ID   ASTD_VIBC3              Reviewed;         485 AA.
AC   A5F529;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase;
DE            EC=1.2.1.71;
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase;
DE            Short=SGSD;
GN   Name=astD; OrderedLocusNames=VC0395_A2193;
OS   Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Vibrio.
OX   NCBI_TaxID=345073;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Heidelberg J.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of
CC       succinylglutamate semialdehyde into succinylglutamate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
CC       + H(2)O = N-succinyl-L-glutamate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily.
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DR   EMBL; CP000627; ABQ21560.1; -; Genomic_DNA.
DR   RefSeq; YP_001218109.1; -.
DR   RefSeq; YP_002820950.1; -.
DR   GeneID; 5136636; -.
DR   GeneID; 7776458; -.
DR   GenomeReviews; CP000627_GR; VC0395_A2193.
DR   KEGG; vco:VC0395_A2193; -.
DR   OMA; A5F529; TNIAELP.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenas...; IEA:EC.
DR   GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01174; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR03240; arg_catab_astD; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    485       N-succinylglutamate 5-semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_1000073079.
FT   NP_BIND     220    225       NAD (By similarity).
FT   ACT_SITE    243    243       By similarity.
FT   ACT_SITE    278    278       By similarity.
SQ   SEQUENCE   485 AA;  52193 MW;  07E9FF9E24C091F2 CRC64;
     MTHWIAGEWV AGTGEKLESH TPYSHELLWQ GYSASGEQVD AAVKAARRAF LDWKKRPFAE
     REQKVLAFAE LVKANSEQIA QVIAKETGKP LWETRTEAAS IAGKIAISIR AYHERTGETV
     REAAGNQLVL RHRPLGVMAV FGPYNFPGHL PNGHIVPALL AGNTVVFKPS EQTPWTGEVL
     MQLWQQAGLP AGVINLVQGS KETGIALAQS RGIDGLLFTG SANTGHLLHR QFAGQPDKML
     ALEMGGNNPM VISEHYGDLD ATVYTIIQSA FISSGQRCTC VRRLYVPQGT KGDALLDKLV
     SVTAKLRIDQ PFAEPAPFMG PLVSEAAAQA ILKAQADLQA LGGKSLLEAR ALHAAFITPA
     IIDVTAIERL PDDEYFGPLL QVVRYQTLAQ AVELANDTRF GLSAGLVSTD DGEWDYFVEH
     IRAGIVNRNR QLTGASGDAP FGGPGASGNL RPSAFYAADY CAYPMASMEG DTTLLPATLS
     PGVEL
//