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A5FH28

- SERC_FLAJ1

UniProt

A5FH28 - SERC_FLAJ1

Protein

Phosphoserine aminotransferase

Gene

serC

Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.UniRule annotation

    Catalytic activityi

    O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.UniRule annotation
    4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.UniRule annotation

    Cofactori

    Binds 1 pyridoxal phosphate per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411L-glutamateUniRule annotation
    Binding sitei102 – 1021Pyridoxal phosphateUniRule annotation
    Binding sitei150 – 1501Pyridoxal phosphateUniRule annotation
    Binding sitei169 – 1691Pyridoxal phosphateUniRule annotation
    Binding sitei192 – 1921Pyridoxal phosphateUniRule annotation

    GO - Molecular functioni

    1. O-phospho-L-serine:2-oxoglutarate aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-serine biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Pyridoxine biosynthesis, Serine biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciFJOH376686:GIXN-2519-MONOMER.
    UniPathwayiUPA00135; UER00197.
    UPA00244; UER00311.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoserine aminotransferaseUniRule annotation (EC:2.6.1.52UniRule annotation)
    Alternative name(s):
    Phosphohydroxythreonine aminotransferaseUniRule annotation
    Short name:
    PSATUniRule annotation
    Gene namesi
    Name:serCUniRule annotation
    Ordered Locus Names:Fjoh_2462
    OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
    Taxonomic identifieri376686 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
    ProteomesiUP000006694: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356Phosphoserine aminotransferasePRO_1000076906Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei193 – 1931N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi376686.Fjoh_2462.

    Structurei

    3D structure databases

    ProteinModelPortaliA5FH28.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni76 – 772Pyridoxal phosphate bindingUniRule annotation
    Regioni234 – 2352Pyridoxal phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1932.
    HOGENOMiHOG000088965.
    KOiK00831.
    OMAiFAAIPMN.
    OrthoDBiEOG60CWP3.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_00160. SerC_aminotrans_5.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR020578. Aminotrans_V_PyrdxlP_BS.
    IPR022278. Pser_aminoTfrase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00266. Aminotran_5. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000525. SerC. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    PROSITEiPS00595. AA_TRANSFER_CLASS_5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5FH28-1 [UniParc]FASTAAdd to Basket

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    MKKHNYSAGP SILPQEVFEK ASKAVLNFND SGLSILEISH RSKDFVAVMD    50
    EARSLALELL GLQGKGYQAL FLQGGASTAF LMAPYNLMKE NGKAAYLDSG 100
    TWATAAIKEA KLFGETVIVG SSKDDNYTYI PKGYEIPADA DYFHCTSNNT 150
    IFGTQIQEFP STNIPVVCDM SSDIFSRELD FSKFDLIYAG AQKNMGPAGT 200
    TLVVVKEEIL GKNGRTIPSM LDYAKHIKAE SMYNTPSVFA VYVSLLTLQW 250
    IKAKGGIAAV EKLNNAKADL LYAEIDRNPL FKGAANVEDR SKMNVTFLLN 300
    NPEHTETFDA LWKAAGISGL PGHRSVGGYR ASIYNAMPIE SVQVLVDVMK 350
    ALESKV 356
    Length:356
    Mass (Da):38,871
    Last modified:June 12, 2007 - v1
    Checksum:i001013680A26430E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000685 Genomic DNA. Translation: ABQ05489.1.
    RefSeqiYP_001194808.1. NC_009441.1.

    Genome annotation databases

    EnsemblBacteriaiABQ05489; ABQ05489; Fjoh_2462.
    GeneIDi5090319.
    KEGGifjo:Fjoh_2462.
    PATRICi21899361. VBIFlaJoh53613_2532.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000685 Genomic DNA. Translation: ABQ05489.1 .
    RefSeqi YP_001194808.1. NC_009441.1.

    3D structure databases

    ProteinModelPortali A5FH28.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 376686.Fjoh_2462.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ05489 ; ABQ05489 ; Fjoh_2462 .
    GeneIDi 5090319.
    KEGGi fjo:Fjoh_2462.
    PATRICi 21899361. VBIFlaJoh53613_2532.

    Phylogenomic databases

    eggNOGi COG1932.
    HOGENOMi HOG000088965.
    KOi K00831.
    OMAi FAAIPMN.
    OrthoDBi EOG60CWP3.

    Enzyme and pathway databases

    UniPathwayi UPA00135 ; UER00197 .
    UPA00244 ; UER00311 .
    BioCyci FJOH376686:GIXN-2519-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_00160. SerC_aminotrans_5.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR020578. Aminotrans_V_PyrdxlP_BS.
    IPR022278. Pser_aminoTfrase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00266. Aminotran_5. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000525. SerC. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    PROSITEi PS00595. AA_TRANSFER_CLASS_5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel features of the polysaccharide-digesting gliding bacterium Flavobacterium johnsoniae as revealed by genome sequence analysis."
      McBride M.J., Xie G., Martens E.C., Lapidus A., Henrissat B., Rhodes R.G., Goltsman E., Wang W., Xu J., Hunnicutt D.W., Staroscik A.M., Hoover T.R., Cheng Y.Q., Stein J.L.
      Appl. Environ. Microbiol. 75:6864-6875(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17061 / DSM 2064 / UW101.

    Entry informationi

    Entry nameiSERC_FLAJ1
    AccessioniPrimary (citable) accession number: A5FH28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3