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A5EYH1 (A5EYH1_VIBC3) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptide deformylase 1 HAMAP MF_00163
Short name=PDF 1 HAMAP MF_00163
EC=3.5.1.88 HAMAP MF_00163
Alternative name(s):
Polypeptide deformylase 1 HAMAP MF_00163
Gene names
Name:def-2 EMBL ABQ18961.1
Synonyms:def1 HAMAP MF_00163
Ordered Locus Names:VC0395_1128, VC395_A0143
OrganismVibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) [Complete proteome] [HAMAP]
Taxonomic identifier345073 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length168 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP MF_00163

Catalytic activity

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. SAAS SAAS000181 HAMAP MF_00163

Cofactor

Binds 1 Fe2+ ion By similarity. HAMAP MF_00163

Sequence similarities

Belongs to the polypeptide deformylase family. RuleBase RU003335 HAMAP MF_00163

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1341 By similarity HAMAP MF_00163
Metal binding911Iron By similarity HAMAP MF_00163
Metal binding1331Iron By similarity HAMAP MF_00163
Metal binding1371Iron By similarity HAMAP MF_00163

Sequences

Sequence LengthMass (Da)Tools
A5EYH1 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: F51EDDE3B6C14C59

FASTA16818,671
        10         20         30         40         50         60 
MAVLEILTAP DPRLRVQSKQ VTDVASVQTL IDDLLDTLYA TDNGIGLAAP QVGREEAIVV 

        70         80         90        100        110        120 
IDLSDNRDQP LVLINPKVVS GSNKEMGQEG CLSVPDYYAD VERYTSVVVE ALDREGKPLR 

       130        140        150        160 
IETSDFLAIV MQHEIDHLSG NLFIDYLSPL KQQMAMKKVK KHVKNRAR

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References

[1]"A recalibrated molecular clock and independent origins for the cholera pandemic clones."
Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J., Wang W., Wang J., Qian W., Li D., Wang L.
PLoS ONE 3:E4053-E4053(2008) [PubMed: 19115014] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39541 / Ogawa 395 / O395 [Nankai/TEDA].
[2]Heidelberg J.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39541 / Ogawa 395 / O395 [TIGR].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000626 Genomic DNA. Translation: ABQ18961.1.
CP001236 Genomic DNA. Translation: ACP10986.1.

3D structure databases

ProteinModelPortalA5EYH1.
SMRA5EYH1. Positions 2-168.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5EYH1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GenomeReviewsGene locus VC0395_1128 in contig CP000626_GR.
Gene locus VC395_A0143 in contig CP001236_GR.
KEGGvco:VC0395_1128.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0242.
HOGENOMHBG665227.
OMAMINAHIE.
ProtClustDBPRK12846.

Enzyme and pathway databases

BioCycVCHO345073:VC0395_1128-MONOMER.

Family and domain databases

HAMAPMF_00163. Pep_deformylase.
[Tree]
InterProIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
Gene3DG3DSA:3.90.45.10. Fmet_deformylase. 1 hit.
KOK01462.
PANTHERPTHR10458. Fmet_deformylase. 1 hit.
PfamPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFPIRSF004749. Pep_def. 1 hit.
PRINTSPR01576. PDEFORMYLASE.
SUPFAMSSF56420. Fmet_deformylase. 1 hit.
TIGRFAMsTIGR00079. Pept_deformyl. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA5EYH1_VIBC3
AccessionPrimary (citable) accession number: A5EYH1
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: November 16, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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