Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Catalase-peroxidase

Gene

katG

Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei97Transition state stabilizerUniRule annotation1
Active sitei101Proton acceptorUniRule annotation1
Metal bindingi288Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei3617. FjCP01_UW101.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Fjoh_3897
OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Taxonomic identifieri376686 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
Proteomesi
  • UP000006694 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547871 – 757Catalase-peroxidaseAdd BLAST757

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki100 ↔ 247Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-273)UniRule annotation
Cross-linki247 ↔ 273Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-100)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA5FD11.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi376686.Fjoh_3897.

Structurei

3D structure databases

ProteinModelPortaliA5FD11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5FD11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENQSNDISK CPFHNGSMDN QAASGTKNND WWPKQLKVNI LRQNSSLSNP
60 70 80 90 100
LSKDFDYAEA FKTLDLEAVK KDLHVLMTDS QDWWPADFGH YGGLFIRMAW
110 120 130 140 150
HSAGTYRVHD GRGGAGAGQQ RFAPLNSWPD NVSLDKARRL LWPIKQKYGQ
160 170 180 190 200
KISWADLMIL TGNVALESMG FKTFGFAGGR ADVWEPDESV YWGSETTWLG
210 220 230 240 250
GDERYNNGSD GVPKDHGVVS ADDDADGKVH SRNLEKPLAA VQMGLIYVNP
260 270 280 290 300
EGPDGNPDPI LAAKDIRDTF GRMAMNDEET VALIAGGHTF GKTHGAASSD
310 320 330 340 350
HVDKEPEAAG LELQGFGWKN SFGSGKGADA ITSGLEVTWT KTPTQWSNNF
360 370 380 390 400
FENLFAFEWE LSKSPAGAHQ WVAKNAEAII PDAFDSTKKH LPTMLTTDLS
410 420 430 440 450
LRLDPEYEKI SRRFLENPDQ FADAFSRAWF KLTHRDMGPR ARYLGPDVPQ
460 470 480 490 500
EVLLWQDPIP EVNHKLIDEN DIKQLKEKIL NSGLSISQLV AAAWASASTF
510 520 530 540 550
RGSDKRGGAN GARVRLAPQK DWEVNNPAKL AQVLSKLETI QTEFNASQND
560 570 580 590 600
GKKVSLADLI VLAGSAGVEK AAKDAGSSVT VSFNPGRMDA SAEETDVESF
610 620 630 640 650
GYLEPKADGF RNYRKTKSAV STEELLIDKA NLLTLTAPEL TVLLGGLRVL
660 670 680 690 700
DINADGSKNG VFTHRPGQLT NDFFVNLLDM NTQWQAVSND KELYAGNDRS
710 720 730 740 750
TGQPKWIATR ADLVFGSNSE LRAVAEVYAS TDANEKFVND FIKAWTKVMN

LDRFDLA
Length:757
Mass (Da):83,445
Last modified:June 12, 2007 - v1
Checksum:i9BC9972154BAE01B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000685 Genomic DNA. Translation: ABQ06908.1.
RefSeqiWP_012025874.1. NC_009441.1.

Genome annotation databases

EnsemblBacteriaiABQ06908; ABQ06908; Fjoh_3897.
KEGGifjo:Fjoh_3897.
PATRICi21902389. VBIFlaJoh53613_4037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000685 Genomic DNA. Translation: ABQ06908.1.
RefSeqiWP_012025874.1. NC_009441.1.

3D structure databases

ProteinModelPortaliA5FD11.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi376686.Fjoh_3897.

Protein family/group databases

PeroxiBasei3617. FjCP01_UW101.

Proteomic databases

PRIDEiA5FD11.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ06908; ABQ06908; Fjoh_3897.
KEGGifjo:Fjoh_3897.
PATRICi21902389. VBIFlaJoh53613_4037.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_FLAJ1
AccessioniPrimary (citable) accession number: A5FD11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: June 12, 2007
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.