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A5F890 (FNR_VIBC3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fumarate and nitrate reduction regulatory protein
Gene names
Name:fnr
Ordered Locus Names:VC0395_A1045, VC395_1554
OrganismVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) [Complete proteome] [HAMAP]
Taxonomic identifier345073 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O2, is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration By similarity.

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Fumarate and nitrate reduction regulatory protein
PRO_0000321853

Regions

Domain164 – 23774HTH crp-type
DNA binding200 – 21920H-T-H motif Potential
Region23 – 3210Essential for the oxygen-regulated activity By similarity
Region50 – 534Activating region 2A Potential
Region63 – 642Activating region 3A Potential
Region74 – 785Activating region 1A Potential
Region841Activating region 3B Potential
Region88 – 903Activating region 3C Potential
Region1151Activating region 3D Potential
Region119 – 1246Activating region 1B Potential
Region126 – 1272Activating region 2B Potential
Region130 – 1312Activating region 2C Potential
Region143 – 16220Dimerization Potential
Region184 – 19411Activating region 1C Potential

Sites

Metal binding201Iron-sulfur (4Fe-4S) Potential
Metal binding231Iron-sulfur (4Fe-4S) Potential
Metal binding291Iron-sulfur (4Fe-4S) Potential
Metal binding1221Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
A5F890 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: A3E3ED036BBBC490

FASTA25028,071
        10         20         30         40         50         60 
MISEKPAAKR IQSGGCAIHC QDCSISQLCI PFTLNESELD QLDQIIERKK PIQKGQELFK 

        70         80         90        100        110        120 
AGDELRSLYA IRSGTIKSYT ITEQGDEQIT AFHLAGDLVG FDAITGDQHP SFAQALETSM 

       130        140        150        160        170        180 
VCEIPYEILD DLSGKMPKLR QQIMRLMSNE IKGDQEMILL LSKKNAEERL AAFLYNLSTR 

       190        200        210        220        230        240 
FSQRGFSPRE FRLTMTRGDI GNYLGLTVET ISRLLGRFQK SEILSVKGKY ITILNHAELM 

       250 
ELAGVSKESK 

« Hide

References

« Hide 'large scale' references
[1]"The fnr gene of Vibrio cholerae."
Krishnan H.H., Chowdhury R.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Heidelberg J.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39541 / Classical Ogawa 395 / O395.
[3]"A recalibrated molecular clock and independent origins for the cholera pandemic clones."
Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39541 / Classical Ogawa 395 / O395.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF244992 Genomic DNA. Translation: AAG09773.1.
CP000627 Genomic DNA. Translation: ABQ20599.1.
CP001235 Genomic DNA. Translation: ACP09560.1.
RefSeqYP_001216991.1. NC_009457.1.
YP_002819796.1. NC_012582.1.

3D structure databases

ProteinModelPortalA5F890.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING345073.VC0395_A1045.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ20599; ABQ20599; VC0395_A1045.
ACP09560; ACP09560; VC395_1554.
GeneID5137220.
7775452.
KEGGvco:VC0395_A1045.
vcr:VC395_1554.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000186461.
KOK01420.
OMAFSANQFR.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSPR00034. HTHCRP.
SMARTSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFNR_VIBC3
AccessionPrimary (citable) accession number: A5F890
Secondary accession number(s): C3M0J4, Q9KS27
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families