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A5EXU4 (SYR_DICNV) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:DNO_1051
OrganismDichelobacter nodosus (strain VCS1703A) [Complete proteome] [HAMAP]
Taxonomic identifier246195 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaCardiobacterialesCardiobacteriaceaeDichelobacter

Protein attributes

Sequence length592 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 592592Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000018022

Regions

Motif129 – 13911"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
A5EXU4 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 3FE8F435BF720C72

FASTA59267,382
        10         20         30         40         50         60 
MKNEIQDGLG SALILVAKNH GIDIRLLDQA IEIERCKDPE NGDFASNIAL KYAKVFKMKP 

        70         80         90        100        110        120 
RQLADELVVS VPLMDSVAGM EVAGPGFINI RLSRESITAV LENVVAKKER YGCFENPNAR 

       130        140        150        160        170        180 
KILVEFVSAN PTGPLHVGHG RGAAYGDSLS RLLIANGHQV DREYYINDFG RQMDILALSV 

       190        200        210        220        230        240 
YWRYVQECGI GVALPKGIYQ GDYVIDIAKK LKEKEGKRLA YPVNEWAPDY PQTWTQEQVD 

       250        260        270        280        290        300 
NGDRDRWIDG AIAGLKEKLG QKEYRGVFDL ALSMELDDIR GDLEEFGVFF DRWFSERSMS 

       310        320        330        340        350        360 
ENDMINNALK KVDEAGYLYE KDGAVWFKST AFGDEKDRVV RRKNGMTTYF SSDISYHFDK 

       370        380        390        400        410        420 
YNRGYDQMID ILGADHHGYM ARVRASLAAL GLDPEKLVIA LVQFAVLYKG GEKMQMSTRS 

       430        440        450        460        470        480 
GEFVTLRDLR EHVGADAARF FYVMRKPEQH LDFDLDLAES NSKDNPFYYV EYAHARCCGM 

       490        500        510        520        530        540 
LNKAEEEGYE FSPEAALKCR NALVEPEETA LISELHRYPE VVIAAGKQMA PHQVIIYLKE 

       550        560        570        580        590 
LATRWHHYYD VGHKVLHEDE EIRNARLLLT WAVRQVLRNA LAIIGVQARE RM 

« Hide

References

[1]"Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus."
Myers G.S.A., Parker D., Al-Hasani K., Kennan R.M., Seemann T., Ren Q., Badger J.H., Selengut J.D., Deboy R.T., Tettelin H., Boyce J.D., McCarl V.P., Han X., Nelson W.C., Madupu R., Mohamoud Y., Holley T., Fedorova N. expand/collapse author list , Khouri H., Bottomley S.P., Whittington R.J., Adler B., Songer J.G., Rood J.I., Paulsen I.T.
Nat. Biotechnol. 25:569-575(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VCS1703A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000513 Genomic DNA. Translation: ABQ14047.1.
RefSeqYP_001209938.1. NC_009446.1.

3D structure databases

ProteinModelPortalA5EXU4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING246195.DNO_1051.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ14047; ABQ14047; DNO_1051.
GeneID5123417.
KEGGdno:DNO_1051.
PATRIC21786440. VBIDicNod48475_1047.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMAMEHMGFG.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycDNOD246195:GHHS-1048-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_DICNV
AccessionPrimary (citable) accession number: A5EXU4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries