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Protein

Alpha-amylase

Gene

amy1

Organism
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.UniRule annotation

GO - Molecular functioni

  1. alpha-amylase activity Source: UniProtKB-EC
  2. cation binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationImported, Hydrolase

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-amylaseUniRule annotation (EC:3.2.1.1UniRule annotation)
Gene namesi
Name:amy1Imported
Ordered Locus Names:VC0395_0979Imported, VC395_A0287Imported
OrganismiVibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)Imported
Taxonomic identifieri345073 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000249: Chromosome 1, UP000001630: Chromosome II

Interactioni

Protein-protein interaction databases

STRINGi345073.VC0395_0979.

Structurei

3D structure databases

ProteinModelPortaliA5EYX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0366.
HOGENOMiHOG000274290.
KOiK01176.
OMAiDLDPNNW.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR006046. Alpha_amylase.
IPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
PRINTSiPR00110. ALPHAAMYLASE.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

A5EYX2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MKSSYVVLCA TFAAASFTSS VQAEAILHAF NWKYADVTAN AAQIAAAGYK
60 70 80 90 100
KVLISPALKS SGNEWWARYQ PQDLRVIDSP LGNKTDLQTL IKTLQDYGVE
110 120 130 140 150
VYSDVVFNHM ANESWKRSDL NYPGSEVLAS YTNQAYYYQQ QKLFGDLSHN
160 170 180 190 200
LFSQNDFHPE GCITDWGNPG HVQYWRLCGG AGDRGLPDLD ANAWVINQQR
210 220 230 240 250
AYLQALKQMG IRGFRIDAVK HMSQYHIDQV FTPEIISGMH VFGEVITSGG
260 270 280 290 300
QGDGSYDAFL APYLNNTTHA AYDFPLFASI RAAFSYQGSM SQLHDPQAYG
310 320 330 340 350
QALPNARAIT FAITHDIPTN DGFRYQILNP QDEQLAYAYL LGKDGGTPLI
360 370 380 390 400
YSDDLADHED KDNGRWANVW NQPSMQHMLR FHNAMQGKPM TVMYSDSCLL
410 420 430 440 450
LFKRGKEGVV GINKCGESKN VTIDTYQHEF NWYQTYQDTL SDDRFSVSSR
460
YHTLTIPARV ARMWML
Length:466
Mass (Da):52,555
Last modified:June 12, 2007 - v1
Checksum:i7CABB6C280C1EC8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000626 Genomic DNA. Translation: ABQ18339.1.
CP001236 Genomic DNA. Translation: ACP11128.1.
RefSeqiYP_001215815.1. NC_009456.1.
YP_002821364.1. NC_012583.1.

Genome annotation databases

EnsemblBacteriaiABQ18339; ABQ18339; VC0395_0979.
ACP11128; ACP11128; VC395_A0287.
GeneIDi5135031.
7777358.
KEGGivco:VC0395_0979.
vcr:VC395_A0287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000626 Genomic DNA. Translation: ABQ18339.1.
CP001236 Genomic DNA. Translation: ACP11128.1.
RefSeqiYP_001215815.1. NC_009456.1.
YP_002821364.1. NC_012583.1.

3D structure databases

ProteinModelPortaliA5EYX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi345073.VC0395_0979.

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ18339; ABQ18339; VC0395_0979.
ACP11128; ACP11128; VC395_A0287.
GeneIDi5135031.
7777358.
KEGGivco:VC0395_0979.
vcr:VC395_A0287.

Phylogenomic databases

eggNOGiCOG0366.
HOGENOMiHOG000274290.
KOiK01176.
OMAiDLDPNNW.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR006046. Alpha_amylase.
IPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
PRINTSiPR00110. ALPHAAMYLASE.
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Heidelberg J.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395 and O395Imported.
  2. "A recalibrated molecular clock and independent origins for the cholera pandemic clones."
    Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
    PLoS ONE 3:E4053-E4053(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39541 / Classical Ogawa 395 / O395Imported and O395Imported.

Entry informationi

Entry nameiA5EYX2_VIBC3
AccessioniPrimary (citable) accession number: A5EYX2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: January 7, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.