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Reviewed, UniProtKB/Swiss-Prot A5F520 (DMA_VIBC3)

Last modified November 3, 2009. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    DNA adenine methylase
    EC=2.1.1.72
Alternative name(s):
    M.VchADam
    Deoxyadenosyl-methyltransferase
    DNA adenine methyltransferase
Gene names
Name: dam
Ordered Locus Names: VC0395_A2203
OrganismVibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) [Complete proteome] [HAMAP]
Taxonomic identifier345073 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Methylates DNA within the sequence GATC. Directly involved in methyl-directed DNA mismatch repair By similarity.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277DNA adenine methylase
PRO_0000324810

Sites

Binding site101S-adenosyl-L-methionine By similarity
Binding site141S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding site541S-adenosyl-L-methionine By similarity
Binding site1811S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
A5F520-1 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 48D831240F9E7C60

FASTA27731,624
        10         20         30         40         50         60 
MKKQRAFLKW AGGKYSLVED IQRHLPEARE LVEPFVGAGS VFLNTDFERY LLADINPDLI 

        70         80         90        100        110        120 
NFYNLLKTEP QAYIHEAKRW FVPENNRKEV YLDIRKQFNQ SDDAMFRSLA FLYMNRFGFN 

       130        140        150        160        170        180 
GLCRYNKKGG FNVPFGSYKK PYFPEQELEF FAEKAQRATF ICASYGETFA RAQSDSVIYC 

       190        200        210        220        230        240 
DPPYAPLSTT ANFTSYAGNG FTLDDQAALA DIAEKTAKER GISVLISNHD TTHTRRLYRG 

       250        260        270 
AQLNVVKANR TISRNGAGRN KVDELLALFT PHLSSQA 

« Hide

References

« Hide 'large scale' references
[1]"DNA adenine methylase is essential for viability and plays a role in the pathogenesis of Yersinia pseudotuberculosis and Vibrio cholerae."
Julio S.M., Heithoff D.M., Provenzano D., Klose K.E., Sinsheimer R.L., Low D.A., Mahan M.J.
Infect. Immun. 69:7610-7615(2001) [PubMed: 11705940] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Heidelberg J.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

AF274317 Genomic DNA. Translation: AAG23174.1.
CP000627 Genomic DNA. Translation: ABQ21457.1.

3D structure databases

HSSPHSSP built from PDB template 2DPM based on UniProtKB P04043.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5F520.

Protein family/group databases

REBASE5786. M.VchO395Dam.

Genome annotation databases

GenomeReviewsGene locus VC0395_A2203 in contig CP000627_GR.
KEGGvco:VC0395_A2203.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMATSAFTSY.

Family and domain databases

InterProIPR002294. D12N6_MeTrfase.
IPR012326. Dam.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012327. MeTrfase_D12.
[Graphical view]
PfamPF02086. MethyltransfD12. 1 hit.
[Graphical view]
PRINTSPR00505. D12N6MTFRASE.
TIGRFAMsTIGR00571. dam. 1 hit.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDMA_VIBC3
AccessionPrimary (citable) accession number: A5F520
Secondary accession number(s): Q08318, Q9KNV4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 12, 2007
Last modified: November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents