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A5F3R3

- GPPA_VIBC3

UniProt

A5F3R3 - GPPA_VIBC3

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:VC0395_A2696, VC395_0348
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
    Taxonomic identifieri345073 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000249: Chromosome 2, UP000001630: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000073559Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi345073.VC0395_A2696.

    Structurei

    3D structure databases

    ProteinModelPortaliA5F3R3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiGLHIEYK.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5F3R3-1 [UniParc]FASTAAdd to Basket

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    MSQAVSSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE    50
    HNALSLDAMQ RGWDCLSLFA ERLQDIPAEN IRIVGTATLR TATNAGEFIA 100
    KANQILGHPI DVISGEEEAA TIYKGVAHTS GGLGRRLVVD IGGASTELII 150
    GEGFEAKALT SLKMGCVTWL ERHFKDRQLT ATNFNNAILA AKQMLDPILT 200
    QYTELGWNVC VGASGTVQAL QEIMLAQGMD EVITLTKLKR LQKQAMLADH 250
    LEELDIEGLT LERALVFPSG LSILIAIFES LNIEAMTLAG GALREGLVYE 300
    MVQDLRQEDI RARTIRCVQT RYQIDSAYGD QVATLASKLL AQCGGEAWIN 350
    EPQAEMLLRT AAKLHEIGLT IDFKKGGEHS AYLLQHLDLP GYTRAQKHYL 400
    GEIVRRYREQ LTSLPEQYAL SGTSGKRVLR LLRLAVLLSH RRSPALEPMV 450
    ELSAQEDKLT LTLDGEWLAK NPLTRTELEL EANRQTDIGW PLSIECH 497
    Length:497
    Mass (Da):54,826
    Last modified:June 12, 2007 - v1
    Checksum:iBB0BD17FF3B3A331
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000627 Genomic DNA. Translation: ABQ19640.1.
    CP001235 Genomic DNA. Translation: ACP08373.1.
    RefSeqiYP_001218574.1. NC_009457.1.
    YP_002818609.1. NC_012582.1.

    Genome annotation databases

    EnsemblBacteriaiABQ19640; ABQ19640; VC0395_A2696.
    ACP08373; ACP08373; VC395_0348.
    GeneIDi5136624.
    7774419.
    KEGGivco:VC0395_A2696.
    vcr:VC395_0348.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000627 Genomic DNA. Translation: ABQ19640.1 .
    CP001235 Genomic DNA. Translation: ACP08373.1 .
    RefSeqi YP_001218574.1. NC_009457.1.
    YP_002818609.1. NC_012582.1.

    3D structure databases

    ProteinModelPortali A5F3R3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 345073.VC0395_A2696.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ19640 ; ABQ19640 ; VC0395_A2696 .
    ACP08373 ; ACP08373 ; VC395_0348 .
    GeneIDi 5136624.
    7774419.
    KEGGi vco:VC0395_A2696.
    vcr:VC395_0348.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi GLHIEYK.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Heidelberg J.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39541 / Classical Ogawa 395 / O395.
    2. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
      Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
      PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39541 / Classical Ogawa 395 / O395.

    Entry informationi

    Entry nameiGPPA_VIBC3
    AccessioniPrimary (citable) accession number: A5F3R3
    Secondary accession number(s): C3M3W5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3