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A5F8K5

- A5F8K5_VIBC3

UniProt

A5F8K5 - A5F8K5_VIBC3

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Protein

Alanine racemase

Gene

VC0395_A0930

Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei95 – 951Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei194 – 1941SubstrateUniRule annotation
Active sitei320 – 3201Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei368 – 3681Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:VC0395_A0930Imported, VC395_1431Imported
OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)Imported
Taxonomic identifieri345073 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001630: Chromosome I, UP000000249: Chromosome 2

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei95 – 951N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi345073.VC0395_A0930.

Structurei

3D structure databases

ProteinModelPortaliA5F8K5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000279190.
KOiK01775.
OMAiQQIPCVA.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5F8K5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQPLLSRKK NVPSMITTGD IMHFKATLLS LSIAATLPSF SLSAAPLHID
60 70 80 90 100
TALPDAAQIQ QSNSWLEISL GQFQSNIEQF KSHMNANTKI CAIMKADAYG
110 120 130 140 150
NGIRGLMPTI IAQGIPCVGV ASNAEARAVR ESGFKGELIR VRSASLSEMS
160 170 180 190 200
SALDLNIEEL IGTHQQALDL AELAKQSGKT LKVHIALNDG GMGRNGIDMT
210 220 230 240 250
TEAGKKEAVS IATQPSLSVV GIMTHFPNYN ADEVRAKLAQ FKESSTWLMQ
260 270 280 290 300
QANLKREEIT LHVANSYTAL NVPEAQLDMV RPGGVLFGDL PTNPEYPSIV
310 320 330 340 350
SFKTRVSSLH HLPKDSTVGY DSTFTTSRDS VLANLPVGYS DGYPRKMGNK
360 370 380 390 400
AEVLINGQRA KVVGVTSMNT TVVDVTEIKG VLPGQEVVLF GQQQKQSIAV
410 420
SEMENNAELI FPELYTLWGT SNPRFYVK
Length:428
Mass (Da):46,407
Last modified:June 12, 2007 - v1
Checksum:i2FD8D39D89537530
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000627 Genomic DNA. Translation: ABQ20402.1.
CP001235 Genomic DNA. Translation: ACP09439.1.
RefSeqiYP_001216876.1. NC_009457.1.
YP_002819675.1. NC_012582.1.

Genome annotation databases

EnsemblBacteriaiABQ20402; ABQ20402; VC0395_A0930.
ACP09439; ACP09439; VC395_1431.
GeneIDi5135487.
7775347.
KEGGivco:VC0395_A0930.
vcr:VC395_1431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000627 Genomic DNA. Translation: ABQ20402.1 .
CP001235 Genomic DNA. Translation: ACP09439.1 .
RefSeqi YP_001216876.1. NC_009457.1.
YP_002819675.1. NC_012582.1.

3D structure databases

ProteinModelPortali A5F8K5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 345073.VC0395_A0930.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ20402 ; ABQ20402 ; VC0395_A0930 .
ACP09439 ; ACP09439 ; VC395_1431 .
GeneIDi 5135487.
7775347.
KEGGi vco:VC0395_A0930.
vcr:VC395_1431.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000279190.
KOi K01775.
OMAi QQIPCVA.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Heidelberg J.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395Imported and O395Imported.
  2. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395 and O395Imported.

Entry informationi

Entry nameiA5F8K5_VIBC3
AccessioniPrimary (citable) accession number: A5F8K5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3