A5F1Z2 (A5F1Z2_VIBC3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative phosphoribosylaminoimidazole-succinocarboxamide synthase EMBL ABQ19801.1
EC=6.3.2.6 EMBL ACP09317.1

Gene names

Ordered Locus Names:

VC0395_A0811, VC395_1309

Organism

Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) [Complete proteome] [HAMAP]

Taxonomic identifier

345073 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. SAAS SAAS018236
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. SAAS SAAS018236
Sequence similarities	Belongs to the SAICAR synthetase family. RuleBase RU004193

Ontologies

Keywords
Biological process	Purine biosynthesis SAAS SAAS018236
Ligand	ATP-binding SAAS SAAS018236 Nucleotide-binding
Molecular function	Ligase SAAS SAAS018236 EMBL ACP09317.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5F1Z2 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: FDD730F43A28CD71	FASTA	405	45,799
	10 20 30 40 50 60 MLFVWQHKLV LVSCAQPAVF HSAKSLKRCL NSDRNVSMSL ADQVLAVNDD LPIRTHQPVH 70 80 90 100 110 120 SGKVRSVYWL TEQDSRRLIK EKGYPVAEDA PLAIMVISDR ISAFDCIWHA EGGVHGVPGK 130 140 150 160 170 180 GAALNAISNH WFKLFKQHGL AESHILDIPH PFVWIVQKAR PIKIEAICRQ YITGSMWRAY 190 200 210 220 230 240 AKGEREFCGI TLPEGLEKDS QLPELLMTPS TKGILRGIPG VPEADDVNIS RQDIEANYAA 250 260 270 280 290 300 FNFNQPQDID HYETLLKQGF AVISEALKSV GQLFVDTKFE FGYVADQQGQ QKLIYMDEVG 310 320 330 340 350 360 TPDSSRIWDA QQYQQGKIVE NSKEGFRQFL LNYFPDPDIL LNKDRMPERE ALARDNALPL 370 380 390 400 EALMDISRTY LGIAEKITGQ PIHLSHQPKQ EIIAILDKEY GLIER

References

[1]	"A recalibrated molecular clock and independent origins for the cholera pandemic clones." Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L. PLoS ONE 3:E4053-E4053(2008) [PubMed: 19115014] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39541 / Ogawa 395 / O395 [Nankai/TEDA].
[2]	Heidelberg J. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39541 / Ogawa 395 / O395 [TIGR].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000627 Genomic DNA. Translation: ABQ19801.1. CP001235 Genomic DNA. Translation: ACP09317.1.
3D structure databases
ProteinModelPortal	A5F1Z2.
ModBase	Search...
Protein-protein interaction databases
STRING	A5F1Z2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GenomeReviews	Gene locus VC0395_A0811 in contig CP000627_GR. Gene locus VC395_1309 in contig CP001235_GR.
KEGG	vco:VC0395_A0811.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0152.
HOGENOM	HBG555040.
OMA	SSRIWDG.
ProtClustDB	PRK13960.
Enzyme and pathway databases
BioCyc	VCHO345073:VC0395_A0811-MONOMER.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR014106. PurC_vibrio. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR02735. PurC_vibrio. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5F1Z2_VIBC3

Accession

Primary (citable) accession number: A5F1Z2

Entry history

Integrated into UniProtKB/TrEMBL:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)