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A5F9H5

- GLSA_VIBC3

UniProt

A5F9H5 - GLSA_VIBC3

Protein

Glutaminase

Gene

glsA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei64 – 641SubstrateUniRule annotation
    Binding sitei115 – 1151SubstrateUniRule annotation
    Binding sitei159 – 1591SubstrateUniRule annotation
    Binding sitei166 – 1661SubstrateUniRule annotation
    Binding sitei190 – 1901SubstrateUniRule annotation
    Binding sitei242 – 2421SubstrateUniRule annotation
    Binding sitei260 – 2601Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
    Gene namesi
    Name:glsAUniRule annotation
    Ordered Locus Names:VC0395_A0006, VC395_0498
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
    Taxonomic identifieri345073 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000249: Chromosome 2, UP000001630: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306GlutaminasePRO_0000336042Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi345073.VC0395_A0006.

    Structurei

    3D structure databases

    ProteinModelPortaliA5F9H5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5F9H5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPTAEILAS IIEEVRPLTG QGKVADYIPA LAKVPSEKLG IAVFTNQGEV    50
    ISAGDAQEGF SIQSISKVLS LTLAMGLYQP NELWSRVGKE PSGQAFNSLI 100
    QLEMEHGIPR NPFINAGAIV VCDMLQSRLS APRQRLLEFV RQLSGEPLIA 150
    YDKVVAASEM MHSDRNAAIA YLMRSFGNFH NEVIPVLHNY FHACALKMSC 200
    VELAKTFSYL ANKGVSVVTG ETVITPTQSK QTNALLATCG LYDGAGEFAY 250
    RVGMPGKSGV GGGIIAVVPG EMTIAVWSPA LDQSGNSLAG TRALELLAQR 300
    IGRSIF 306
    Length:306
    Mass (Da):32,757
    Last modified:May 20, 2008 - v2
    Checksum:i88E3BA76C39D862B
    GO

    Sequence cautioni

    The sequence ABQ21307.1 differs from that shown. Reason: Erroneous initiation.
    The sequence ACP08517.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000627 Genomic DNA. Translation: ABQ21307.1. Different initiation.
    CP001235 Genomic DNA. Translation: ACP08517.1. Different initiation.
    RefSeqiYP_001215980.1. NC_009457.1.
    YP_002818753.1. NC_012582.1.

    Genome annotation databases

    EnsemblBacteriaiABQ21307; ABQ21307; VC0395_A0006.
    ACP08517; ACP08517; VC395_0498.
    GeneIDi5135426.
    7774545.
    KEGGivco:VC0395_A0006.
    vcr:VC395_0498.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000627 Genomic DNA. Translation: ABQ21307.1 . Different initiation.
    CP001235 Genomic DNA. Translation: ACP08517.1 . Different initiation.
    RefSeqi YP_001215980.1. NC_009457.1.
    YP_002818753.1. NC_012582.1.

    3D structure databases

    ProteinModelPortali A5F9H5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 345073.VC0395_A0006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ21307 ; ABQ21307 ; VC0395_A0006 .
    ACP08517 ; ACP08517 ; VC395_0498 .
    GeneIDi 5135426.
    7774545.
    KEGGi vco:VC0395_A0006.
    vcr:VC395_0498.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Heidelberg J.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39541 / Classical Ogawa 395 / O395.
    2. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
      Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
      PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39541 / Classical Ogawa 395 / O395.

    Entry informationi

    Entry nameiGLSA_VIBC3
    AccessioniPrimary (citable) accession number: A5F9H5
    Secondary accession number(s): C3M4P5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3