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A5FFY3 (ILVC_FLAJ1) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:Fjoh_2860
OrganismFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae) [Complete proteome] [HAMAP]
Taxonomic identifier376686 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 489489Ketol-acid reductoisomerase HAMAP MF_00435
PRO_1000190965

Sites

Active site1321 Potential

Sequences

Sequence LengthMass (Da)Tools
A5FFY3 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 895BFE1CC5587D37

FASTA48954,050
        10         20         30         40         50         60 
MANYFNTLPL RLQLEQLGVC EFMEQSEFAD GISALAGKKV VIVGCGAQGL NQGLNMRDSG 

        70         80         90        100        110        120 
LDISYALRAD AIAEKRASYK NATENGFKVG TYEELIPTAD LVCNLTPDKQ HTSVVNAIMP 

       130        140        150        160        170        180 
LMKQGSTLAY SHGFNIVEEG MQIRKDITVI MCAPKCPGSE VREEYKRGFG VPTLIAVHPE 

       190        200        210        220        230        240 
NDPNGFGLDQ AKAYAVATGG HKAGVLRSSF VAEVKSDLMG EQTILCGLLQ TGSILCFDKM 

       250        260        270        280        290        300 
VEKGIDAAYA SKLIQYGWET ITEALKHGGI TNMMDRLNNP SKIEAYELAE ELKDIMRPLF 

       310        320        330        340        350        360 
QKHQDDIISG EFSRTMMIDW ANDDVNLLKW RAATGETNFE KTAPQEAPIS EQEYFDNGVL 

       370        380        390        400        410        420 
MIAMVKAGVE LAFETMTEAG IIEESAYYES LHELPLIANT IARKKLFEMN RVISDTAEYG 

       430        440        450        460        470        480 
CYLFDHACKP LLTEFMKKVE TNIIGKPFST SNGVDNTVLI AVNKEIRQHP IEEVGAWLRE 


SMTAMKKIG

« Hide

References

[1]"Complete sequence of Flavobacterium johnsoniae UW101."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E., Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Xie G., McBride M., Richardson P.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17061 / DSM 2064 / UW101.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000685 Genomic DNA. Translation: ABQ05881.1.
RefSeqYP_001195200.1. NC_009441.1.

3D structure databases

ProteinModelPortalA5FFY3.
SMRA5FFY3. Positions 3-489.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5FFY3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5090489.
GenomeReviewsGene locus Fjoh_2860 in contig CP000685_GR.
KEGGfjo:Fjoh_2860.
PATRIC21900227. VBIFlaJoh53613_2957.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHBG297205.
OMAEKHMDDI.
ProtClustDBPRK05225.

Enzyme and pathway databases

BioCycFJOH376686:FJOH_2860-MONOMER.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
IPR014359. KetolA_reductoisomerase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PTHR21371:SF2. PTHR21371:SF2. 1 hit.
PfamPF01450. IlvC. 2 hits.
PF07991. IlvN. 1 hit.
[Graphical view]
PIRSFPIRSF000116. IlvC_gammaproteo. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 2 hits.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_FLAJ1
AccessionPrimary (citable) accession number: A5FFY3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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