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A5F3I6 (CYSH_VIBC3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoadenosine phosphosulfate reductase

EC=1.8.4.8
Alternative name(s):
3'-phosphoadenylylsulfate reductase
PAPS reductase, thioredoxin dependent
PAPS sulfotransferase
PAdoPS reductase
Gene names
Name:cysH
Ordered Locus Names:VC0395_A2797, VC395_0430
OrganismVibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) [Complete proteome] [HAMAP]
Taxonomic identifier345073 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reduction of activated sulfate into sulfite. HAMAP MF_00063

Catalytic activity

Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin. HAMAP MF_00063

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3. HAMAP MF_00063

Subcellular location

Cytoplasm By similarity HAMAP MF_00063.

Sequence similarities

Belongs to the PAPS reductase family. CysH subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 253253Phosphoadenosine phosphosulfate reductase HAMAP MF_00063
PRO_1000071166

Sequences

Sequence LengthMass (Da)Tools
A5F3I6 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: A92EF4BEE08A9FFD

FASTA25329,249
        10         20         30         40         50         60 
MPNRTVPTLE ELLTLNKVQQ TLRLTEVNQH LESLTAQERV VWGLENLQGN HALSSSFGIQ 

        70         80         90        100        110        120 
AAVMLHLLTS VKSDIPVVLT DTGYLFPETY QFIDELTERL NLNLKVYSAP VSAAWQEARY 

       130        140        150        160        170        180 
GKLWEQGVEG IERYNQINKV EPMRRALDEL NIGTWFSGLR REQSQSRASL PILSVQNGVF 

       190        200        210        220        230        240 
KFLPVIDWTN KEVHYYLKDN DLPYHPLWEQ GYLSVGDTHT TQKWQPGMNE EQTRFFGLKR 

       250 
ECGLHEDHND THQ 

« Hide

References

[1]Heidelberg J.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39541 / Ogawa 395 / O395.
[2]"A recalibrated molecular clock and independent origins for the cholera pandemic clones."
Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
PLoS ONE 3:E4053-E4053(2008) [PubMed: 19115014] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39541 / Ogawa 395 / O395.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000627 Genomic DNA. Translation: ABQ21825.1.
CP001235 Genomic DNA. Translation: ACP08452.1.

3D structure databases

ProteinModelPortalA5F3I6.
SMRA5F3I6. Positions 9-246.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5F3I6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GenomeReviewsGene locus VC0395_A2797 in contig CP000627_GR.
Gene locus VC395_0430 in contig CP001235_GR.
KEGGvco:VC0395_A2797.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0175.
HOGENOMHBG758022.
OMAAIHGTRF.
ProtClustDBPRK02090.

Enzyme and pathway databases

BioCycVCHO345073:VC0395_A2797-MONOMER.

Family and domain databases

HAMAPMF_00063. CysH.
[Tree]
InterProIPR004511. PAPS/APS_Rdtase.
IPR002500. PAPS_reduct.
IPR011800. PAPS_reductase_CysH.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK00390.
PfamPF01507. PAPS_reduct. 1 hit.
[Graphical view]
TIGRFAMsTIGR00434. CysH. 1 hit.
TIGR02057. PAPS_reductase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCYSH_VIBC3
AccessionPrimary (citable) accession number: A5F3I6
Secondary accession number(s): C3M4I0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families