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A5F890

- FNR_VIBC3

UniProt

A5F890 - FNR_VIBC3

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Protein
Fumarate and nitrate reduction regulatory protein
Gene
fnr, VC0395_A1045, VC395_1554
Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O2, is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration By similarity.

Cofactori

Binds 1 4Fe-4S cluster per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi20 – 201Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi23 – 231Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi29 – 291Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi122 – 1221Iron-sulfur (4Fe-4S) Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi200 – 21920H-T-H motif Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

4Fe-4S, DNA-binding, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate and nitrate reduction regulatory protein
Gene namesi
Name:fnr
Ordered Locus Names:VC0395_A1045, VC395_1554
OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Taxonomic identifieri345073 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000249: Chromosome 2, UP000001630: Chromosome I

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Fumarate and nitrate reduction regulatory protein
PRO_0000321853Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi345073.VC0395_A1045.

Structurei

3D structure databases

ProteinModelPortaliA5F890.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 23774HTH crp-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 3210Essential for the oxygen-regulated activity By similarity
Regioni50 – 534Activating region 2A Reviewed prediction
Regioni63 – 642Activating region 3A Reviewed prediction
Regioni74 – 785Activating region 1A Reviewed prediction
Regioni84 – 841Activating region 3B Reviewed prediction
Regioni88 – 903Activating region 3C Reviewed prediction
Regioni115 – 1151Activating region 3D Reviewed prediction
Regioni119 – 1246Activating region 1B Reviewed prediction
Regioni126 – 1272Activating region 2B Reviewed prediction
Regioni130 – 1312Activating region 2C Reviewed prediction
Regioni143 – 16220Dimerization Reviewed prediction
Add
BLAST
Regioni184 – 19411Activating region 1C Reviewed prediction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000186461.
KOiK01420.
OMAiFSANQFR.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5F890-1 [UniParc]FASTAAdd to Basket

« Hide

MISEKPAAKR IQSGGCAIHC QDCSISQLCI PFTLNESELD QLDQIIERKK    50
PIQKGQELFK AGDELRSLYA IRSGTIKSYT ITEQGDEQIT AFHLAGDLVG 100
FDAITGDQHP SFAQALETSM VCEIPYEILD DLSGKMPKLR QQIMRLMSNE 150
IKGDQEMILL LSKKNAEERL AAFLYNLSTR FSQRGFSPRE FRLTMTRGDI 200
GNYLGLTVET ISRLLGRFQK SEILSVKGKY ITILNHAELM ELAGVSKESK 250
Length:250
Mass (Da):28,071
Last modified:June 12, 2007 - v1
Checksum:iA3E3ED036BBBC490
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF244992 Genomic DNA. Translation: AAG09773.1.
CP000627 Genomic DNA. Translation: ABQ20599.1.
CP001235 Genomic DNA. Translation: ACP09560.1.
RefSeqiWP_000622582.1. NC_012582.1.
YP_001216991.1. NC_009457.1.
YP_002819796.1. NC_012582.1.

Genome annotation databases

EnsemblBacteriaiABQ20599; ABQ20599; VC0395_A1045.
ACP09560; ACP09560; VC395_1554.
GeneIDi5137220.
7775452.
KEGGivco:VC0395_A1045.
vcr:VC395_1554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF244992 Genomic DNA. Translation: AAG09773.1 .
CP000627 Genomic DNA. Translation: ABQ20599.1 .
CP001235 Genomic DNA. Translation: ACP09560.1 .
RefSeqi WP_000622582.1. NC_012582.1.
YP_001216991.1. NC_009457.1.
YP_002819796.1. NC_012582.1.

3D structure databases

ProteinModelPortali A5F890.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 345073.VC0395_A1045.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ20599 ; ABQ20599 ; VC0395_A1045 .
ACP09560 ; ACP09560 ; VC395_1554 .
GeneIDi 5137220.
7775452.
KEGGi vco:VC0395_A1045.
vcr:VC395_1554.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000186461.
KOi K01420.
OMAi FSANQFR.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view ]
PRINTSi PR00034. HTHCRP.
SMARTi SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The fnr gene of Vibrio cholerae."
    Krishnan H.H., Chowdhury R.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Heidelberg J.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395.
  3. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395.

Entry informationi

Entry nameiFNR_VIBC3
AccessioniPrimary (citable) accession number: A5F890
Secondary accession number(s): C3M0J4, Q9KS27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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