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A5F3A7

- ALDH_VIBC3

UniProt

A5F3A7 - ALDH_VIBC3

Protein

Aldehyde dehydrogenase

Gene

aldA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    May be involved in V.cholerae virulence, as its expression is under the control of ToxR, a transcriptional activator of several genes associated with virulence.By similarity

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei262 – 2621By similarity
    Active sitei301 – 3011By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi240 – 2456NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway
    2. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Virulence

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase (EC:1.2.1.3)
    Gene namesi
    Name:aldA
    Synonyms:aldA-1
    Ordered Locus Names:VC0395_A0344, VC395_0836
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
    Taxonomic identifieri345073 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000249: Chromosome 2, UP000001630: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Aldehyde dehydrogenasePRO_0000321860Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi345073.VC0395_A0344.

    Structurei

    3D structure databases

    ProteinModelPortaliA5F3A7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00128.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5F3A7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIYPIPNSET STVHFKDVYD NYIGGQWMKP HSGEYFSNTS PVNGLVFCRV    50
    ARSSSQDVEL ALDAAHNALE SWSTTSAVER SNILLRIADR IESNLETLAI 100
    VESWDNGKPI RETLAADLPL TIDHFRYFAA CIRSQEGAAS ELDSRTLTYH 150
    LPEPIGVVGQ IIPWNFPLLM AAWKLAPALA AGCTVVLKPA EQTPVSILFL 200
    MEIIGDLIPA GVINVVNGFG SEAGNALATS QRIDKLAFTG STEIGNHILK 250
    CAADNLIPST IELGGKSPNI YFPDIFSHED QYLDKCIEGA LLAFFNQGEV 300
    CTCPSRILVH ESIYEKFIAK IIERVALIKQ GNPLDTETQI GAQVSKEQYD 350
    KILGYIQIGK DEGAELIFGG HPNNQENYLS GGYYIKPTLF FGHNQMHIFQ 400
    EEIFGPVIAI TKFKDEIEAL HLANDTVYGL GAGVWTRDIN IAHRMAKNIK 450
    AGRVWVNCYH AYPAHAAFGG YKKSGIGRET HKLTLSHYQN IKNVLISHEI 500
    HPLGLF 506
    Length:506
    Mass (Da):55,885
    Last modified:February 26, 2008 - v2
    Checksum:i69E7F561D6CFED07
    GO

    Sequence cautioni

    The sequence ABQ21488.1 differs from that shown. Reason: Erroneous initiation.
    The sequence ACP08852.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325733 Genomic DNA. Translation: AAK20747.1.
    CP000627 Genomic DNA. Translation: ABQ21488.1. Different initiation.
    CP001235 Genomic DNA. Translation: ACP08852.1. Different initiation.
    RefSeqiYP_001216300.1. NC_009457.1.
    YP_002819088.1. NC_012582.1.

    Genome annotation databases

    EnsemblBacteriaiABQ21488; ABQ21488; VC0395_A0344.
    ACP08852; ACP08852; VC395_0836.
    GeneIDi5136121.
    7776581.
    KEGGivco:VC0395_A0344.
    vcr:VC395_0836.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325733 Genomic DNA. Translation: AAK20747.1 .
    CP000627 Genomic DNA. Translation: ABQ21488.1 . Different initiation.
    CP001235 Genomic DNA. Translation: ACP08852.1 . Different initiation.
    RefSeqi YP_001216300.1. NC_009457.1.
    YP_002819088.1. NC_012582.1.

    3D structure databases

    ProteinModelPortali A5F3A7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 345073.VC0395_A0344.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ21488 ; ABQ21488 ; VC0395_A0344 .
    ACP08852 ; ACP08852 ; VC395_0836 .
    GeneIDi 5136121.
    7776581.
    KEGGi vco:VC0395_A0344.
    vcr:VC395_0836.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00128.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of Vibrio cholerae pathogenicity islands in sixth and seventh pandemic strains."
      Karaolis D.K.R., Lan R., Kaper J.B., Reeves P.R.
      Infect. Immun. 69:1947-1952(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Heidelberg J.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39541 / Classical Ogawa 395 / O395.
    3. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
      Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
      PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39541 / Classical Ogawa 395 / O395.

    Entry informationi

    Entry nameiALDH_VIBC3
    AccessioniPrimary (citable) accession number: A5F3A7
    Secondary accession number(s): C3LYI6, P23240, Q9KTS0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3