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A5F9H5 (GLSA_VIBC3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutaminase
EC=3.5.1.2
Gene names
Name:glsA
Ordered Locus Names:VC0395_A0006, VC395_0498
OrganismVibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) [Complete proteome] [HAMAP]
Taxonomic identifier345073 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio ›

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the glutaminase family.

Sequence caution

The sequence ABQ21307.1 differs from that shown. Reason: Erroneous initiation.

The sequence ACP08517.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutaminase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Glutaminase HAMAP-Rule MF_00313
PRO_0000336042

Sites

Binding site641Substrate By similarity
Binding site1151Substrate By similarity
Binding site1591Substrate By similarity
Binding site1661Substrate By similarity
Binding site1901Substrate By similarity
Binding site2421Substrate By similarity
Binding site2601Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A5F9H5 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: 88E3BA76C39D862B

FASTA30632,757
        10         20         30         40         50         60 
MKPTAEILAS IIEEVRPLTG QGKVADYIPA LAKVPSEKLG IAVFTNQGEV ISAGDAQEGF 

        70         80         90        100        110        120 
SIQSISKVLS LTLAMGLYQP NELWSRVGKE PSGQAFNSLI QLEMEHGIPR NPFINAGAIV 

       130        140        150        160        170        180 
VCDMLQSRLS APRQRLLEFV RQLSGEPLIA YDKVVAASEM MHSDRNAAIA YLMRSFGNFH 

       190        200        210        220        230        240 
NEVIPVLHNY FHACALKMSC VELAKTFSYL ANKGVSVVTG ETVITPTQSK QTNALLATCG 

       250        260        270        280        290        300 
LYDGAGEFAY RVGMPGKSGV GGGIIAVVPG EMTIAVWSPA LDQSGNSLAG TRALELLAQR 


IGRSIF

« Hide

References

[1]Heidelberg J.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39541 / Ogawa 395 / O395.
[2]"A recalibrated molecular clock and independent origins for the cholera pandemic clones."
Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39541 / Ogawa 395 / O395.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000627 Genomic DNA. Translation: ABQ21307.1. Different initiation.
CP001235 Genomic DNA. Translation: ACP08517.1. Different initiation.
RefSeqYP_001215980.1. NC_009457.1.
YP_002818753.1. NC_012582.1.

3D structure databases

ProteinModelPortalA5F9H5.
ModBaseSearch...

Protein-protein interaction databases

STRING345073.VC0395_A0006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ21307; ABQ21307; VC0395_A0006.
ACP08517; ACP08517; VC395_0498.
GeneID5135426.
7774545.
KEGGvco:VC0395_A0006.
vcr:VC395_0498.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2066.
HOGENOMHOG000216890.
KOK01425.
ProtClustDBPRK00971.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
HAMAPMF_00313. Glutaminase.
InterProIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERPTHR12544. PTHR12544. 1 hit.
PfamPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMSSF56601. PBP_transp_fold. 1 hit.
TIGRFAMsTIGR03814. Gln_ase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLSA_VIBC3
AccessionPrimary (citable) accession number: A5F9H5
Secondary accession number(s): C3M4P5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 1, 2013
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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