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Reviewed, UniProtKB/Swiss-Prot A5F3A7 (ALDH_VIBC3)

Last modified November 24, 2009. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Aldehyde dehydrogenase
    EC=1.2.1.3
Gene names
Name: aldA
Ordered Locus Names: VC0395_A0344
OrganismVibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) [Complete proteome] [HAMAP]
Taxonomic identifier345073 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

May be involved in V.cholerae virulence, as its expression is under the control of toxR, a transcriptional activator of several genes associated with virulence By similarity.

Catalytic activity

An aldehyde + NAD+ + H2O = an acid + NADH.

Pathway

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processVirulence
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

pathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 506506Aldehyde dehydrogenase
PRO_0000321860

Regions

Nucleotide binding240 – 2456NAD By similarity

Sites

Active site2621 By similarity
Active site3011 By similarity

Sequences

Sequence LengthMass (Da)Tools
A5F3A7-1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 69E7F561D6CFED07

FASTA50655,885
        10         20         30         40         50         60 
MIYPIPNSET STVHFKDVYD NYIGGQWMKP HSGEYFSNTS PVNGLVFCRV ARSSSQDVEL 

        70         80         90        100        110        120 
ALDAAHNALE SWSTTSAVER SNILLRIADR IESNLETLAI VESWDNGKPI RETLAADLPL 

       130        140        150        160        170        180 
TIDHFRYFAA CIRSQEGAAS ELDSRTLTYH LPEPIGVVGQ IIPWNFPLLM AAWKLAPALA 

       190        200        210        220        230        240 
AGCTVVLKPA EQTPVSILFL MEIIGDLIPA GVINVVNGFG SEAGNALATS QRIDKLAFTG 

       250        260        270        280        290        300 
STEIGNHILK CAADNLIPST IELGGKSPNI YFPDIFSHED QYLDKCIEGA LLAFFNQGEV 

       310        320        330        340        350        360 
CTCPSRILVH ESIYEKFIAK IIERVALIKQ GNPLDTETQI GAQVSKEQYD KILGYIQIGK 

       370        380        390        400        410        420 
DEGAELIFGG HPNNQENYLS GGYYIKPTLF FGHNQMHIFQ EEIFGPVIAI TKFKDEIEAL 

       430        440        450        460        470        480 
HLANDTVYGL GAGVWTRDIN IAHRMAKNIK AGRVWVNCYH AYPAHAAFGG YKKSGIGRET 

       490        500 
HKLTLSHYQN IKNVLISHEI HPLGLF 

« Hide

References

« Hide 'large scale' references
[1]"Comparison of Vibrio cholerae pathogenicity islands in sixth and seventh pandemic strains."
Karaolis D.K.R., Lan R., Kaper J.B., Reeves P.R.
Infect. Immun. 69:1947-1952(2001) [PubMed: 11179381] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Heidelberg J.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

AF325733 Genomic DNA. Translation: AAK20747.1.
CP000627 Genomic DNA. Translation: ABQ21488.1. Different initiation.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA5F3A7.

Genome annotation databases

GenomeReviewsGene locus VC0395_A0344 in contig CP000627_GR.
KEGGvco:VC0395_A0344.

Organism-specific databases

CMRSearch...

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH_VIBC3
AccessionPrimary (citable) accession number: A5F3A7
Secondary accession number(s): P23240, Q9KTS0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 24, 2009
This is version 18 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents