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Protein

Dihydrolipoyl dehydrogenase

Gene

Fjoh_4676

Organism
Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

BioCyciFJOH376686:GIXN-4714-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Ordered Locus Names:Fjoh_4676Imported
OrganismiFlavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) (Cytophaga johnsonae)Imported
Taxonomic identifieri376686 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
Proteomesi
  • UP000006694 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi376686.Fjoh_4676.

Structurei

3D structure databases

ProteinModelPortaliA5FAU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 323FAD/NAD-binding_domInterPro annotationAdd BLAST321
Domaini343 – 451Pyr_redox_dimInterPro annotationAdd BLAST109

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiHAINKHN.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5FAU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDVIVLGS GPGGYVTAIR ASQLGFKVAV VEKENLGGVC LNWGCIPTKA
60 70 80 90 100
LLKSAQVFDY LKHASDYGLK VSEFDKDFPA VIQRSRGVAE GMSKGVQFLM
110 120 130 140 150
KKNKIDVIEG FGKLKPGKKL DVTDKDNKVT EYSADHIIIA TGARSRELPN
160 170 180 190 200
LPQDGVKVIG YRQAMTLPTQ PKSMIIVGSG AIGVEFAHFY NSMGTDVTIV
210 220 230 240 250
EFMPNIVPVE DEDVSKQMER SMKKAGVKIM TNSSVEKIDT TGNGVKATVK
260 270 280 290 300
TAKGEEILEA DIVLSAVGIK TNIENIGLEE VGIAVDRDKI LVNAYNETNI
310 320 330 340 350
PGYYAIGDVT PGQALAHVAS AEGINCVEKI KGLHVDPIDY GNIPGCTYAT
360 370 380 390 400
PEIASVGLTE KQARDKGYEL KIGKFPFSAS GKAKAAGAAD GFVKVIFDAK
410 420 430 440 450
YGEWLGCHMI GAGVTDMIAE AVVARKLETT GHEVLKSIHP HPTMSEAVME
460
AVADAYGEVI HL
Length:462
Mass (Da):49,483
Last modified:June 12, 2007 - v1
Checksum:i9E12E3D7991AA746
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000685 Genomic DNA. Translation: ABQ07675.1.
RefSeqiWP_012026641.1. NC_009441.1.

Genome annotation databases

EnsemblBacteriaiABQ07675; ABQ07675; Fjoh_4676.
KEGGifjo:Fjoh_4676.
PATRICi21904005. VBIFlaJoh53613_4837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000685 Genomic DNA. Translation: ABQ07675.1.
RefSeqiWP_012026641.1. NC_009441.1.

3D structure databases

ProteinModelPortaliA5FAU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi376686.Fjoh_4676.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ07675; ABQ07675; Fjoh_4676.
KEGGifjo:Fjoh_4676.
PATRICi21904005. VBIFlaJoh53613_4837.

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiHAINKHN.
OrthoDBiPOG091H0239.

Enzyme and pathway databases

BioCyciFJOH376686:GIXN-4714-MONOMER.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA5FAU2_FLAJ1
AccessioniPrimary (citable) accession number: A5FAU2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.