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A5F9G2

- PGK_VIBC3

UniProt

A5F9G2 - PGK_VIBC3

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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateBy similarity
Binding sitei113 – 1131SubstrateBy similarity
Binding sitei146 – 1461SubstrateBy similarity
Binding sitei197 – 1971ATPBy similarity
Binding sitei314 – 3141ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi340 – 3434ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:VC0395_A0030, VC395_0521
OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Taxonomic identifieri345073 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000249: Chromosome 2, UP000001630: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Phosphoglycerate kinasePRO_0000324783Add
BLAST

Proteomic databases

PRIDEiA5F9G2.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi345073.VC0395_A0030.

Structurei

3D structure databases

ProteinModelPortaliA5F9G2.
SMRiA5F9G2. Positions 2-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate bindingBy similarity
Regioni59 – 624Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5F9G2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVIKMIDLD LAGKRVFIRA DLNVPVKDGK VTSDARILAS LPTIKHCLEA
60 70 80 90 100
GAKVMVTSHL GRPTEGEYAE EFSLLPVVNY LNDALDCEVR LVKDYLDGVE
110 120 130 140 150
LNAGELVVLE NVRFNKGEKK NEEALSKKYA ALCDVFVMDA FGTAHRAQAS
160 170 180 190 200
THGVGMFAPI ACAGPLLADE LEALGKAMDK PARPMVAIVG GSKVSTKLTV
210 220 230 240 250
LESLSKIADQ LVVGGGIANT FIAAAGHNVG KSLYEADLVE TAKKLMEECA
260 270 280 290 300
IPVATDVACA KAFDENAEAE IKHVSEVQDD DMIFDLGPNS TAELAEILKN
310 320 330 340 350
AKTILWNGPV GVFEFKNFEA GTRGIAEAIA QSEGFSVAGG GDTLAAIDKF
360 370 380
GIKADVSYIS TGGGAFLEFV EGKKLPAVEM LEARAKA
Length:387
Mass (Da):40,979
Last modified:March 18, 2008 - v2
Checksum:i0D7EBFBF5C93F719
GO

Sequence cautioni

The sequence ABQ19963.1 differs from that shown. Reason: Erroneous initiation.
The sequence ACP08540.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000627 Genomic DNA. Translation: ABQ19963.1. Different initiation.
CP001235 Genomic DNA. Translation: ACP08540.1. Different initiation.
U72152 Genomic DNA. Translation: AAC44768.1.
RefSeqiYP_001216004.1. NC_009457.1.
YP_002818776.1. NC_012582.1.

Genome annotation databases

EnsemblBacteriaiABQ19963; ABQ19963; VC0395_A0030.
ACP08540; ACP08540; VC395_0521.
GeneIDi5136389.
7774564.
KEGGivco:VC0395_A0030.
vcr:VC395_0521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000627 Genomic DNA. Translation: ABQ19963.1 . Different initiation.
CP001235 Genomic DNA. Translation: ACP08540.1 . Different initiation.
U72152 Genomic DNA. Translation: AAC44768.1 .
RefSeqi YP_001216004.1. NC_009457.1.
YP_002818776.1. NC_012582.1.

3D structure databases

ProteinModelPortali A5F9G2.
SMRi A5F9G2. Positions 2-386.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 345073.VC0395_A0030.

Proteomic databases

PRIDEi A5F9G2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ19963 ; ABQ19963 ; VC0395_A0030 .
ACP08540 ; ACP08540 ; VC395_0521 .
GeneIDi 5136389.
7774564.
KEGGi vco:VC0395_A0030.
vcr:VC395_0521.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227107.
KOi K00927.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Heidelberg J.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395.
  2. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395.
  3. "Identification, sequencing, and enzymatic activity of the erythrose-4-phosphate dehydrogenase gene of Vibrio cholerae."
    Carroll P.A., Zhao G., Boyko S.A., Winkler M.E., Calderwood S.B.
    J. Bacteriol. 179:293-296(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16.

Entry informationi

Entry nameiPGK_VIBC3
AccessioniPrimary (citable) accession number: A5F9G2
Secondary accession number(s): C3LX30, P96154, Q9KUN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: October 29, 2014
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3