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A5EYY8

- GCSP_VIBC3

UniProt

A5EYY8 - GCSP_VIBC3

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, VC0395_0955, VC395_A0313
Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:VC0395_0955, VC395_A0313
OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Taxonomic identifieri345073 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000249: Chromosome 1, UP000001630: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000072766Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi345073.VC0395_0955.

Structurei

3D structure databases

ProteinModelPortaliA5EYY8.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiTAYLTHP.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A5EYY8-1 [UniParc]FASTAAdd to Basket

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MTELLHSLST QNEFVARHNG PDKQEQATML KTVNAESLDA LIAQTVPAQI    50
RLEAPMQLAP AQSEADMLAT MKSFAKLNQL KRTFIGQGYY NTFTPNVILR 100
NVMENPGWYT AYTPYQPEIS QGRLESLLNY QQMVMDLTAM EIANASLLDE 150
ATAAAEAMAL CQRAGKSKSN LFFVADDVHP QTIEVVKTRA AFLGFEVKVD 200
SIDNITQQEA FGALLQYPGT TGEVRDLTDI IAKAQANKTL VTVATDLLAS 250
VLLKPAGEMG ADVVIGSAQR FGVPMGYGGP HAAFMATRDA HKRTMPGRVI 300
GVSIDAKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMAAFYAVYH 350
GPQGLRTIAR RAHHLTAILA AGLTKAGYEL AHQHFFDTLA INTGAKTDAL 400
YQAAQQANIN LRKLPNQLGV SFDETTTVAD VEALFAIFGI KEEVHALSDR 450
IATNELAAIP ESCRRQSAFL THPVFNTHHS ETQMLRYMKH LENKDFSLTH 500
GMIPLGSCTM KLNATAEMIP VTWPEFGALH PFVPKAQAAG YAALAEDLKQ 550
KLCEITGYDA FSLQPNSGAS GEYAGLVAIQ RYHQSRGEGH RNVCLIPSSA 600
HGTNPATAAM VSMKVVVVKC DENGNIDMVD LADKIEKHKD HLSSIMITYP 650
STHGVYEQQV REVCEMVHAA GGQVYLDGAN MNAQVGLTSP GFIGSDVSHL 700
NLHKTFCIPH GGGGPGMGPI GVKSHLAPFL PGHIEGGVEG SDFAVSAADL 750
GSASILPISW AYIAMMGADG LAEATKLAIL NANYVMERLR PHYPILYRGA 800
NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM SFPVAGTLMV 850
EPTESEDLAE LDRFCDALIA IRGEIDKVKN GEWPLESNPL VHAPHTQADL 900
REEKWDRPYS REIACFPSAH TKASKYWPTV NRVDNVYGDR NLVCSCPSID 950
SYQD 954
Length:954
Mass (Da):103,954
Last modified:June 12, 2007 - v1
Checksum:iB2336F8CE80C806A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000626 Genomic DNA. Translation: ABQ18474.1.
CP001236 Genomic DNA. Translation: ACP11153.1.
RefSeqiYP_001215791.1. NC_009456.1.
YP_002821389.1. NC_012583.1.

Genome annotation databases

EnsemblBacteriaiABQ18474; ABQ18474; VC0395_0955.
ACP11153; ACP11153; VC395_A0313.
GeneIDi5134471.
7777383.
KEGGivco:VC0395_0955.
vcr:VC395_A0313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000626 Genomic DNA. Translation: ABQ18474.1 .
CP001236 Genomic DNA. Translation: ACP11153.1 .
RefSeqi YP_001215791.1. NC_009456.1.
YP_002821389.1. NC_012583.1.

3D structure databases

ProteinModelPortali A5EYY8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 345073.VC0395_0955.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ18474 ; ABQ18474 ; VC0395_0955 .
ACP11153 ; ACP11153 ; VC395_A0313 .
GeneIDi 5134471.
7777383.
KEGGi vco:VC0395_0955.
vcr:VC395_A0313.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi TAYLTHP.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Heidelberg J.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395.
  2. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395.

Entry informationi

Entry nameiGCSP_VIBC3
AccessioniPrimary (citable) accession number: A5EYY8
Secondary accession number(s): C3M807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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