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A5EY60

- THIM_DICNV

UniProt

A5EY60 - THIM_DICNV

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Protein
Hydroxyethylthiazole kinase
Gene
thiM, DNO_0932
Organism
Dichelobacter nodosus (strain VCS1703A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621Substrate; via amide nitrogen By similarity
Binding sitei138 – 1381ATP By similarity
Binding sitei183 – 1831ATP By similarity
Binding sitei210 – 2101Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDNOD246195:GHHS-929-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:DNO_0932
OrganismiDichelobacter nodosus (strain VCS1703A)
Taxonomic identifieri246195 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCardiobacterialesCardiobacteriaceaeDichelobacter
ProteomesiUP000000248: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Hydroxyethylthiazole kinaseUniRule annotation
PRO_0000383857Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi246195.DNO_0932.

Structurei

3D structure databases

ProteinModelPortaliA5EY60.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiQTFTANV.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

A5EY60-1 [UniParc]FASTAAdd to Basket

« Hide

MTESLEMGKS IDFNVQTFDF KSAQFYLDRA YANAPFIHCL TNNTTKFFVA    50
NALLAIGAKP AMVESWQEVV EFSQRAANVV MNLDSLTDER LRSLSMSAQV 100
AHDHGKWWVF DPAAVSDILS YRSGFARELL RYYPRVIRGN ASEISYLNDT 150
YGRRSFENVM SSSEAIEAAV KLAIHQRAVV VVTGEIDYVT DGETILAVRG 200
GHPFLGRVCG TGCVLSAMIA STVLCGDVLY GAASACALMK RAGERAGLTT 250
SGLGSFYVAL LDNLTFPMRY QD 272
Length:272
Mass (Da):29,851
Last modified:June 12, 2007 - v1
Checksum:i3F4649CB6ACBA9F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000513 Genomic DNA. Translation: ABQ13771.1.
RefSeqiWP_012031248.1. NC_009446.1.
YP_001209824.1. NC_009446.1.

Genome annotation databases

EnsemblBacteriaiABQ13771; ABQ13771; DNO_0932.
GeneIDi5122270.
KEGGidno:DNO_0932.
PATRICi21786200. VBIDicNod48475_0931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000513 Genomic DNA. Translation: ABQ13771.1 .
RefSeqi WP_012031248.1. NC_009446.1.
YP_001209824.1. NC_009446.1.

3D structure databases

ProteinModelPortali A5EY60.
ModBasei Search...

Protein-protein interaction databases

STRINGi 246195.DNO_0932.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ13771 ; ABQ13771 ; DNO_0932 .
GeneIDi 5122270.
KEGGi dno:DNO_0932.
PATRICi 21786200. VBIDicNod48475_0931.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi QTFTANV.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci DNOD246195:GHHS-929-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VCS1703A.

Entry informationi

Entry nameiTHIM_DICNV
AccessioniPrimary (citable) accession number: A5EY60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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