A5F4Z7 (ARGE_VIBC3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylornithine deacetylase
Short name=AO
Short name=Acetylornithinase
EC=3.5.1.16

Alternative name(s):
N-acetylornithinase
Short name=NAO

Gene names

Name:	argE
Ordered Locus Names:	VC0395_A2221, VC395_2758

Organism

Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) [Complete proteome] [HAMAP]

Taxonomic identifier

345073 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine. HAMAP MF_01108
Cofactor	Binds 2 zinc or cobalt ions per subunit By similarity. HAMAP MF_01108 Glutathione By similarity. HAMAP MF_01108
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1. HAMAP MF_01108
Subunit structure	Homodimer By similarity. HAMAP MF_01108
Subcellular location	Cytoplasm Probable HAMAP MF_01108.
Sequence similarities	Belongs to the peptidase M20A family. ArgE subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	Cobalt Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetylornithine deacetylase activity Inferred from electronic annotation. Source: EC cobalt ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	Acetylornithine deacetylase HAMAP MF_01108		PRO_1000073029
Sites
	Active site	78	1	By similarity
	Active site	140	1	By similarity
	Metal binding	76	1	Cobalt or zinc 1 By similarity
	Metal binding	108	1	Cobalt or zinc 1 By similarity
	Metal binding	108	1	Cobalt or zinc 2 By similarity
	Metal binding	141	1	Cobalt or zinc 2 By similarity
	Metal binding	165	1	Cobalt or zinc 1 By similarity
	Metal binding	351	1	Cobalt or zinc 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5F4Z7 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: F0CC5EC1892ECE8D	FASTA	378	41,964
	10 20 30 40 50 60 MPLPSFLEVY EGLISTSSIS STDARWDEGN EQVIAKLADW LSALGFSIQI EQVAPNKQNL 70 80 90 100 110 120 IAKLGSGEGG LLLAGHSDTV PFDEGRWNYN PHALTQVNNR FYGLGTADMK GFFAFIYEAV 130 140 150 160 170 180 KNVDWSKQTK PLYVLATCDE ETTMLGARHF TENAPFKPDY CIIGEPTSLV PIRAHKGHVA 190 200 210 220 230 240 NAIRVTGKSG HSSNPALGVN AIEIMHEVLF ALMQLRDRLI KEYHHPGFEI PTPTLNLGHI 250 260 270 280 290 300 HGGDSPNRIC GCCELHYDVR PLPGISLDGL DNLMHDALRE VQQKWPGRIE LVPLHDPIPG 310 320 330 340 350 360 YECAHDHPFI HGISEICEQE AQTVNYCTEA PFLQQVCPTL VLGPGSIDQA HQPDEFLAFE 370 FIDPTVRVLS RAMQKYCF

References

[1]	Heidelberg J. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39541 / Ogawa 395 / O395.
[2]	"A recalibrated molecular clock and independent origins for the cholera pandemic clones." Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L. PLoS ONE 3:E4053-E4053(2008) [PubMed: 19115014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39541 / Ogawa 395 / O395.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000627 Genomic DNA. Translation: ABQ20373.1. CP001235 Genomic DNA. Translation: ACP10743.1.
3D structure databases
ProteinModelPortal	A5F4Z7.
ModBase	Search...
Protein-protein interaction databases
STRING	A5F4Z7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GenomeReviews	Gene locus VC0395_A2221 in contig CP000627_GR. Gene locus VC395_2758 in contig CP001235_GR.
KEGG	vco:VC0395_A2221.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0624.
HOGENOM	HBG728841.
OMA	DIACAHQ.
ProtClustDB	PRK05111.
Enzyme and pathway databases
BioCyc	VCHO345073:VC0395_A2221-MONOMER.
Family and domain databases
HAMAP	MF_01108. ArgE. [Tree]
InterPro	IPR010169. AcOrn-deacetyl. IPR001261. ArgE/DapE_CS. IPR002933. Peptidase_M20. IPR011650. Peptidase_M20_dimer. [Graphical view]
KO	K01438.
Pfam	PF07687. M20_dimer. 1 hit. PF01546. Peptidase_M20. 1 hit. [Graphical view]
SUPFAM	SSF55031. Peptidase_M20_dimer. 1 hit.
TIGRFAMs	TIGR01892. AcOrn-deacetyl. 1 hit.
PROSITE	PS00758. ARGE_DAPE_CPG2_1. 1 hit. PS00759. ARGE_DAPE_CPG2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGE_VIBC3

Accession

Primary (citable) accession number: A5F4Z7
Secondary accession number(s): C3LXP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 12, 2007
Last modified:	November 16, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program