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A5F0H0

- A5F0H0_VIBC3

UniProt

A5F0H0 - A5F0H0_VIBC3

Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

    Catalytic activityi

    L-arginine = agmatine + CO2.UniRule annotationSAAS annotation

    Cofactori

    Magnesium.UniRule annotationSAAS annotation
    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine catabolic process Source: InterPro
    2. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotationSAAS annotation, Lyase

    Keywords - Biological processi

    Polyamine biosynthesisUniRule annotation, Spermidine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    UniPathwayiUPA00186; UER00284.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
    Short name:
    ADCUniRule annotation
    Gene namesi
    Name:speAUniRule annotationImported
    Ordered Locus Names:VC0395_0419Imported, VC395_A0839Imported
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)Imported
    Taxonomic identifieri345073 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000001630: Chromosome II, UP000000249: Chromosome 1

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei126 – 1261N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi345073.VC0395_0419.

    Structurei

    3D structure databases

    ProteinModelPortaliA5F0H0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni311 – 32111Substrate-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1166.
    HOGENOMiHOG000029191.
    KOiK01585.
    OMAiIDHYVDG.

    Family and domain databases

    Gene3Di2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPiMF_01417. SpeA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022644. De-COase2_N.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSiPR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMiSSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01273. speA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5F0H0-1 [UniParc]FASTAAdd to Basket

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    MTSRVSGVIS TDEIIVILSV FVRYDVEQPS KLDRVRADYN VHYWSQGFFG    50
    IDDQGEVYVS PRKDKAHQTQ LSSIVKQLEA RDLNLPVLVR FPQILHQRVH 100
    NICDAFNQAI EEYDYPNKYL LVYPIKVNQQ KEVVDEILAS QAELEHKQLG 150
    LEAGSKPELL AVLAMAQQAS SVIVCNGYKD REYIRLALIG EKLGHKVFIV 200
    LEKLSELDLV LKEAKSLGVK PRLGLRIRLA SQGAGKWQSS GGEKSKFGLA 250
    ASQVLTVINR LKAENQLEAL QLVHFHLGSQ MANIRDVRNG VNEAVRFYCE 300
    LRELGAHIDF FDVGGGLAVD YDGTRSQSSN SMNYGLHEYA RNIVSTVSDV 350
    CNLYGQPRPV IISESGRSIT AHHAVLITNV IGTEAYSPEE IPAPGADAPM 400
    LLKNMWRGFE EVQHGTDDRA LIEIYNDTQS DLSEAHSQFA TGVLNLEHRA 450
    WAEQLSLRIY HELRQKMSNK NRFHRPILDE LQERLADKFF VNFSLFQSLP 500
    DAWGIDQVFP VLPLSGLEEM NDRRAVMLDI TCDSDGAVEQ YVEGQGIEST 550
    LPVPAWTSDK PYLMGFFLVG AYQEILGDMH NLFGDTHSAV VNINDNGESE 600
    IAFINEGDTV EDMMRYVHID VDKIRTNYRQ LVSQRVAKEE QETVLAELEL 650
    GLSGYTYLED F 661
    Length:661
    Mass (Da):74,465
    Last modified:June 12, 2007 - v1
    Checksum:i44F4E37A2D81AC43
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000626 Genomic DNA. Translation: ABQ19043.1.
    CP001236 Genomic DNA. Translation: ACP11672.1.
    RefSeqiYP_001215260.1. NC_009456.1.
    YP_002821908.1. NC_012583.1.

    Genome annotation databases

    EnsemblBacteriaiABQ19043; ABQ19043; VC0395_0419.
    ACP11672; ACP11672; VC395_A0839.
    GeneIDi5134840.
    7777902.
    KEGGivco:VC0395_0419.
    vcr:VC395_A0839.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000626 Genomic DNA. Translation: ABQ19043.1 .
    CP001236 Genomic DNA. Translation: ACP11672.1 .
    RefSeqi YP_001215260.1. NC_009456.1.
    YP_002821908.1. NC_012583.1.

    3D structure databases

    ProteinModelPortali A5F0H0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 345073.VC0395_0419.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ19043 ; ABQ19043 ; VC0395_0419 .
    ACP11672 ; ACP11672 ; VC395_A0839 .
    GeneIDi 5134840.
    7777902.
    KEGGi vco:VC0395_0419.
    vcr:VC395_A0839.

    Phylogenomic databases

    eggNOGi COG1166.
    HOGENOMi HOG000029191.
    KOi K01585.
    OMAi IDHYVDG.

    Enzyme and pathway databases

    UniPathwayi UPA00186 ; UER00284 .

    Family and domain databases

    Gene3Di 2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPi MF_01417. SpeA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022644. De-COase2_N.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSi PR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMi SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01273. speA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Heidelberg J.
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39541 / Classical Ogawa 395 / O395 and O395Imported.
    2. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
      Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
      PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39541 / Classical Ogawa 395 / O395Imported and O395Imported.

    Entry informationi

    Entry nameiA5F0H0_VIBC3
    AccessioniPrimary (citable) accession number: A5F0H0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 12, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3