SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A5F3R3

- GPPA_VIBC3

UniProt

A5F3R3 - GPPA_VIBC3

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
Gene
gppA, VC0395_A2696, VC395_0348
Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:VC0395_A2696, VC395_0348
OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Taxonomic identifieri345073 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000249: Chromosome 2, UP000001630: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation
PRO_1000073559Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi345073.VC0395_A2696.

Structurei

3D structure databases

ProteinModelPortaliA5F3R3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiGLHIEYK.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5F3R3-1 [UniParc]FASTAAdd to Basket

« Hide

MSQAVSSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE    50
HNALSLDAMQ RGWDCLSLFA ERLQDIPAEN IRIVGTATLR TATNAGEFIA 100
KANQILGHPI DVISGEEEAA TIYKGVAHTS GGLGRRLVVD IGGASTELII 150
GEGFEAKALT SLKMGCVTWL ERHFKDRQLT ATNFNNAILA AKQMLDPILT 200
QYTELGWNVC VGASGTVQAL QEIMLAQGMD EVITLTKLKR LQKQAMLADH 250
LEELDIEGLT LERALVFPSG LSILIAIFES LNIEAMTLAG GALREGLVYE 300
MVQDLRQEDI RARTIRCVQT RYQIDSAYGD QVATLASKLL AQCGGEAWIN 350
EPQAEMLLRT AAKLHEIGLT IDFKKGGEHS AYLLQHLDLP GYTRAQKHYL 400
GEIVRRYREQ LTSLPEQYAL SGTSGKRVLR LLRLAVLLSH RRSPALEPMV 450
ELSAQEDKLT LTLDGEWLAK NPLTRTELEL EANRQTDIGW PLSIECH 497
Length:497
Mass (Da):54,826
Last modified:June 12, 2007 - v1
Checksum:iBB0BD17FF3B3A331
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000627 Genomic DNA. Translation: ABQ19640.1.
CP001235 Genomic DNA. Translation: ACP08373.1.
RefSeqiYP_001218574.1. NC_009457.1.
YP_002818609.1. NC_012582.1.

Genome annotation databases

EnsemblBacteriaiABQ19640; ABQ19640; VC0395_A2696.
ACP08373; ACP08373; VC395_0348.
GeneIDi5136624.
7774419.
KEGGivco:VC0395_A2696.
vcr:VC395_0348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000627 Genomic DNA. Translation: ABQ19640.1 .
CP001235 Genomic DNA. Translation: ACP08373.1 .
RefSeqi YP_001218574.1. NC_009457.1.
YP_002818609.1. NC_012582.1.

3D structure databases

ProteinModelPortali A5F3R3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 345073.VC0395_A2696.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ19640 ; ABQ19640 ; VC0395_A2696 .
ACP08373 ; ACP08373 ; VC395_0348 .
GeneIDi 5136624.
7774419.
KEGGi vco:VC0395_A2696.
vcr:VC395_0348.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi GLHIEYK.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Heidelberg J.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395.
  2. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395.

Entry informationi

Entry nameiGPPA_VIBC3
AccessioniPrimary (citable) accession number: A5F3R3
Secondary accession number(s): C3M3W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi