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A5F292

- A5F292_VIBC3

UniProt

A5F292 - A5F292_VIBC3

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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent, monomeric type

Gene
icd, VC0395_A0711, VC395_1208
Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471Substrate By similarity
Sitei257 – 2571Critical for catalysis By similarityUniRule annotation
Metal bindingi352 – 3521Magnesium or manganese By similarityUniRule annotation
Sitei422 – 4221Critical for catalysis By similarityUniRule annotation
Binding sitei549 – 5491Substrate By similarityUniRule annotation
Metal bindingi550 – 5501Magnesium or manganese By similarityUniRule annotation
Metal bindingi554 – 5541Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependent, monomeric typeImported (EC:1.1.1.42Imported)
Submitted name:
NADP-dependent isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:VC0395_A0711Imported, VC395_1208Imported
OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)Imported
Taxonomic identifieri345073 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001630: Chromosome I, UP000000249: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi345073.VC0395_A0711.

Structurei

3D structure databases

ProteinModelPortaliA5F292.
SMRiA5F292. Positions 6-739.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate binding By similarity

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A5F292-1 [UniParc]FASTAAdd to Basket

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MPTNKPTIIY TITDEAPALA TYSLLPIIQS FTASSGINVE TRDISLAGRI    50
LANFPEHLTE EQRISDALTE LGELAKTPEA NIIKLPNISA SVPQLKAAIK 100
ELQDKGYALP NYPEEPSSYE EEAIKATYDK IKGSAVNPVL REGNSDRRAP 150
ASVKNYAKKN PHSMGAWSKD SKSHVASMSD KDFFGSEKSM TVSGATKVAI 200
EFVGKEGAVK VLKKPFALQD KEIIDTSVMS KKALIAFFEK EIADAKAQDV 250
LFSLHMKATM MKVSDPVIFG HAVKVYYKAV FDKYGQLFDQ LGVDVNNGLG 300
DVYAKIQSLP EAQRAEIEAA IQAVYATQPA LAMVDSDRGI TNLHVPSDVI 350
VDASMPAMIR TSGQMWGPDG KQKDTKATIP DRCYAGVYQT VIDFCKQHGA 400
FDPTTMGSVP NVGLMAQKAE EYGSHDKTFI LDAEGVVRVI DEAGKVLLEQ 450
SVEAGDIFRM CQVKDAPIQD WVKLAVTRAR ASNTPAVFWL DPARAHDAEL 500
IKKVNQYLPN HDTSGLEIKI LSPIEATQYS LVRMKAGQDT ISVTGNVLRD 550
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQVQKENH 600
LRWDSLGEFL ALAASLEHLS VVTGNRKAQV LADALDKATG KFLDMNKSPS 650
RRVGEIDNRG SHFYLATYWA QALAEQTADA DLAAEFAPIA KALEEKEAQI 700
VAELNGAQGK PGDLGGYYAP EFAKVAPLMR PSSTFNAIID R 741
Length:741
Mass (Da):80,531
Last modified:June 12, 2007 - v1
Checksum:i9442576499BA54A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000627 Genomic DNA. Translation: ABQ19957.1.
CP001235 Genomic DNA. Translation: ACP09218.1.
RefSeqiYP_001216661.1. NC_009457.1.
YP_002819454.1. NC_012582.1.

Genome annotation databases

EnsemblBacteriaiABQ19957; ABQ19957; VC0395_A0711.
ACP09218; ACP09218; VC395_1208.
GeneIDi5137167.
7775156.
KEGGivco:VC0395_A0711.
vcr:VC395_1208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000627 Genomic DNA. Translation: ABQ19957.1 .
CP001235 Genomic DNA. Translation: ACP09218.1 .
RefSeqi YP_001216661.1. NC_009457.1.
YP_002819454.1. NC_012582.1.

3D structure databases

ProteinModelPortali A5F292.
SMRi A5F292. Positions 6-739.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 345073.VC0395_A0711.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ19957 ; ABQ19957 ; VC0395_A0711 .
ACP09218 ; ACP09218 ; VC395_1208 .
GeneIDi 5137167.
7775156.
KEGGi vco:VC0395_A0711.
vcr:VC395_1208.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Heidelberg J.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395 and O395Imported.
  2. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395 and O395Imported.

Entry informationi

Entry nameiA5F292_VIBC3
AccessioniPrimary (citable) accession number: A5F292
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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