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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Dichelobacter nodosus (strain VCS1703A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi486MagnesiumUniRule annotation1
Metal bindingi492MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciDNOD246195:G1G7U-1045-MONOMER
BRENDAi2.7.7.8 11943

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:DNO_1047
OrganismiDichelobacter nodosus (strain VCS1703A)
Taxonomic identifieri246195 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCardiobacterialesCardiobacteriaceaeDichelobacter
Proteomesi
  • UP000000248 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003296281 – 693Polyribonucleotide nucleotidyltransferaseAdd BLAST693

Proteomic databases

PRIDEiA5EXU0

Interactioni

Subunit structurei

Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.UniRule annotation

Protein-protein interaction databases

STRINGi246195.DNO_1047

Structurei

3D structure databases

ProteinModelPortaliA5EXU0
SMRiA5EXU0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini553 – 612KHUniRule annotationAdd BLAST60
Domaini622 – 690S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218327
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

A5EXU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHSVSFTYG QHQVTLETGE IARQADGAVI VNMDDTIVLV TVVANKTVAE
60 70 80 90 100
GQDFFPLTVD YQEKNYAAGK IPGGFFKREG RPSEEETLIS RLIDRPIRPL
110 120 130 140 150
FADGFLNEVQ IIATVLSYNP EVSPDIPSII GASAALKLSG LPFNGPIAAA
160 170 180 190 200
RVGYVNDAYV LNPSPKALKN SRLDLVVAGT ESAVLMVESE ADQLSEAVML
210 220 230 240 250
EAVMFGHRQQ QVVIKSINEL AAQAAKPAWA WQSPARDEQL DTEVKNHFEE
260 270 280 290 300
RLVAAYQIAH KQTRQETVAQ IHADAVALLG IQNNAHGWEE TLVNEYVHHL
310 320 330 340 350
AYRIVRDRIL KKQPRIDGRD TKTVRPITIH TSVLPRAHGS ALFTRGETQA
360 370 380 390 400
LVVATLGTGR DAQLLDTLDG EVRDNFMLHY NFLPFSVGEI GRIGSPKRRE
410 420 430 440 450
IGHGRLARRG LSAVLPLEED FPYTIRVVSE ITESNGSSSM ASVCGSSLAL
460 470 480 490 500
MDAGVPVQTP VAGIAMGLIK EGDEFAILTD ILGDEDHLGD MDFKVAGSAT
510 520 530 540 550
GVTALQMDIK INGITEEIMR QALSQAHEGR LHILEVMNQA IAAPRAELSD
560 570 580 590 600
YAPRFSSMRI DTEKIKDVIG KGGATIRSIT EQTGTTIEIE DDGSVKIAAT
610 620 630 640 650
DKAAAANARR LIEEIVAEPE IGRIYDAKVT KITDFGAFLQ FLPGKEGLVH
660 670 680 690
ISQIADYRVN DVRDELTEGQ EVKVKLLEID RQGRVRLSIK EAK
Length:693
Mass (Da):75,726
Last modified:June 12, 2007 - v1
Checksum:i55CCDBF1C993DF2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000513 Genomic DNA Translation: ABQ14284.1
RefSeqiWP_012031354.1, NC_009446.1

Genome annotation databases

EnsemblBacteriaiABQ14284; ABQ14284; DNO_1047
KEGGidno:DNO_1047

Similar proteinsi

Entry informationi

Entry nameiPNP_DICNV
AccessioniPrimary (citable) accession number: A5EXU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health