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A5F3R3 (GPPA_VIBC3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:VC0395_A2696, VC395_0348
OrganismVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) [Complete proteome] [HAMAP]
Taxonomic identifier345073 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_1000073559

Sequences

Sequence LengthMass (Da)Tools
A5F3R3 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: BB0BD17FF3B3A331

FASTA49754,826
        10         20         30         40         50         60 
MSQAVSSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE HNALSLDAMQ 

        70         80         90        100        110        120 
RGWDCLSLFA ERLQDIPAEN IRIVGTATLR TATNAGEFIA KANQILGHPI DVISGEEEAA 

       130        140        150        160        170        180 
TIYKGVAHTS GGLGRRLVVD IGGASTELII GEGFEAKALT SLKMGCVTWL ERHFKDRQLT 

       190        200        210        220        230        240 
ATNFNNAILA AKQMLDPILT QYTELGWNVC VGASGTVQAL QEIMLAQGMD EVITLTKLKR 

       250        260        270        280        290        300 
LQKQAMLADH LEELDIEGLT LERALVFPSG LSILIAIFES LNIEAMTLAG GALREGLVYE 

       310        320        330        340        350        360 
MVQDLRQEDI RARTIRCVQT RYQIDSAYGD QVATLASKLL AQCGGEAWIN EPQAEMLLRT 

       370        380        390        400        410        420 
AAKLHEIGLT IDFKKGGEHS AYLLQHLDLP GYTRAQKHYL GEIVRRYREQ LTSLPEQYAL 

       430        440        450        460        470        480 
SGTSGKRVLR LLRLAVLLSH RRSPALEPMV ELSAQEDKLT LTLDGEWLAK NPLTRTELEL 

       490 
EANRQTDIGW PLSIECH 

« Hide

References

[1]Heidelberg J.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39541 / Classical Ogawa 395 / O395.
[2]"A recalibrated molecular clock and independent origins for the cholera pandemic clones."
Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39541 / Classical Ogawa 395 / O395.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000627 Genomic DNA. Translation: ABQ19640.1.
CP001235 Genomic DNA. Translation: ACP08373.1.
RefSeqYP_001218574.1. NC_009457.1.
YP_002818609.1. NC_012582.1.

3D structure databases

ProteinModelPortalA5F3R3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING345073.VC0395_A2696.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ19640; ABQ19640; VC0395_A2696.
ACP08373; ACP08373; VC395_0348.
GeneID5136624.
7774419.
KEGGvco:VC0395_A2696.
vcr:VC395_0348.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAPPRVAEH.
ProtClustDBPRK11031.

Enzyme and pathway databases

UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_VIBC3
AccessionPrimary (citable) accession number: A5F3R3
Secondary accession number(s): C3M3W5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways