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A5F292

- A5F292_VIBC3

UniProt

A5F292 - A5F292_VIBC3

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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent, monomeric type

Gene

icd

Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei147 – 1471SubstrateUniRule annotation
Sitei257 – 2571Critical for catalysisUniRule annotation
Metal bindingi352 – 3521Magnesium or manganese
Sitei422 – 4221Critical for catalysisUniRule annotation
Binding sitei549 – 5491SubstrateUniRule annotation
Metal bindingi550 – 5501Magnesium or manganese
Metal bindingi554 – 5541Magnesium or manganese

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependent, monomeric typeImported (EC:1.1.1.42Imported)
Submitted name:
NADP-dependent isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
Gene namesi
Name:icdImported
Ordered Locus Names:VC0395_A0711Imported, VC395_1208Imported
OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)Imported
Taxonomic identifieri345073 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000249: Chromosome 2, UP000001630: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi345073.VC0395_A0711.

Structurei

3D structure databases

ProteinModelPortaliA5F292.
SMRiA5F292. Positions 6-739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1418Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

A5F292-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTNKPTIIY TITDEAPALA TYSLLPIIQS FTASSGINVE TRDISLAGRI
60 70 80 90 100
LANFPEHLTE EQRISDALTE LGELAKTPEA NIIKLPNISA SVPQLKAAIK
110 120 130 140 150
ELQDKGYALP NYPEEPSSYE EEAIKATYDK IKGSAVNPVL REGNSDRRAP
160 170 180 190 200
ASVKNYAKKN PHSMGAWSKD SKSHVASMSD KDFFGSEKSM TVSGATKVAI
210 220 230 240 250
EFVGKEGAVK VLKKPFALQD KEIIDTSVMS KKALIAFFEK EIADAKAQDV
260 270 280 290 300
LFSLHMKATM MKVSDPVIFG HAVKVYYKAV FDKYGQLFDQ LGVDVNNGLG
310 320 330 340 350
DVYAKIQSLP EAQRAEIEAA IQAVYATQPA LAMVDSDRGI TNLHVPSDVI
360 370 380 390 400
VDASMPAMIR TSGQMWGPDG KQKDTKATIP DRCYAGVYQT VIDFCKQHGA
410 420 430 440 450
FDPTTMGSVP NVGLMAQKAE EYGSHDKTFI LDAEGVVRVI DEAGKVLLEQ
460 470 480 490 500
SVEAGDIFRM CQVKDAPIQD WVKLAVTRAR ASNTPAVFWL DPARAHDAEL
510 520 530 540 550
IKKVNQYLPN HDTSGLEIKI LSPIEATQYS LVRMKAGQDT ISVTGNVLRD
560 570 580 590 600
YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQVQKENH
610 620 630 640 650
LRWDSLGEFL ALAASLEHLS VVTGNRKAQV LADALDKATG KFLDMNKSPS
660 670 680 690 700
RRVGEIDNRG SHFYLATYWA QALAEQTADA DLAAEFAPIA KALEEKEAQI
710 720 730 740
VAELNGAQGK PGDLGGYYAP EFAKVAPLMR PSSTFNAIID R
Length:741
Mass (Da):80,531
Last modified:June 12, 2007 - v1
Checksum:i9442576499BA54A7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000627 Genomic DNA. Translation: ABQ19957.1.
CP001235 Genomic DNA. Translation: ACP09218.1.
RefSeqiYP_001216661.1. NC_009457.1.
YP_002819454.1. NC_012582.1.

Genome annotation databases

EnsemblBacteriaiABQ19957; ABQ19957; VC0395_A0711.
ACP09218; ACP09218; VC395_1208.
GeneIDi5137167.
7775156.
KEGGivco:VC0395_A0711.
vcr:VC395_1208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000627 Genomic DNA. Translation: ABQ19957.1 .
CP001235 Genomic DNA. Translation: ACP09218.1 .
RefSeqi YP_001216661.1. NC_009457.1.
YP_002819454.1. NC_012582.1.

3D structure databases

ProteinModelPortali A5F292.
SMRi A5F292. Positions 6-739.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 345073.VC0395_A0711.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ19957 ; ABQ19957 ; VC0395_A0711 .
ACP09218 ; ACP09218 ; VC395_1208 .
GeneIDi 5137167.
7775156.
KEGGi vco:VC0395_A0711.
vcr:VC395_1208.

Phylogenomic databases

eggNOGi COG2838.
HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Heidelberg J.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395Imported and O395Imported.
  2. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395 and O395Imported.

Entry informationi

Entry nameiA5F292_VIBC3
AccessioniPrimary (citable) accession number: A5F292
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3