nameiMDH_FLAJ1
AccessioniPrimary (citable) accession number: A5FHP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: November 22, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families