A5F292 (A5F292_VIBC3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase, NADP-dependent, monomeric type EMBL ABQ19957.1
EC=1.1.1.42 EMBL ABQ19957.1

Submitted name:
NADP-dependent isocitrate dehydrogenase EMBL ACP09218.1
EC=1.1.1.42 EMBL ACP09218.1

Gene names

Name:	icd EMBL ABQ19957.1
Ordered Locus Names:	VC0395_A0711, VC395_1208

Organism

Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) [Complete proteome] [HAMAP]

Taxonomic identifier

345073 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio cholerae

Protein attributes

Sequence length	741 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Molecular function	Oxidoreductase EMBL ABQ19957.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	134 – 141	8	Substrate binding By similarity
Sites
	Metal binding	352	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	550	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	554	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	147	1	Substrate By similarity
	Binding site	549	1	Substrate By similarity
	Site	257	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	422	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	A5F292 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 9442576499BA54A7	FASTA	741	80,531
	10 20 30 40 50 60 MPTNKPTIIY TITDEAPALA TYSLLPIIQS FTASSGINVE TRDISLAGRI LANFPEHLTE 70 80 90 100 110 120 EQRISDALTE LGELAKTPEA NIIKLPNISA SVPQLKAAIK ELQDKGYALP NYPEEPSSYE 130 140 150 160 170 180 EEAIKATYDK IKGSAVNPVL REGNSDRRAP ASVKNYAKKN PHSMGAWSKD SKSHVASMSD 190 200 210 220 230 240 KDFFGSEKSM TVSGATKVAI EFVGKEGAVK VLKKPFALQD KEIIDTSVMS KKALIAFFEK 250 260 270 280 290 300 EIADAKAQDV LFSLHMKATM MKVSDPVIFG HAVKVYYKAV FDKYGQLFDQ LGVDVNNGLG 310 320 330 340 350 360 DVYAKIQSLP EAQRAEIEAA IQAVYATQPA LAMVDSDRGI TNLHVPSDVI VDASMPAMIR 370 380 390 400 410 420 TSGQMWGPDG KQKDTKATIP DRCYAGVYQT VIDFCKQHGA FDPTTMGSVP NVGLMAQKAE 430 440 450 460 470 480 EYGSHDKTFI LDAEGVVRVI DEAGKVLLEQ SVEAGDIFRM CQVKDAPIQD WVKLAVTRAR 490 500 510 520 530 540 ASNTPAVFWL DPARAHDAEL IKKVNQYLPN HDTSGLEIKI LSPIEATQYS LVRMKAGQDT 550 560 570 580 590 600 ISVTGNVLRD YLTDLFPILE LGTSAKMLSI VPLMNGGGLF ETGAGGSAPK HVQQVQKENH 610 620 630 640 650 660 LRWDSLGEFL ALAASLEHLS VVTGNRKAQV LADALDKATG KFLDMNKSPS RRVGEIDNRG 670 680 690 700 710 720 SHFYLATYWA QALAEQTADA DLAAEFAPIA KALEEKEAQI VAELNGAQGK PGDLGGYYAP 730 740 EFAKVAPLMR PSSTFNAIID R

References

[1]	Heidelberg J. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39541 / Ogawa 395 / O395 [TIGR].
[2]	"A recalibrated molecular clock and independent origins for the cholera pandemic clones." Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L. PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39541 / Ogawa 395 / O395 [Nankai/TEDA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000627 Genomic DNA. Translation: ABQ19957.1. CP001235 Genomic DNA. Translation: ACP09218.1.
RefSeq	YP_001216661.1. NC_009457.1. YP_002819454.1. NC_012582.1.
3D structure databases
SMR	A5F292. Positions 6-739.
ModBase	Search...
Protein-protein interaction databases
STRING	345073.VC0395_A0711.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABQ19957; ABQ19957; VC0395_A0711. ACP09218; ACP09218; VC395_1208.
GeneID	5137167. 7775156.
KEGG	vco:VC0395_A0711. vcr:VC395_1208.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2838.
HOGENOM	HOG000240860.
KO	K00031.
OMA	FRMCQTK.
ProtClustDB	CLSK867411.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5F292_VIBC3

Accession

Primary (citable) accession number: A5F292

Entry history

Integrated into UniProtKB/TrEMBL:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)