A5F1F1 (PNCB_VIBC3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	VC0395_0041, VC395_A0091

Organism

Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) [Complete proteome] [HAMAP]

Taxonomic identifier

345073 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio cholerae

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 435	435	Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570		PRO_1000072576

Sequences

	Sequence		Length	Mass (Da)
	A5F1F1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 2CEF5D950C6C11FE	FASTA	435	50,078
	10 20 30 40 50 60 MNPRLFSPHI IRSLLDLDAY KINMMQAIHH FYPDVSVRYE LIVRSEEDAS GLLDAIRQEI 70 80 90 100 110 120 AHLGTLRFSD ADIHYLTQHA PHLKATFLQS LRYFHFVPQE QVEMGIVKQG GKQQLRISIR 130 140 150 160 170 180 GSWRDTILYE TLVMAIVSEV RSRQRWAEVP ADLPLKVLKT KLDQLKAEIE RRGINNFSLT 190 200 210 220 230 240 EMGTRRRFSS QVQRDVLACL KQEIPQWVLG TSNYHFAREF DLKPIGTIAH EWFMGHQALV 250 260 270 280 290 300 NERDSQQVAL ERWLTAFDGM LAIAPTDTLT IDAFLNDFNR HLANAYDGVR HDSGCPFRWG 310 320 330 340 350 360 DKMIAHYQQL GIDPTTKLFI FSDGLDFDQA LELCEYFAGR VKISFGIGTF LTNDLANWRN 370 380 390 400 410 420 AAGVEYRPLS IVIKLAECQG RPVAKISDQP EKAMCEDPIF LANLKRRFNI ELDVDALIQE 430 LRHQKRSPRH YISAA

References

[1]	Heidelberg J. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39541 / Ogawa 395 / O395.
[2]	"A recalibrated molecular clock and independent origins for the cholera pandemic clones." Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L. PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39541 / Ogawa 395 / O395.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000626 Genomic DNA. Translation: ABQ19254.1. CP001236 Genomic DNA. Translation: ACP10938.1.
RefSeq	YP_001214882.1. NC_009456.1. YP_002821174.1. NC_012583.1.
3D structure databases
ProteinModelPortal	A5F1F1.
ModBase	Search...
Protein-protein interaction databases
STRING	345073.VC0395_0041.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABQ19254; ABQ19254; VC0395_0041. ACP10938; ACP10938; VC395_A0091.
GeneID	5134178. 7777168.
KEGG	vco:VC0395_0041. vcr:VC395_A0091.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1488.
HOGENOM	HOG000284928.
KO	K00763.
OMA	SFGWGTN.
ProtClustDB	PRK05321.
Enzyme and pathway databases
UniPathway	UPA00253; UER00457.
Family and domain databases
HAMAP	MF_00570. NAPRTase.
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
PANTHER	PTHR11098:SF1. PTHR11098:SF1. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_VIBC3

Accession

Primary (citable) accession number: A5F1F1
Secondary accession number(s): C3M7E2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program