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A5F627

- LPXB_VIBC3

UniProt

A5F627 - LPXB_VIBC3

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:VC0395_A1838, VC395_2363
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
    Taxonomic identifieri345073 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000249: Chromosome 2, UP000001630: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379Lipid-A-disaccharide synthasePRO_1000072226Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi345073.VC0395_A1838.

    Structurei

    3D structure databases

    ProteinModelPortaliA5F627.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5F627-1 [UniParc]FASTAAdd to Basket

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    MNRPLRIGIV VGELSGDTLG EGFIKAIRAR YPDAEFVGIG GPKMNALGCQ    50
    SLFDMEELAV MGLVEVLGRL PRLLKVKAEL VKYFTANPPD VFVGIDAPDF 100
    NLRLELSLKQ AGIKTVHYVS PSVWAWRQNR IHGIAAATHL VLAFLPFEKA 150
    FYDKFNVPCE FIGHTLADSI PLASDKLAAR QLLGLDEQRR WLAVLPGSRG 200
    SEMKMLAEPF IATCQKLQAR YPDLGFVVAL VNAKRRAQFE QAWQQVAPEL 250
    NFVLVDDTAR NVITAADAVM LASGTVALEC MLLKRPMVVG YRVNAFTAFL 300
    AKRLLKTPYV SLPNILAGEE LVKELLQDHC TVDNLYHEVS RLLESDNQAL 350
    MDKFTEMHQW IRKDADQQAA QAVLHLIQK 379
    Length:379
    Mass (Da):42,250
    Last modified:June 12, 2007 - v1
    Checksum:i646808F3DDFA3CCE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000627 Genomic DNA. Translation: ABQ20419.1.
    CP001235 Genomic DNA. Translation: ACP10353.1.
    RefSeqiYP_001217762.1. NC_009457.1.
    YP_002820589.1. NC_012582.1.

    Genome annotation databases

    EnsemblBacteriaiABQ20419; ABQ20419; VC0395_A1838.
    ACP10353; ACP10353; VC395_2363.
    GeneIDi5135775.
    7776145.
    KEGGivco:VC0395_A1838.
    vcr:VC395_2363.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000627 Genomic DNA. Translation: ABQ20419.1 .
    CP001235 Genomic DNA. Translation: ACP10353.1 .
    RefSeqi YP_001217762.1. NC_009457.1.
    YP_002820589.1. NC_012582.1.

    3D structure databases

    ProteinModelPortali A5F627.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 345073.VC0395_A1838.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ20419 ; ABQ20419 ; VC0395_A1838 .
    ACP10353 ; ACP10353 ; VC395_2363 .
    GeneIDi 5135775.
    7776145.
    KEGGi vco:VC0395_A1838.
    vcr:VC395_2363.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Heidelberg J.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39541 / Classical Ogawa 395 / O395.
    2. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
      Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
      PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39541 / Classical Ogawa 395 / O395.

    Entry informationi

    Entry nameiLPXB_VIBC3
    AccessioniPrimary (citable) accession number: A5F627
    Secondary accession number(s): C3M3K4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3