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Protein

Glutaminase

Gene

glsA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641SubstrateUniRule annotation
Binding sitei115 – 1151SubstrateUniRule annotation
Binding sitei159 – 1591SubstrateUniRule annotation
Binding sitei166 – 1661SubstrateUniRule annotation
Binding sitei190 – 1901SubstrateUniRule annotation
Binding sitei242 – 2421SubstrateUniRule annotation
Binding sitei260 – 2601Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:VC0395_A0006, VC395_0498
OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Taxonomic identifieri345073 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000249: Chromosome 2, UP000001630: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306GlutaminasePRO_0000336042Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi345073.VC0395_A0006.

Structurei

3D structure databases

ProteinModelPortaliA5F9H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

A5F9H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPTAEILAS IIEEVRPLTG QGKVADYIPA LAKVPSEKLG IAVFTNQGEV
60 70 80 90 100
ISAGDAQEGF SIQSISKVLS LTLAMGLYQP NELWSRVGKE PSGQAFNSLI
110 120 130 140 150
QLEMEHGIPR NPFINAGAIV VCDMLQSRLS APRQRLLEFV RQLSGEPLIA
160 170 180 190 200
YDKVVAASEM MHSDRNAAIA YLMRSFGNFH NEVIPVLHNY FHACALKMSC
210 220 230 240 250
VELAKTFSYL ANKGVSVVTG ETVITPTQSK QTNALLATCG LYDGAGEFAY
260 270 280 290 300
RVGMPGKSGV GGGIIAVVPG EMTIAVWSPA LDQSGNSLAG TRALELLAQR

IGRSIF
Length:306
Mass (Da):32,757
Last modified:May 20, 2008 - v2
Checksum:i88E3BA76C39D862B
GO

Sequence cautioni

The sequence ABQ21307.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence ACP08517.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000627 Genomic DNA. Translation: ABQ21307.1. Different initiation.
CP001235 Genomic DNA. Translation: ACP08517.1. Different initiation.
RefSeqiYP_001215980.1. NC_009457.1.
YP_002818753.1. NC_012582.1.

Genome annotation databases

EnsemblBacteriaiABQ21307; ABQ21307; VC0395_A0006.
ACP08517; ACP08517; VC395_0498.
GeneIDi5135426.
7774545.
KEGGivco:VC0395_A0006.
vcr:VC395_0498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000627 Genomic DNA. Translation: ABQ21307.1. Different initiation.
CP001235 Genomic DNA. Translation: ACP08517.1. Different initiation.
RefSeqiYP_001215980.1. NC_009457.1.
YP_002818753.1. NC_012582.1.

3D structure databases

ProteinModelPortaliA5F9H5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi345073.VC0395_A0006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ21307; ABQ21307; VC0395_A0006.
ACP08517; ACP08517; VC395_0498.
GeneIDi5135426.
7774545.
KEGGivco:VC0395_A0006.
vcr:VC395_0498.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Heidelberg J.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395.
  2. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395.

Entry informationi

Entry nameiGLSA_VIBC3
AccessioniPrimary (citable) accession number: A5F9H5
Secondary accession number(s): C3M4P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: January 7, 2015
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.