A5F4K5 (STHA_VIBC3) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 39.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Soluble pyridine nucleotide transhydrogenase Short name=STH EC=1.6.1.1 Alternative name(s): NAD(P)(+) transhydrogenase [B-specific] | ||||||
| Gene names |
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| Organism | Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 345073 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio |
Protein attributes
| Sequence length | 466 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity. HAMAP MF_00247 |
| Catalytic activity | NADPH + NAD+ = NADP+ + NADH. HAMAP MF_00247 |
| Cofactor | Binds 1 FAD per subunit By similarity. HAMAP MF_00247 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00247. |
| Sequence similarities | Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | FAD Flavoprotein NAD NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell redox homeostasis Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 466 | 466 | Soluble pyridine nucleotide transhydrogenase HAMAP MF_00247 | PRO_1000071844 | |||||
Regions | |||||||||
| Nucleotide binding | 36 – 45 | 10 | FAD By similarity | ||||||
Sequences
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References
| [1] | Heidelberg J. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39541 / Ogawa 395 / O395. |
| [2] | "A recalibrated molecular clock and independent origins for the cholera pandemic clones." Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L. PLoS ONE 3:E4053-E4053(2008) [PubMed: 19115014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39541 / Ogawa 395 / O395. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000627 Genomic DNA. Translation: ABQ21088.1. CP001235 Genomic DNA. Translation: ACP08058.1. |
3D structure databases | |
| ProteinModelPortal | A5F4K5. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A5F4K5. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GenomeReviews | Gene locus VC0395_A2370 in contig CP000627_GR. Gene locus VC395_0029 in contig CP001235_GR. |
| KEGG | vco:VC0395_A2370. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1249. |
| HOGENOM | HBG515043. |
| OMA | GEGNTIE. |
| ProtClustDB | PRK05249. |
Enzyme and pathway databases | |
| BioCyc | VCHO345073:VC0395_A2370-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00247. SthA. [Tree] |
| InterPro | IPR016156. FAD/NAD-linked_Rdtase_dimer. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR022962. STH. [Graphical view] |
| Gene3D | G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit. |
| KO | K00322. |
| Pfam | PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view] |
| PRINTS | PR00368. FADPNR. |
| SUPFAM | SSF55424. FAD/NAD-linked_reductase_dimer. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | STHA_VIBC3 | ||||||||
| Accession | Primary (citable) accession number: A5F4K5 Secondary accession number(s): C3M294 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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