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A5F292

- A5F292_VIBC3

UniProt

A5F292 - A5F292_VIBC3

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent, monomeric type

Gene

icd

Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei147 – 1471SubstrateUniRule annotation
    Sitei257 – 2571Critical for catalysisUniRule annotation
    Metal bindingi352 – 3521Magnesium or manganeseUniRule annotation
    Sitei422 – 4221Critical for catalysisUniRule annotation
    Binding sitei549 – 5491SubstrateUniRule annotation
    Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation
    Metal bindingi554 – 5541Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependent, monomeric typeImported (EC:1.1.1.42Imported)
    Submitted name:
    NADP-dependent isocitrate dehydrogenaseImported (EC:1.1.1.42Imported)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:VC0395_A0711Imported, VC395_1208Imported
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)Imported
    Taxonomic identifieri345073 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000249: Chromosome 2, UP000001630: Chromosome I

    Interactioni

    Protein-protein interaction databases

    STRINGi345073.VC0395_A0711.

    Structurei

    3D structure databases

    ProteinModelPortaliA5F292.
    SMRiA5F292. Positions 6-739.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni134 – 1418Substrate bindingUniRule annotation

    Phylogenomic databases

    eggNOGiCOG2838.
    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiEEQRIGD.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5F292-1 [UniParc]FASTAAdd to Basket

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    MPTNKPTIIY TITDEAPALA TYSLLPIIQS FTASSGINVE TRDISLAGRI    50
    LANFPEHLTE EQRISDALTE LGELAKTPEA NIIKLPNISA SVPQLKAAIK 100
    ELQDKGYALP NYPEEPSSYE EEAIKATYDK IKGSAVNPVL REGNSDRRAP 150
    ASVKNYAKKN PHSMGAWSKD SKSHVASMSD KDFFGSEKSM TVSGATKVAI 200
    EFVGKEGAVK VLKKPFALQD KEIIDTSVMS KKALIAFFEK EIADAKAQDV 250
    LFSLHMKATM MKVSDPVIFG HAVKVYYKAV FDKYGQLFDQ LGVDVNNGLG 300
    DVYAKIQSLP EAQRAEIEAA IQAVYATQPA LAMVDSDRGI TNLHVPSDVI 350
    VDASMPAMIR TSGQMWGPDG KQKDTKATIP DRCYAGVYQT VIDFCKQHGA 400
    FDPTTMGSVP NVGLMAQKAE EYGSHDKTFI LDAEGVVRVI DEAGKVLLEQ 450
    SVEAGDIFRM CQVKDAPIQD WVKLAVTRAR ASNTPAVFWL DPARAHDAEL 500
    IKKVNQYLPN HDTSGLEIKI LSPIEATQYS LVRMKAGQDT ISVTGNVLRD 550
    YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQVQKENH 600
    LRWDSLGEFL ALAASLEHLS VVTGNRKAQV LADALDKATG KFLDMNKSPS 650
    RRVGEIDNRG SHFYLATYWA QALAEQTADA DLAAEFAPIA KALEEKEAQI 700
    VAELNGAQGK PGDLGGYYAP EFAKVAPLMR PSSTFNAIID R 741
    Length:741
    Mass (Da):80,531
    Last modified:June 12, 2007 - v1
    Checksum:i9442576499BA54A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000627 Genomic DNA. Translation: ABQ19957.1.
    CP001235 Genomic DNA. Translation: ACP09218.1.
    RefSeqiYP_001216661.1. NC_009457.1.
    YP_002819454.1. NC_012582.1.

    Genome annotation databases

    EnsemblBacteriaiABQ19957; ABQ19957; VC0395_A0711.
    ACP09218; ACP09218; VC395_1208.
    GeneIDi5137167.
    7775156.
    KEGGivco:VC0395_A0711.
    vcr:VC395_1208.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000627 Genomic DNA. Translation: ABQ19957.1 .
    CP001235 Genomic DNA. Translation: ACP09218.1 .
    RefSeqi YP_001216661.1. NC_009457.1.
    YP_002819454.1. NC_012582.1.

    3D structure databases

    ProteinModelPortali A5F292.
    SMRi A5F292. Positions 6-739.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 345073.VC0395_A0711.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ19957 ; ABQ19957 ; VC0395_A0711 .
    ACP09218 ; ACP09218 ; VC395_1208 .
    GeneIDi 5137167.
    7775156.
    KEGGi vco:VC0395_A0711.
    vcr:VC395_1208.

    Phylogenomic databases

    eggNOGi COG2838.
    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi EEQRIGD.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Heidelberg J.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39541 / Classical Ogawa 395 / O395Imported and O395Imported.
    2. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
      Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
      PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39541 / Classical Ogawa 395 / O395 and O395Imported.

    Entry informationi

    Entry nameiA5F292_VIBC3
    AccessioniPrimary (citable) accession number: A5F292
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 12, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3