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A5F3A7

- ALDH_VIBC3

UniProt

A5F3A7 - ALDH_VIBC3

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Protein

Aldehyde dehydrogenase

Gene

aldA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

May be involved in V.cholerae virulence, as its expression is under the control of ToxR, a transcriptional activator of several genes associated with virulence.By similarity

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei262 – 2621By similarity
Active sitei301 – 3011By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi240 – 2456NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
  2. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Virulence

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase (EC:1.2.1.3)
Gene namesi
Name:aldA
Synonyms:aldA-1
Ordered Locus Names:VC0395_A0344, VC395_0836
OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Taxonomic identifieri345073 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000249: Chromosome 2, UP000001630: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Aldehyde dehydrogenasePRO_0000321860Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi345073.VC0395_A0344.

Structurei

3D structure databases

ProteinModelPortaliA5F3A7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00128.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5F3A7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIYPIPNSET STVHFKDVYD NYIGGQWMKP HSGEYFSNTS PVNGLVFCRV
60 70 80 90 100
ARSSSQDVEL ALDAAHNALE SWSTTSAVER SNILLRIADR IESNLETLAI
110 120 130 140 150
VESWDNGKPI RETLAADLPL TIDHFRYFAA CIRSQEGAAS ELDSRTLTYH
160 170 180 190 200
LPEPIGVVGQ IIPWNFPLLM AAWKLAPALA AGCTVVLKPA EQTPVSILFL
210 220 230 240 250
MEIIGDLIPA GVINVVNGFG SEAGNALATS QRIDKLAFTG STEIGNHILK
260 270 280 290 300
CAADNLIPST IELGGKSPNI YFPDIFSHED QYLDKCIEGA LLAFFNQGEV
310 320 330 340 350
CTCPSRILVH ESIYEKFIAK IIERVALIKQ GNPLDTETQI GAQVSKEQYD
360 370 380 390 400
KILGYIQIGK DEGAELIFGG HPNNQENYLS GGYYIKPTLF FGHNQMHIFQ
410 420 430 440 450
EEIFGPVIAI TKFKDEIEAL HLANDTVYGL GAGVWTRDIN IAHRMAKNIK
460 470 480 490 500
AGRVWVNCYH AYPAHAAFGG YKKSGIGRET HKLTLSHYQN IKNVLISHEI

HPLGLF
Length:506
Mass (Da):55,885
Last modified:February 26, 2008 - v2
Checksum:i69E7F561D6CFED07
GO

Sequence cautioni

The sequence ABQ21488.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence ACP08852.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325733 Genomic DNA. Translation: AAK20747.1.
CP000627 Genomic DNA. Translation: ABQ21488.1. Different initiation.
CP001235 Genomic DNA. Translation: ACP08852.1. Different initiation.
RefSeqiYP_001216300.1. NC_009457.1.
YP_002819088.1. NC_012582.1.

Genome annotation databases

EnsemblBacteriaiABQ21488; ABQ21488; VC0395_A0344.
ACP08852; ACP08852; VC395_0836.
GeneIDi5136121.
7776581.
KEGGivco:VC0395_A0344.
vcr:VC395_0836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325733 Genomic DNA. Translation: AAK20747.1 .
CP000627 Genomic DNA. Translation: ABQ21488.1 . Different initiation.
CP001235 Genomic DNA. Translation: ACP08852.1 . Different initiation.
RefSeqi YP_001216300.1. NC_009457.1.
YP_002819088.1. NC_012582.1.

3D structure databases

ProteinModelPortali A5F3A7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 345073.VC0395_A0344.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ21488 ; ABQ21488 ; VC0395_A0344 .
ACP08852 ; ACP08852 ; VC395_0836 .
GeneIDi 5136121.
7776581.
KEGGi vco:VC0395_A0344.
vcr:VC395_0836.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00128.

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparison of Vibrio cholerae pathogenicity islands in sixth and seventh pandemic strains."
    Karaolis D.K.R., Lan R., Kaper J.B., Reeves P.R.
    Infect. Immun. 69:1947-1952(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Heidelberg J.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395.
  3. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395.

Entry informationi

Entry nameiALDH_VIBC3
AccessioniPrimary (citable) accession number: A5F3A7
Secondary accession number(s): C3LYI6, P23240, Q9KTS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 1, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3