Reviewed, UniProtKB/Swiss-Prot A5F529 (ASTD_VIBC3)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	VC0395_A2193

Organism

Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) [Complete proteome] [HAMAP]

Taxonomic identifier

345073 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH.
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5.
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	N-succinylglutamate 5-semialdehyde dehydrogenase		PRO_1000073079
Regions
	Nucleotide binding	220 – 225	6	NAD By similarity
Sites
	Active site	243	1	By similarity
	Active site	278	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5F529-1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 07E9FF9E24C091F2	FASTA	485	52,193
	10 20 30 40 50 60 MTHWIAGEWV AGTGEKLESH TPYSHELLWQ GYSASGEQVD AAVKAARRAF LDWKKRPFAE 70 80 90 100 110 120 REQKVLAFAE LVKANSEQIA QVIAKETGKP LWETRTEAAS IAGKIAISIR AYHERTGETV 130 140 150 160 170 180 REAAGNQLVL RHRPLGVMAV FGPYNFPGHL PNGHIVPALL AGNTVVFKPS EQTPWTGEVL 190 200 210 220 230 240 MQLWQQAGLP AGVINLVQGS KETGIALAQS RGIDGLLFTG SANTGHLLHR QFAGQPDKML 250 260 270 280 290 300 ALEMGGNNPM VISEHYGDLD ATVYTIIQSA FISSGQRCTC VRRLYVPQGT KGDALLDKLV 310 320 330 340 350 360 SVTAKLRIDQ PFAEPAPFMG PLVSEAAAQA ILKAQADLQA LGGKSLLEAR ALHAAFITPA 370 380 390 400 410 420 IIDVTAIERL PDDEYFGPLL QVVRYQTLAQ AVELANDTRF GLSAGLVSTD DGEWDYFVEH 430 440 450 460 470 480 IRAGIVNRNR QLTGASGDAP FGGPGASGNL RPSAFYAADY CAYPMASMEG DTTLLPATLS PGVEL

References

[1]	Heidelberg J. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000627 Genomic DNA. Translation: ABQ21560.1.
RefSeq	YP_001218109.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5136636.
GenomeReviews	Gene locus VC0395_A2193 in contig CP000627_GR.
KEGG	vco:VC0395_A2193.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_VIBC3

Accession

Primary (citable) accession number: A5F529

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 12, 2007
Last modified:	November 25, 2008
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)