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A5F9H5

- GLSA_VIBC3

UniProt

A5F9H5 - GLSA_VIBC3

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Protein
Glutaminase
Gene
glsA, VC0395_A0006, VC395_0498
Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641Substrate By similarity
Binding sitei115 – 1151Substrate By similarity
Binding sitei159 – 1591Substrate By similarity
Binding sitei166 – 1661Substrate By similarity
Binding sitei190 – 1901Substrate By similarity
Binding sitei242 – 2421Substrate By similarity
Binding sitei260 – 2601Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:VC0395_A0006, VC395_0498
OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Taxonomic identifieri345073 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000249: Chromosome 2, UP000001630: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306GlutaminaseUniRule annotation
PRO_0000336042Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi345073.VC0395_A0006.

Structurei

3D structure databases

ProteinModelPortaliA5F9H5.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

A5F9H5-1 [UniParc]FASTAAdd to Basket

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MKPTAEILAS IIEEVRPLTG QGKVADYIPA LAKVPSEKLG IAVFTNQGEV    50
ISAGDAQEGF SIQSISKVLS LTLAMGLYQP NELWSRVGKE PSGQAFNSLI 100
QLEMEHGIPR NPFINAGAIV VCDMLQSRLS APRQRLLEFV RQLSGEPLIA 150
YDKVVAASEM MHSDRNAAIA YLMRSFGNFH NEVIPVLHNY FHACALKMSC 200
VELAKTFSYL ANKGVSVVTG ETVITPTQSK QTNALLATCG LYDGAGEFAY 250
RVGMPGKSGV GGGIIAVVPG EMTIAVWSPA LDQSGNSLAG TRALELLAQR 300
IGRSIF 306
Length:306
Mass (Da):32,757
Last modified:May 20, 2008 - v2
Checksum:i88E3BA76C39D862B
GO

Sequence cautioni

The sequence ABQ21307.1 differs from that shown. Reason: Erroneous initiation.
The sequence ACP08517.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000627 Genomic DNA. Translation: ABQ21307.1. Different initiation.
CP001235 Genomic DNA. Translation: ACP08517.1. Different initiation.
RefSeqiYP_001215980.1. NC_009457.1.
YP_002818753.1. NC_012582.1.

Genome annotation databases

EnsemblBacteriaiABQ21307; ABQ21307; VC0395_A0006.
ACP08517; ACP08517; VC395_0498.
GeneIDi5135426.
7774545.
KEGGivco:VC0395_A0006.
vcr:VC395_0498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000627 Genomic DNA. Translation: ABQ21307.1 . Different initiation.
CP001235 Genomic DNA. Translation: ACP08517.1 . Different initiation.
RefSeqi YP_001215980.1. NC_009457.1.
YP_002818753.1. NC_012582.1.

3D structure databases

ProteinModelPortali A5F9H5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 345073.VC0395_A0006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ21307 ; ABQ21307 ; VC0395_A0006 .
ACP08517 ; ACP08517 ; VC395_0498 .
GeneIDi 5135426.
7774545.
KEGGi vco:VC0395_A0006.
vcr:VC395_0498.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Heidelberg J.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395.
  2. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395.

Entry informationi

Entry nameiGLSA_VIBC3
AccessioniPrimary (citable) accession number: A5F9H5
Secondary accession number(s): C3M4P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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